A7I2W9 (ARGC_CAMHC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	CHAB381_1309

Organism

Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A) [Complete proteome] [HAMAP]

Taxonomic identifier

360107 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm By similarity HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000096717
Sites
	Active site	147	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7I2W9 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 218C9B048E123FAD	FASTA	335	36,898
	10 20 30 40 50 60 MKKIGIIGVS GYTGLELIKI ILNHSGFKLS YLAATSEGEI SEIFPQLAGV LNMKVEIADA 70 80 90 100 110 120 KEAAKRCDLV FLALPHEKAM EFAREILEFN STKVVDLSAD YRLSLKLYEK NYTKHLDPKN 130 140 150 160 170 180 LSHAVYGLVE INREKIKKAR LVANPGCYPT CSILAIAPFV NFIDKNIGVF IDAKSGVSGA 190 200 210 220 230 240 GKGLKTTSHF VSANENLNAY SPITHRHADE IKEQIGILAG SEIDTIFVPN LVSITRGMSV 250 260 270 280 290 300 SVFAVLKEKI DADKILKEFY KDEEFIRFRD EPVQIKNVVG THFCDIFVRT ACNKIFINSA 310 320 330 IDNLLKGASS QAVANANLML DEPENSALPK IAYGI

References

[1]

"Complete genome sequence of Campylobacter hominis ATCC BAA-381, a commensal isolated from the human gastrointestinal tract." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Nelson K.E. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000776 Genomic DNA. Translation: ABS51316.1.
RefSeq	YP_001406860.1. NC_009714.1.
3D structure databases
ProteinModelPortal	A7I2W9.
ModBase	Search...
Protein-protein interaction databases
STRING	A7I2W9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5409227.
GenomeReviews	Gene locus CHAB381_1309 in contig CP000776_GR.
KEGG	cha:CHAB381_1309.
NMPDR	fig|360107.5.peg.1290.
PATRIC	20040736. VBICamHom81367_1262.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0002.
HOGENOM	HBG294213.
OMA	TAEDCTT.
ProtClustDB	PRK00436.
Enzyme and pathway databases
BioCyc	CHOM360107:CHAB381_1309-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_CAMHC

Accession

Primary (citable) accession number: A7I2W9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	September 11, 2007
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program