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A7I002

- PNP_CAMHC

UniProt

A7I002 - PNP_CAMHC

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi494 – 4941MagnesiumUniRule annotation
    Metal bindingi500 – 5001MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciCHOM360107:GHCX-239-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:CHAB381_0237
    OrganismiCampylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A)
    Taxonomic identifieri360107 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000002407: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 711711Polyribonucleotide nucleotidyltransferasePRO_0000329570Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi360107.CHAB381_0237.

    Structurei

    3D structure databases

    ProteinModelPortaliA7I002.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini560 – 62061KHUniRule annotationAdd
    BLAST
    Domaini651 – 71060S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiPRWDWVA.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7I002-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKYAVEVNNN VEIFEINKVA KQAAGACLMK VKNTVVLATV ARENTQVEED    50
    FLPLTVQYIE KQYAAGRIPG GYIKRETKPG DFETLTSRII DRSLRPLFPK 100
    GYAYPTQIVV FVLSADPEID LQVVGLNAAS VALYLSDIPM KAPVCGVRVG 150
    YINDSFVINP TNSELQNSAL DLYVAGVKDE MLMIEMRSLP NMNGENQNMN 200
    EFSEDKMVEA IDFASKAILA GSTAYENTFS ALKKPDAALE YKPEVEDENI 250
    ANFIEQNFTS DVQAAINQMA KSERATELDK IVNKIMQSET AIQNEWQKNV 300
    VSNIIGKFKR KIIRSQIINE RRRADGRALD EIRPISIETN ILPNAHGSCL 350
    FTRGQTQALV VTTLGGETDA QVSDSLTSNT PISERFMFQY NFPGFCVGEA 400
    SPLKSPGRRE LGHGNLAKRA LTPSVPLNNP QVIRTVSEIL ESNGSSSMAS 450
    VCGGSLSLRA AGVSTLKLVA GVAMGLIFED DKHAILTDIM GLEDHDGDMD 500
    FKVAGTREGI TALQMDIKLG GISLEILREA LNQAKDGRNY ILNLMEVAND 550
    DIIINEEILP KIEIFGVDPN KMVDIIGQGG KTIKELIDKY EVSIDLERDS 600
    GEVKIQGANK INVENAKSDI LNIVKKSNDF KKGSKFGHHH ERKETSNFQV 650
    GEEFDGVVKK IMDFGAFISL KDGIDGLLHV SKIKTQLSEG DTLRVKVEEI 700
    KRGKISLELC E 711
    Length:711
    Mass (Da):78,319
    Last modified:September 11, 2007 - v1
    Checksum:i8E43C32F162016B8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000776 Genomic DNA. Translation: ABS51117.1.
    RefSeqiWP_012108124.1. NC_009714.1.
    YP_001405843.1. NC_009714.1.

    Genome annotation databases

    EnsemblBacteriaiABS51117; ABS51117; CHAB381_0237.
    GeneIDi5409225.
    KEGGicha:CHAB381_0237.
    PATRICi20038638. VBICamHom81367_0233.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000776 Genomic DNA. Translation: ABS51117.1 .
    RefSeqi WP_012108124.1. NC_009714.1.
    YP_001405843.1. NC_009714.1.

    3D structure databases

    ProteinModelPortali A7I002.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 360107.CHAB381_0237.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS51117 ; ABS51117 ; CHAB381_0237 .
    GeneIDi 5409225.
    KEGGi cha:CHAB381_0237.
    PATRICi 20038638. VBICamHom81367_0233.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi PRWDWVA.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci CHOM360107:GHCX-239-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Campylobacter hominis ATCC BAA-381, a commensal isolated from the human gastrointestinal tract."
      Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Nelson K.E.
      Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A.

    Entry informationi

    Entry nameiPNP_CAMHC
    AccessioniPrimary (citable) accession number: A7I002
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3