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A7I0J2 (UPPP_CAMHC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:CHAB381_0437
OrganismCampylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A) [Complete proteome] [HAMAP]
Taxonomic identifier360107 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 258258Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000062792

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane42 – 6221Helical; Potential
Transmembrane71 – 9121Helical; Potential
Transmembrane96 – 11621Helical; Potential
Transmembrane134 – 15421Helical; Potential
Transmembrane173 – 19321Helical; Potential
Transmembrane211 – 23121Helical; Potential
Transmembrane237 – 25721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A7I0J2 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: B84BD8218C653129

FASTA25828,868
        10         20         30         40         50         60 
MSIIDAVILG IVEGLTEFLP VSSTGHLILT AGLLNLEQTD TLKCFEVVIQ LGSILAVVFT 

        70         80         90        100        110        120 
FFERLKRDKQ LWIKLIIGFL PTAAIGYLLY SHIKSLFSQN VVVYMLIIWG VIFIVVELLR 

       130        140        150        160        170        180 
KKNPPENEIL TLDGISYKQA FFIGLSQCFA MVPGTSRSGA TIIAGLLSGL NRQTAAAFSF 

       190        200        210        220        230        240 
LLAVPTMFAA TFYDTYKNRE IFAANMDNIQ LFLLGGFVAF LVALFAIKMF LKFVSRFDYI 

       250 
PFGIYRILIA FAFMFFVL 

« Hide

References

[1]"Complete genome sequence of Campylobacter hominis ATCC BAA-381, a commensal isolated from the human gastrointestinal tract."
Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Nelson K.E.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000776 Genomic DNA. Translation: ABS52481.1.
RefSeqYP_001406033.1. NC_009714.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING360107.CHAB381_0437.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS52481; ABS52481; CHAB381_0437.
GeneID5408094.
KEGGcha:CHAB381_0437.
PATRIC20039034. VBICamHom81367_0428.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAWRKISSS.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycCHOM360107:GHCX-440-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_CAMHC
AccessionPrimary (citable) accession number: A7I0J2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families