A7I057 (KAD_CAMHC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate kinase
Short name=AK
EC=2.7.4.3

Alternative name(s):
ATP-AMP transphosphorylase

Gene names

Name:	adk
Ordered Locus Names:	CHAB381_0295

Organism

Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A) [Complete proteome] [HAMAP]

Taxonomic identifier

360107 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	192 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth By similarity. HAMAP MF_00235
Catalytic activity	ATP + AMP = 2 ADP. HAMAP MF_00235
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1. HAMAP MF_00235
Subunit structure	Monomer By similarity. HAMAP MF_00235
Subcellular location	Cytoplasm By similarity HAMAP MF_00235.
Domain	Consists of three domains, a large central CORE domain and two small peripheral domains, AMP binding and LID. The LID domain closes over the site of phosphoryl transfer upon ATP binding By similarity. HAMAP MF_00235
Sequence similarities	Belongs to the adenylate kinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 192	192	Adenylate kinase HAMAP MF_00235		PRO_1000058810
Regions
	Nucleotide binding	9 – 17	9	ATP By similarity
	Nucleotide binding	34 – 62	29	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7I057 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 2278E042E8769E57	FASTA	192	21,254
	10 20 30 40 50 60 MKNLFLIIGA PGSGKTTDAG CIAQMNQSVA HYSTGDLLRA EVAKDSELGK KIDKIISGGN 70 80 90 100 110 120 LVPLEIVINT ITSAIHACEK DFIIIDGYPR SVEQMTELDK VLANEYDINL SAVIEVNVSE 130 140 150 160 170 180 EVAKERVLGR ARGADDNEEV FYNRMKVFVE PIEEIRKFYN EKGIFHSING ERTIEEIVTD 190 INAIIVKKIV QG

References

[1]

"Complete genome sequence of Campylobacter hominis ATCC BAA-381, a commensal isolated from the human gastrointestinal tract." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Nelson K.E. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000776 Genomic DNA. Translation: ABS51102.1.
RefSeq	YP_001405898.1. NC_009714.1.
3D structure databases
ProteinModelPortal	A7I057.
ModBase	Search...
Protein-protein interaction databases
STRING	A7I057.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5409356.
GenomeReviews	Gene locus CHAB381_0295 in contig CP000776_GR.
KEGG	cha:CHAB381_0295.
NMPDR	fig|360107.5.peg.292.
PATRIC	20038754. VBICamHom81367_0291.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0563.
HOGENOM	HBG630208.
OMA	EMQKYIL.
ProtClustDB	PRK00279.
Enzyme and pathway databases
BioCyc	CHOM360107:CHAB381_0295-MONOMER.
Family and domain databases
HAMAP	MF_00235. Adenylate_kinase_Adk. [Tree]
InterPro	IPR000850. Adenylate_kin. [Graphical view]
KO	K00939.
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD_CAMHC

Accession

Primary (citable) accession number: A7I057

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	September 11, 2007
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program