A7I2V8 (HIS8_CAMHC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histidinol-phosphate aminotransferase
EC=2.6.1.9

Alternative name(s):
Imidazole acetol-phosphate transaminase

Gene names

Name:	hisC
Ordered Locus Names:	CHAB381_1298

Organism

Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A) [Complete proteome] [HAMAP]

Taxonomic identifier

360107 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Histidinol-phosphate aminotransferase HAMAP MF_01023		PRO_1000063466
Amino acid modifications
	Modified residue	227	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7I2V8 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 63DB6E91F86A29FD	FASTA	366	40,985
	10 20 30 40 50 60 MKFNDYVENL QNYEAGKPVE LVVREYGVKE DDVIKLASNE NPLGTGKKAV KAIYKMAKHA 70 80 90 100 110 120 NLYPDDSMFE LKGALADKYG VSEKNVIIGA GSDQIIEFLI HAKCNENNGI LTAGTTFSMY 130 140 150 160 170 180 GIYAKHAKAK HFSTASKFHD LKEIKELYES HKDEISVIFL CVPNNPLGEC LDAKDVIKFI 190 200 210 220 230 240 KSIDDDTLVV IDAAYNEFAS FKDKHKHIEP AEIVKLKNAI YLGTFSKVYG LGGLRVGYGV 250 260 270 280 290 300 ADEKIISALY KLRPPFNVAN LSLAAAVAAL QDKKFIEKTI KNNFKEMKKY EKFANATGIK 310 320 330 340 350 360 FIKSYTNFIT FILDESKKSS EISQKLLEKG LIVRDLKGYG LNAIRITVGL PKQNKRIFDE LRKLLG

References

[1]

"Complete genome sequence of Campylobacter hominis ATCC BAA-381, a commensal isolated from the human gastrointestinal tract." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Nelson K.E. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000776 Genomic DNA. Translation: ABS52297.1.
RefSeq	YP_001406849.1. NC_009714.1.
3D structure databases
ProteinModelPortal	A7I2V8.
ModBase	Search...
Protein-protein interaction databases
STRING	A7I2V8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5408457.
GenomeReviews	Gene locus CHAB381_1298 in contig CP000776_GR.
KEGG	cha:CHAB381_1298.
NMPDR	fig|360107.5.peg.1279.
PATRIC	20040714. VBICamHom81367_1251.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0079.
HOGENOM	HBG646350.
OMA	YEYAEAE.
ProtClustDB	PRK02731.
Enzyme and pathway databases
BioCyc	CHOM360107:CHAB381_1298-MONOMER.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00817.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01141. HisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS8_CAMHC

Accession

Primary (citable) accession number: A7I2V8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	September 11, 2007
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program