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A7HYU8

- A7HYU8_PARL1

UniProt

A7HYU8 - A7HYU8_PARL1

Protein

Alanine racemase

Gene

Plav_3482

Organism
Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei57 – 571Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei153 – 1531SubstrateUniRule annotation
    Active sitei279 – 2791Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei338 – 3381Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciPLAV402881:GHQA-3528-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:Plav_3482Imported
    OrganismiParvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)Imported
    Taxonomic identifieri402881 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhodobiaceaeParvibaculum
    ProteomesiUP000006377: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei57 – 571N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi402881.Plav_3482.

    Structurei

    3D structure databases

    ProteinModelPortaliA7HYU8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031445.
    KOiK01775.
    OMAiPSECAGV.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7HYU8-1 [UniParc]FASTAAdd to Basket

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    MIARAFLRFT KRAPVIGTDT DLAAAGGLLT IDLDAVAANY DMLRAEAAGA    50
    EVSAVVKANA YGLGMGPVAR RLAAEGCRSF FVAEANEGAA LRALLPDAEI 100
    YVLNGLFPGT AGFYAAHGLV PCLASMAEVA EWREAAKGGS LKAALHFDTG 150
    MNRLGMSEAD AAALAAEGAL TAGIEVRLIM SHLACADDAA SPMNARQLAR 200
    FRGLRTILAG RFAGAKASLA NSGGIYLGKD YHFDLVRPGV SLYGGSPFTG 250
    REHPFRPAVT VEARVLAVRE MAAEETAGYG ATWKARGTAR MAVLAAGYAD 300
    GYMRALSSPR PNGDGGDDYG GQVRIAGYTA PVAGRISMDM LIVDVSGLPE 350
    GAVKRGDMAE LIGPHITVDD VGLKAGTLGY EILTSLGGRY MRIYVSGGKA 400
    MTEGGGRV 408
    Length:408
    Mass (Da):42,269
    Last modified:September 11, 2007 - v1
    Checksum:iAE59AFBAFE7518CE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000774 Genomic DNA. Translation: ABS65081.1.
    RefSeqiWP_012112393.1. NC_009719.1.
    YP_001414738.1. NC_009719.1.

    Genome annotation databases

    EnsemblBacteriaiABS65081; ABS65081; Plav_3482.
    GeneIDi5454952.
    KEGGipla:Plav_3482.
    PATRICi22868767. VBIParLav90819_3587.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000774 Genomic DNA. Translation: ABS65081.1 .
    RefSeqi WP_012112393.1. NC_009719.1.
    YP_001414738.1. NC_009719.1.

    3D structure databases

    ProteinModelPortali A7HYU8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 402881.Plav_3482.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS65081 ; ABS65081 ; Plav_3482 .
    GeneIDi 5454952.
    KEGGi pla:Plav_3482.
    PATRICi 22868767. VBIParLav90819_3587.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031445.
    KOi K01775.
    OMAi PSECAGV.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci PLAV402881:GHQA-3528-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence and annotation of Parvibaculum lavamentivorans DS-1."
      Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.
      Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DS-1 / DSM 13023 / NCIMB 13966Imported.

    Entry informationi

    Entry nameiA7HYU8_PARL1
    AccessioniPrimary (citable) accession number: A7HYU8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 11, 2007
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3