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A7I0M0

- SYL_CAMHC

UniProt

A7I0M0 - SYL_CAMHC

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei585 – 5851ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. arginine-tRNA ligase activity Source: InterPro
    3. ATP binding Source: UniProtKB-HAMAP
    4. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginyl-tRNA aminoacylation Source: InterPro
    2. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCHOM360107:GHCX-478-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:CHAB381_0473
    OrganismiCampylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A)
    Taxonomic identifieri360107 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000002407: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 813813Leucine--tRNA ligasePRO_0000334740Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi360107.CHAB381_0473.

    Structurei

    3D structure databases

    ProteinModelPortaliA7I0M0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi39 – 4911"HIGH" regionAdd
    BLAST
    Motifi582 – 5865"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR001278. Arg-tRNA-ligase.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7I0M0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYDSKKLELK WQEIWDKEGI FEPKKDYNLQ KKYILSMFPY PSGRIHMGHV    50
    RNYTIGDAIS RYYRMQGYNV LQPIGFDSFG MPAENAAIKH KIHPKKWTYD 100
    NIDYMTKELF RLGFSFSKNR ILATSDPIYT KFEQEFFIKM FEKGLIYRKN 150
    AVVNWCEQDQ TVLANEQVED GKCWRCGNEV VQKEMPGYYL KITSYADELL 200
    SCLKDLQNHW PSQVITMQEN WIGKSFGLEF DFKFDDESSK KLGGVKSFKV 250
    FTTRPDTIYG MSYAALAPEH AVVKAVLEKN LVSKETADKI KKILNQSPRE 300
    RQANDKDGAF LNLFAIHPLS GKKIPVWMAN FVLAEYGGGA VMAVPAHDER 350
    DFEFAHKFNL PIIQSIGAKN GENVKLPYIE SGILVDSAEF SGLENEDAKM 400
    KIIEKFEKEK IGKRVTNYKL RDWGISRQRY WGAPIPMIKC PKCGLVPEKI 450
    KNLPVTLPDD IKITGKGNPL DKHPTWKHCT CPKCGAEAER ETDTLDTFFD 500
    SSWYFARFTS DENMWQEKGI DEKSANYWMN VDQYIGGIEH AILHLLYARF 550
    FQKVLRDLGY LRDSEPFANL LTQGMVLKDG AKMSKSKGNV VDPDEIIEKY 600
    GADTARLFIL FAAPPQKELE WNDSAVEGAY KFLNRLYERS QNVQKTREIP 650
    KIDQSSLNKA EKYARLKVYE ALQKSSEVYE KTFAFNTLIA ACMEALNALN 700
    AQENRQILTE GYFIILNLLD PIVPHIACEL SENLFGRANF TPIKILPEVF 750
    EKDEIRLAVT VNGKKRAEIE VASDLSQSEI LKIAKEQVLK WLENKKIIKE 800
    IYIKNKLVNL VVK 813
    Length:813
    Mass (Da):93,610
    Last modified:September 11, 2007 - v1
    Checksum:i1022D7D868CF8EEB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000776 Genomic DNA. Translation: ABS52208.1.
    RefSeqiWP_012108346.1. NC_009714.1.
    YP_001406061.1. NC_009714.1.

    Genome annotation databases

    EnsemblBacteriaiABS52208; ABS52208; CHAB381_0473.
    GeneIDi5409042.
    KEGGicha:CHAB381_0473.
    PATRICi20039108. VBICamHom81367_0457.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000776 Genomic DNA. Translation: ABS52208.1 .
    RefSeqi WP_012108346.1. NC_009714.1.
    YP_001406061.1. NC_009714.1.

    3D structure databases

    ProteinModelPortali A7I0M0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 360107.CHAB381_0473.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS52208 ; ABS52208 ; CHAB381_0473 .
    GeneIDi 5409042.
    KEGGi cha:CHAB381_0473.
    PATRICi 20039108. VBICamHom81367_0457.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CHOM360107:GHCX-478-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR001278. Arg-tRNA-ligase.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Campylobacter hominis ATCC BAA-381, a commensal isolated from the human gastrointestinal tract."
      Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Nelson K.E.
      Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A.

    Entry informationi

    Entry nameiSYL_CAMHC
    AccessioniPrimary (citable) accession number: A7I0M0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3