Reviewed, UniProtKB/Swiss-Prot A7I291 (AROB_CAMHC)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	CHAB381_1074

Organism

Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A) [Complete proteome] [HAMAP]

Taxonomic identifier

360107 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. NAD By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	3-dehydroquinate synthase HAMAP MF_00110		PRO_1000117478

Sequences

	Sequence		Length	Mass (Da)
	A7I291-1 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 9B39A682E8864C79	FASTA	344	38,649
	10 20 30 40 50 60 MQVNVDLKEN SYKVFIDEFK ELTIKGNVAI ITNPKVGGLW LEFLLKNLKC DKKFIISVPD 70 80 90 100 110 120 GEEYKNLNTI EQILEQLFSS KCDRKTTLIA LGGGVISDMT GFAASIFERG IDFINFPTTL 130 140 150 160 170 180 LAQVDASVGG KTGVNNKFGK NLIGSFHQPK AVFCESEFLN TLPPREFSAG VAEAIKMAVM 190 200 210 220 230 240 FDKKFFEFFE NSTLKSSDEI AKMVQTCVKI KADVVVKDEK ETGIRAVLNY GHTFAHVIER 250 260 270 280 290 300 ITDYKEFLHG EAVSIGINMA NNLALRLGFL SKNEVFKISE TLKKFNLPTT FKIPNADEFY 310 320 330 340 ELFFMDKKTQ NSKIKFILAN SIGEFKICTD IPKDVVIATL KDFE

References

[1]

"Complete genome sequence of Campylobacter hominis ATCC BAA-381, a commensal isolated from the human gastrointestinal tract." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Nelson K.E. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000776 Genomic DNA. Translation: ABS51355.1.
RefSeq	YP_001406632.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A7I291.
Genome annotation databases
GeneID	5409425.
GenomeReviews	Gene locus CHAB381_1074 in contig CP000776_GR.
KEGG	cha:CHAB381_1074.
NMPDR	fig|360107.5.peg.1057.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EDYLPHM.
Family and domain databases
HAMAP	MF_00110. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_CAMHC

Accession

Primary (citable) accession number: A7I291

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 11, 2007
Last modified:	November 3, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)