A7HZN3 (SYE1_CAMHC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate--tRNA ligase 1
EC=6.1.1.17

Alternative name(s):
Glutamyl-tRNA synthetase 1
Short name=GluRS 1

Gene names

Name:	gltX1
Ordered Locus Names:	CHAB381_0111

Organism

Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A) [Complete proteome] [HAMAP]

Taxonomic identifier

360107 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	462 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity. HAMAP MF_00022_B
Catalytic activity	ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). HAMAP MF_00022_B
Subunit structure	Monomer By similarity. HAMAP MF_00022_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00022_B.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glutamyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glutamate-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 462	462	Glutamate--tRNA ligase 1 HAMAP MF_00022_B		PRO_0000367636
Regions
	Motif	8 – 18	11	"HIGH" region HAMAP MF_00022_B
	Motif	237 – 241	5	"KMSKS" region HAMAP MF_00022_B
Sites
	Binding site	240	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7HZN3 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 6D2CDE352496828B	FASTA	462	52,890
	10 20 30 40 50 60 MICTRFAPSP TGYLHIGGLR TALFNYLYAR ANGGKFVLRI EDTDLKRNSV EAANAIVEAF 70 80 90 100 110 120 KWCGLDYDGE IVYQSSRFDL YKKYIQKLLD ENKAYKCYMS KAELDTLRAE QEARKERPKY 130 140 150 160 170 180 DGRYRDFNGI PPKGIDPVIR IKAPLSGTIE FDDGIKGSMK FNANDILDDF IIARSDGTPT 190 200 210 220 230 240 YNFTVVIDDA LMGITDVIRG DDHLSNTPKQ IVLYNALGFK IPKFYHVAMI NGSDGRKLSK 250 260 270 280 290 300 RHGATDVMEY KRMGYLPEAL LNFLVRLGWS HGDDEIFSLD DMKKYFDPNH ISKSSSTFNQ 310 320 330 340 350 360 SKLEWLNAYY IKNSSNKRLI KELKNFNINI ENHPKKELLI DSFKERAKTL ADMAKGIDSL 370 380 390 400 410 420 LSRPKTYEQK AFNKFINENS KNLLQKFSEI LDAQNLKAKE IEEKTMQFLE KEGEKLKNLA 430 440 450 460 QPLRVAITGT SVSPSIFEVI EILGVNEIKL RIENLIKNKE SL

References

[1]

"Complete genome sequence of Campylobacter hominis ATCC BAA-381, a commensal isolated from the human gastrointestinal tract." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Nelson K.E. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000776 Genomic DNA. Translation: ABS50888.1.
RefSeq	YP_001405724.1. NC_009714.1.
3D structure databases
ProteinModelPortal	A7HZN3.
ModBase	Search...
Protein-protein interaction databases
STRING	A7HZN3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5409460.
GenomeReviews	Gene locus CHAB381_0111 in contig CP000776_GR.
KEGG	cha:CHAB381_0111.
NMPDR	fig|360107.5.peg.108.
PATRIC	20038388. VBICamHom81367_0108.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0008.
HOGENOM	HBG628189.
OMA	NATIIEM.
ProtClustDB	PRK01406.
Enzyme and pathway databases
BioCyc	CHOM360107:CHAB381_0111-MONOMER.
Family and domain databases
HAMAP	MF_00022_B. Glu_tRNA_synth_B. [Tree]
InterPro	IPR008925. aa-tRNA-synth_I_codon-bd. IPR020751. aa-tRNA-synth_I_codon-bd_sub2. IPR001412. aa-tRNA-synth_I_CS. IPR004527. Glu-tRNA-synth_Ib_bac/mito. IPR000924. Glu/Gln-tRNA-synth_Ib. IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl. IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:1.10.1160.10. Glu/Gln-tRNA-synth_Ic_a-bdl. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 2 hits. G3DSA:1.10.10.350. tRNA_synt_bd. 1 hit.
KO	K01885.
PANTHER	PTHR10119. Glu_tRNA-synt_1c. 1 hit. PTHR10119:SF1. PTHR10119:SF1. 1 hit.
Pfam	PF00749. tRNA-synt_1c. 1 hit. [Graphical view]
PRINTS	PR00987. TRNASYNTHGLU.
SUPFAM	SSF48163. tRNA-synt_bind. 1 hit.
TIGRFAMs	TIGR00464. GltX_bact. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYE1_CAMHC

Accession

Primary (citable) accession number: A7HZN3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	September 11, 2007
Last modified:	January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program