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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei144GTPUniRule annotation1
Binding sitei148GTPUniRule annotation1
Binding sitei193GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 28GTPUniRule annotation5
Nucleotide bindingi113 – 115GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, SeptationUniRule annotation
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotationImported
Ordered Locus Names:CHAB381_0822Imported
OrganismiCampylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A)Imported
Taxonomic identifieri360107 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000002407 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi360107.CHAB381_0822.

Structurei

3D structure databases

ProteinModelPortaliA7I1J7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 211TubulinInterPro annotationAdd BLAST196
Domaini215 – 334Tubulin_CInterPro annotationAdd BLAST120

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDK. Bacteria.
COG0206. LUCA.
HOGENOMiHOG000049094.
KOiK03531.
OMAiMRAVKGI.
OrthoDBiPOG091H02KK.

Family and domain databases

CDDicd02201. FtsZ_type1. 1 hit.
Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiView protein in InterPro
IPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
PfamiView protein in Pfam
PF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiView protein in SMART
SM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiView protein in PROSITE
PS01134. FTSZ_1. 1 hit.

Sequencei

Sequence statusi: Complete.

A7I1J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGFSVEENS SVYGAKMKVI GVGGGGGNMI NHMIREGFVY DKVELIVANT
60 70 80 90 100
DAQALDKSEA KTRIQLGETK VKGLGAGGKP EVGKESAEES YDEIKNQLDY
110 120 130 140 150
ADIVFIGSGF GGGTGTGAAP VVARAAKENK SLTIGIVTTP FAFEGLKRMK
160 170 180 190 200
QAKAGIEELK KECDSIIVIP NEKLLSLVNP KEAGIKDCFK LVDNVLMRAV
210 220 230 240 250
NGMVSVIMNS GKSDVNVDFA DVKTVMSHRG IAIMGVGVSE GDEAVNEALK
260 270 280 290 300
DALQSPLLDD ISIDGAMGVL VHFRINTKCS LLEISKAMTM VQAAASDEAD
310 320 330 340 350
IIFGTTTDES IENNRVEVTL IATGFEPPKA GEKDDGGKEE PHDFRKDFIK
360 370 380
KMRAASGSDF TSDDYDEMDR EPAYTRNRMD
Length:380
Mass (Da):40,751
Last modified:September 11, 2007 - v1
Checksum:iC708E532AD004FC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000776 Genomic DNA. Translation: ABS51492.1.
RefSeqiWP_012108677.1. NC_009714.1.

Genome annotation databases

EnsemblBacteriaiABS51492; ABS51492; CHAB381_0822.
KEGGicha:CHAB381_0822.

Similar proteinsi

Entry informationi

Entry nameiA7I1J7_CAMHC
AccessioniPrimary (citable) accession number: A7I1J7
Entry historyiIntegrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: September 27, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported