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Protein

7-cyano-7-deazaguanine synthase

Gene

queC

Organism
Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ0).UniRule annotation

Catalytic activityi

7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: 7-cyano-7-deazaguanine biosynthesis

This protein is involved in the pathway 7-cyano-7-deazaguanine biosynthesis, which is part of Purine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 7-cyano-7-deazaguanine biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi187 – 1871ZincUniRule annotation
Metal bindingi195 – 1951ZincUniRule annotation
Metal bindingi198 – 1981ZincUniRule annotation
Metal bindingi201 – 2011ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 1711ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Queuosine biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciCHOM360107:GHCX-749-MONOMER.
UniPathwayiUPA00391.

Names & Taxonomyi

Protein namesi
Recommended name:
7-cyano-7-deazaguanine synthaseUniRule annotation (EC:6.3.4.20UniRule annotation)
Alternative name(s):
7-cyano-7-carbaguanine synthaseUniRule annotation
PreQ(0) synthaseUniRule annotation
Queuosine biosynthesis protein QueCUniRule annotation
Gene namesi
Name:queCUniRule annotation
Ordered Locus Names:CHAB381_0744
OrganismiCampylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A)
Taxonomic identifieri360107 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000002407 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2202207-cyano-7-deazaguanine synthasePRO_0000336902Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360107.CHAB381_0744.

Structurei

3D structure databases

ProteinModelPortaliA7I1D0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105FD2. Bacteria.
COG0603. LUCA.
HOGENOMiHOG000110564.
KOiK06920.
OMAiEKTWSCY.
OrthoDBiEOG6091HB.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_01633. QueC.
InterProiIPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF06508. QueC. 1 hit.
[Graphical view]
PIRSFiPIRSF006293. ExsB. 1 hit.
TIGRFAMsiTIGR00364. TIGR00364. 1 hit.

Sequencei

Sequence statusi: Complete.

A7I1D0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAVCVISGG MDSSTAAFIA KEQGYEILAL HFDYNQRTMK KERECFNLIC
60 70 80 90 100
DDLGVKSREI LDVSFIAQIG ANSLTDKNLT IQKTGVKSGE IPNTYVPFRN
110 120 130 140 150
GIFLSVAAAF AEKEGADALF IGVVEEDSSG YPDCSENFIK KIESAINAGT
160 170 180 190 200
SPNFKLEIKI PLVHLSKTQI VKKALEIGVP LEHTWSCYER EDKACGFCDS
210 220
CRLRLKGFKG ADTKDTIPYI
Length:220
Mass (Da):24,236
Last modified:September 11, 2007 - v1
Checksum:iE8F7DF16B8405030
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000776 Genomic DNA. Translation: ABS52375.1.
RefSeqiWP_012108609.1. NC_009714.1.

Genome annotation databases

EnsemblBacteriaiABS52375; ABS52375; CHAB381_0744.
KEGGicha:CHAB381_0744.
PATRICi20039634. VBICamHom81367_0718.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000776 Genomic DNA. Translation: ABS52375.1.
RefSeqiWP_012108609.1. NC_009714.1.

3D structure databases

ProteinModelPortaliA7I1D0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi360107.CHAB381_0744.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS52375; ABS52375; CHAB381_0744.
KEGGicha:CHAB381_0744.
PATRICi20039634. VBICamHom81367_0718.

Phylogenomic databases

eggNOGiENOG4105FD2. Bacteria.
COG0603. LUCA.
HOGENOMiHOG000110564.
KOiK06920.
OMAiEKTWSCY.
OrthoDBiEOG6091HB.

Enzyme and pathway databases

UniPathwayiUPA00391.
BioCyciCHOM360107:GHCX-749-MONOMER.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_01633. QueC.
InterProiIPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF06508. QueC. 1 hit.
[Graphical view]
PIRSFiPIRSF006293. ExsB. 1 hit.
TIGRFAMsiTIGR00364. TIGR00364. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Campylobacter hominis ATCC BAA-381, a commensal isolated from the human gastrointestinal tract."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Nelson K.E.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A.

Entry informationi

Entry nameiQUEC_CAMHC
AccessioniPrimary (citable) accession number: A7I1D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: November 11, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.