Reviewed, UniProtKB/Swiss-Prot A7HZE0 (NTPA_CAMHC)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

CHAB381_0009

Organism

Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A) [Complete proteome] [HAMAP]

Taxonomic identifier

360107 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H2O = NDP + phosphate. HAMAP MF_01405
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Nucleoside-triphosphatase HAMAP MF_01405		PRO_1000068412

Sequences

	Sequence		Length	Mass (Da)
	A7HZE0-1 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: B54A3E94DEBC7387	FASTA	206	23,253
	10 20 30 40 50 60 MKIILATSNK DKVKEIKAFY KNYEIYALNE IMQPFEIKET GSSFKENALI KVNAVYKKLE 70 80 90 100 110 120 EMKLENEFMA LSDDSGICVD ILGGAPGIYS ARYSNDMVIH PTDESNRAKL ISKLHKKNVK 130 140 150 160 170 180 TSPAHYTACI ALSCKSGNFT THGFMHGRVI DEERGNNGFG YDFMFIANGF SKTIGELDEN 190 200 TKLKISHRSK GLFLMSKILK ILNRSF

References

[1]

"Complete genome sequence of Campylobacter hominis ATCC BAA-381, a commensal isolated from the human gastrointestinal tract." Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G., Mandrell R.E., Nelson K.E. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000776 Genomic DNA. Translation: ABS52222.1.
RefSeq	YP_001405631.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5408577.
GenomeReviews	Gene locus CHAB381_0009 in contig CP000776_GR.
KEGG	cha:CHAB381_0009.
NMPDR	fig|360107.5.peg.9.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A7HZE0. NACLKAS.
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p-like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NTPA_CAMHC

Accession

Primary (citable) accession number: A7HZE0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	September 11, 2007
Last modified:	June 16, 2009
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)