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A7I0M0

- SYL_CAMHC

UniProt

A7I0M0 - SYL_CAMHC

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Protein

Leucine--tRNA ligase

Gene
leuS, CHAB381_0473
Organism
Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei585 – 5851ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. arginine-tRNA ligase activity Source: InterPro
  3. ATP binding Source: UniProtKB-HAMAP
  4. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: InterPro
  2. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCHOM360107:GHCX-478-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:CHAB381_0473
OrganismiCampylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A)
Taxonomic identifieri360107 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000002407: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 813813Leucine--tRNA ligaseUniRule annotationPRO_0000334740Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360107.CHAB381_0473.

Structurei

3D structure databases

ProteinModelPortaliA7I0M0.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi39 – 4911"HIGH" regionUniRule annotationAdd
BLAST
Motifi582 – 5865"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR001278. Arg-tRNA-ligase.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7I0M0-1 [UniParc]FASTAAdd to Basket

« Hide

MYDSKKLELK WQEIWDKEGI FEPKKDYNLQ KKYILSMFPY PSGRIHMGHV    50
RNYTIGDAIS RYYRMQGYNV LQPIGFDSFG MPAENAAIKH KIHPKKWTYD 100
NIDYMTKELF RLGFSFSKNR ILATSDPIYT KFEQEFFIKM FEKGLIYRKN 150
AVVNWCEQDQ TVLANEQVED GKCWRCGNEV VQKEMPGYYL KITSYADELL 200
SCLKDLQNHW PSQVITMQEN WIGKSFGLEF DFKFDDESSK KLGGVKSFKV 250
FTTRPDTIYG MSYAALAPEH AVVKAVLEKN LVSKETADKI KKILNQSPRE 300
RQANDKDGAF LNLFAIHPLS GKKIPVWMAN FVLAEYGGGA VMAVPAHDER 350
DFEFAHKFNL PIIQSIGAKN GENVKLPYIE SGILVDSAEF SGLENEDAKM 400
KIIEKFEKEK IGKRVTNYKL RDWGISRQRY WGAPIPMIKC PKCGLVPEKI 450
KNLPVTLPDD IKITGKGNPL DKHPTWKHCT CPKCGAEAER ETDTLDTFFD 500
SSWYFARFTS DENMWQEKGI DEKSANYWMN VDQYIGGIEH AILHLLYARF 550
FQKVLRDLGY LRDSEPFANL LTQGMVLKDG AKMSKSKGNV VDPDEIIEKY 600
GADTARLFIL FAAPPQKELE WNDSAVEGAY KFLNRLYERS QNVQKTREIP 650
KIDQSSLNKA EKYARLKVYE ALQKSSEVYE KTFAFNTLIA ACMEALNALN 700
AQENRQILTE GYFIILNLLD PIVPHIACEL SENLFGRANF TPIKILPEVF 750
EKDEIRLAVT VNGKKRAEIE VASDLSQSEI LKIAKEQVLK WLENKKIIKE 800
IYIKNKLVNL VVK 813
Length:813
Mass (Da):93,610
Last modified:September 11, 2007 - v1
Checksum:i1022D7D868CF8EEB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000776 Genomic DNA. Translation: ABS52208.1.
RefSeqiWP_012108346.1. NC_009714.1.
YP_001406061.1. NC_009714.1.

Genome annotation databases

EnsemblBacteriaiABS52208; ABS52208; CHAB381_0473.
GeneIDi5409042.
KEGGicha:CHAB381_0473.
PATRICi20039108. VBICamHom81367_0457.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000776 Genomic DNA. Translation: ABS52208.1 .
RefSeqi WP_012108346.1. NC_009714.1.
YP_001406061.1. NC_009714.1.

3D structure databases

ProteinModelPortali A7I0M0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360107.CHAB381_0473.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS52208 ; ABS52208 ; CHAB381_0473 .
GeneIDi 5409042.
KEGGi cha:CHAB381_0473.
PATRICi 20039108. VBICamHom81367_0457.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CHOM360107:GHCX-478-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR001278. Arg-tRNA-ligase.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Campylobacter hominis ATCC BAA-381, a commensal isolated from the human gastrointestinal tract."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Nelson K.E.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A.

Entry informationi

Entry nameiSYL_CAMHC
AccessioniPrimary (citable) accession number: A7I0M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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