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A7I0M0

- SYL_CAMHC

UniProt

A7I0M0 - SYL_CAMHC

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei585 – 5851ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. arginine-tRNA ligase activity Source: InterPro
  3. ATP binding Source: UniProtKB-HAMAP
  4. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: InterPro
  2. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCHOM360107:GHCX-478-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CHAB381_0473
OrganismiCampylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A)
Taxonomic identifieri360107 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000002407: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 813813Leucine--tRNA ligasePRO_0000334740Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360107.CHAB381_0473.

Structurei

3D structure databases

ProteinModelPortaliA7I0M0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi39 – 4911"HIGH" regionAdd
BLAST
Motifi582 – 5865"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR001278. Arg-tRNA-ligase.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7I0M0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYDSKKLELK WQEIWDKEGI FEPKKDYNLQ KKYILSMFPY PSGRIHMGHV
60 70 80 90 100
RNYTIGDAIS RYYRMQGYNV LQPIGFDSFG MPAENAAIKH KIHPKKWTYD
110 120 130 140 150
NIDYMTKELF RLGFSFSKNR ILATSDPIYT KFEQEFFIKM FEKGLIYRKN
160 170 180 190 200
AVVNWCEQDQ TVLANEQVED GKCWRCGNEV VQKEMPGYYL KITSYADELL
210 220 230 240 250
SCLKDLQNHW PSQVITMQEN WIGKSFGLEF DFKFDDESSK KLGGVKSFKV
260 270 280 290 300
FTTRPDTIYG MSYAALAPEH AVVKAVLEKN LVSKETADKI KKILNQSPRE
310 320 330 340 350
RQANDKDGAF LNLFAIHPLS GKKIPVWMAN FVLAEYGGGA VMAVPAHDER
360 370 380 390 400
DFEFAHKFNL PIIQSIGAKN GENVKLPYIE SGILVDSAEF SGLENEDAKM
410 420 430 440 450
KIIEKFEKEK IGKRVTNYKL RDWGISRQRY WGAPIPMIKC PKCGLVPEKI
460 470 480 490 500
KNLPVTLPDD IKITGKGNPL DKHPTWKHCT CPKCGAEAER ETDTLDTFFD
510 520 530 540 550
SSWYFARFTS DENMWQEKGI DEKSANYWMN VDQYIGGIEH AILHLLYARF
560 570 580 590 600
FQKVLRDLGY LRDSEPFANL LTQGMVLKDG AKMSKSKGNV VDPDEIIEKY
610 620 630 640 650
GADTARLFIL FAAPPQKELE WNDSAVEGAY KFLNRLYERS QNVQKTREIP
660 670 680 690 700
KIDQSSLNKA EKYARLKVYE ALQKSSEVYE KTFAFNTLIA ACMEALNALN
710 720 730 740 750
AQENRQILTE GYFIILNLLD PIVPHIACEL SENLFGRANF TPIKILPEVF
760 770 780 790 800
EKDEIRLAVT VNGKKRAEIE VASDLSQSEI LKIAKEQVLK WLENKKIIKE
810
IYIKNKLVNL VVK
Length:813
Mass (Da):93,610
Last modified:September 11, 2007 - v1
Checksum:i1022D7D868CF8EEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000776 Genomic DNA. Translation: ABS52208.1.
RefSeqiWP_012108346.1. NC_009714.1.
YP_001406061.1. NC_009714.1.

Genome annotation databases

EnsemblBacteriaiABS52208; ABS52208; CHAB381_0473.
GeneIDi5409042.
KEGGicha:CHAB381_0473.
PATRICi20039108. VBICamHom81367_0457.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000776 Genomic DNA. Translation: ABS52208.1 .
RefSeqi WP_012108346.1. NC_009714.1.
YP_001406061.1. NC_009714.1.

3D structure databases

ProteinModelPortali A7I0M0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360107.CHAB381_0473.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS52208 ; ABS52208 ; CHAB381_0473 .
GeneIDi 5409042.
KEGGi cha:CHAB381_0473.
PATRICi 20039108. VBICamHom81367_0457.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CHOM360107:GHCX-478-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR001278. Arg-tRNA-ligase.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Campylobacter hominis ATCC BAA-381, a commensal isolated from the human gastrointestinal tract."
    Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Nelson K.E.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A.

Entry informationi

Entry nameiSYL_CAMHC
AccessioniPrimary (citable) accession number: A7I0M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: November 26, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3