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Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei240ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Ordered Locus Names:CHAB381_0111
OrganismiCampylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A)
Taxonomic identifieri360107 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000002407 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003676361 – 462Glutamate--tRNA ligase 1Add BLAST462

Proteomic databases

PRIDEiA7HZN3

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi360107.CHAB381_0111

Structurei

3D structure databases

ProteinModelPortaliA7HZN3
SMRiA7HZN3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi8 – 18"HIGH" regionUniRule annotationAdd BLAST11
Motifi237 – 241"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A7HZN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MICTRFAPSP TGYLHIGGLR TALFNYLYAR ANGGKFVLRI EDTDLKRNSV
60 70 80 90 100
EAANAIVEAF KWCGLDYDGE IVYQSSRFDL YKKYIQKLLD ENKAYKCYMS
110 120 130 140 150
KAELDTLRAE QEARKERPKY DGRYRDFNGI PPKGIDPVIR IKAPLSGTIE
160 170 180 190 200
FDDGIKGSMK FNANDILDDF IIARSDGTPT YNFTVVIDDA LMGITDVIRG
210 220 230 240 250
DDHLSNTPKQ IVLYNALGFK IPKFYHVAMI NGSDGRKLSK RHGATDVMEY
260 270 280 290 300
KRMGYLPEAL LNFLVRLGWS HGDDEIFSLD DMKKYFDPNH ISKSSSTFNQ
310 320 330 340 350
SKLEWLNAYY IKNSSNKRLI KELKNFNINI ENHPKKELLI DSFKERAKTL
360 370 380 390 400
ADMAKGIDSL LSRPKTYEQK AFNKFINENS KNLLQKFSEI LDAQNLKAKE
410 420 430 440 450
IEEKTMQFLE KEGEKLKNLA QPLRVAITGT SVSPSIFEVI EILGVNEIKL
460
RIENLIKNKE SL
Length:462
Mass (Da):52,890
Last modified:September 11, 2007 - v1
Checksum:i6D2CDE352496828B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000776 Genomic DNA Translation: ABS50888.1
RefSeqiWP_011991571.1, NC_009714.1

Genome annotation databases

EnsemblBacteriaiABS50888; ABS50888; CHAB381_0111
KEGGicha:CHAB381_0111

Similar proteinsi

Entry informationi

Entry nameiSYE1_CAMHC
AccessioniPrimary (citable) accession number: A7HZN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 11, 2007
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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