A7I0J2 (UPPP_CAMHC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	CHAB381_0437

Organism

Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A) [Complete proteome] [HAMAP]

Taxonomic identifier

360107 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter › Campylobacter hominis

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 258	258	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_1000062792
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	42 – 62	21	Helical; Potential
	Transmembrane	71 – 91	21	Helical; Potential
	Transmembrane	96 – 116	21	Helical; Potential
	Transmembrane	134 – 154	21	Helical; Potential
	Transmembrane	173 – 193	21	Helical; Potential
	Transmembrane	211 – 231	21	Helical; Potential
	Transmembrane	237 – 257	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A7I0J2 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: B84BD8218C653129	FASTA	258	28,868
	10 20 30 40 50 60 MSIIDAVILG IVEGLTEFLP VSSTGHLILT AGLLNLEQTD TLKCFEVVIQ LGSILAVVFT 70 80 90 100 110 120 FFERLKRDKQ LWIKLIIGFL PTAAIGYLLY SHIKSLFSQN VVVYMLIIWG VIFIVVELLR 130 140 150 160 170 180 KKNPPENEIL TLDGISYKQA FFIGLSQCFA MVPGTSRSGA TIIAGLLSGL NRQTAAAFSF 190 200 210 220 230 240 LLAVPTMFAA TFYDTYKNRE IFAANMDNIQ LFLLGGFVAF LVALFAIKMF LKFVSRFDYI 250 PFGIYRILIA FAFMFFVL

References

[1]

"Complete genome sequence of Campylobacter hominis ATCC BAA-381, a commensal isolated from the human gastrointestinal tract." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Nelson K.E. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000776 Genomic DNA. Translation: ABS52481.1.
RefSeq	YP_001406033.1. NC_009714.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	360107.CHAB381_0437.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABS52481; ABS52481; CHAB381_0437.
GeneID	5408094.
KEGG	cha:CHAB381_0437.
PATRIC	20039034. VBICamHom81367_0428.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218356.
KO	K06153.
OMA	LQIGLFQ.
ProtClustDB	CLSK961458.
Enzyme and pathway databases
BioCyc	CHOM360107:GHCX-487-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_CAMHC

Accession

Primary (citable) accession number: A7I0J2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	September 11, 2007
Last modified:	May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program