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Protein

Fructose-1,6-bisphosphatase class 1

Gene

fbp

Organism
Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi91 – 911Magnesium 1UniRule annotation
Metal bindingi113 – 1131Magnesium 1UniRule annotation
Metal bindingi113 – 1131Magnesium 2UniRule annotation
Metal bindingi115 – 1151Magnesium 1; via carbonyl oxygenUniRule annotation
Metal bindingi116 – 1161Magnesium 2UniRule annotation
Binding sitei210 – 2101SubstrateUniRule annotation
Binding sitei276 – 2761SubstrateUniRule annotation
Metal bindingi282 – 2821Magnesium 2UniRule annotation

GO - Molecular functioni

  1. fructose 1,6-bisphosphate 1-phosphatase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciPLAV402881:GHQA-3329-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-1,6-bisphosphatase class 1UniRule annotation (EC:3.1.3.11UniRule annotation)
Short name:
FBPase class 1UniRule annotation
Alternative name(s):
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1UniRule annotation
Gene namesi
Name:fbpUniRule annotation
Ordered Locus Names:Plav_3283
OrganismiParvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Taxonomic identifieri402881 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhodobiaceaeParvibaculum
ProteomesiUP000006377 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Fructose-1,6-bisphosphatase class 1PRO_0000364620Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi402881.Plav_3283.

Structurei

3D structure databases

ProteinModelPortaliA7HYA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni116 – 1194Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the FBPase class 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0158.
HOGENOMiHOG000191264.
KOiK03841.
OMAiYANDKFK.
OrthoDBiEOG6X10TR.

Family and domain databases

HAMAPiMF_01855. FBPase_class1.
InterProiIPR000146. FBPase_class-1/SBPase.
IPR028343. FBPtase.
[Graphical view]
PANTHERiPTHR11556. PTHR11556. 1 hit.
PfamiPF00316. FBPase. 1 hit.
[Graphical view]
PIRSFiPIRSF500210. FBPtase. 1 hit.
PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTSiPR00115. F16BPHPHTASE.

Sequencei

Sequence statusi: Complete.

A7HYA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQRTLTQFL IEQQRKEAAL PAQLRLLVEI VARACKTISH CVNKGALGGM
60 70 80 90 100
LGNLTSENVQ GEVQKKLDVI ANEKLLEANE WGGHLAAMAS EEMETIHLIP
110 120 130 140 150
NRYPKGEYLL LFDPIDGSSN IDVDLSVGTI FSVLTAPEDV SGRAVTEADF
160 170 180 190 200
LQPGRKQVAA GYAIYGPQTL LILSVGTGVY EFALDREMGS WVLTNERIRI
210 220 230 240 250
PSGNREFAIN MSNMRHWAPP VRRYIDECLA GTTGPREANF NMRWTASMVA
260 270 280 290 300
DIHRILKRGG IFMYPWDARE PDRAGKLRLM YEANPMGFLI EQAGGMAFDG
310 320 330 340
NHRILDIEPK ALHQRVGVVM GDRDEVKRVV QYHHDANLAK QTA
Length:343
Mass (Da):38,228
Last modified:September 11, 2007 - v1
Checksum:i5C74BD12671D485A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000774 Genomic DNA. Translation: ABS64888.1.
RefSeqiWP_012112216.1. NC_009719.1.
YP_001414545.1. NC_009719.1.

Genome annotation databases

EnsemblBacteriaiABS64888; ABS64888; Plav_3283.
KEGGipla:Plav_3283.
PATRICi22868379. VBIParLav90819_3393.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000774 Genomic DNA. Translation: ABS64888.1.
RefSeqiWP_012112216.1. NC_009719.1.
YP_001414545.1. NC_009719.1.

3D structure databases

ProteinModelPortaliA7HYA5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi402881.Plav_3283.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS64888; ABS64888; Plav_3283.
KEGGipla:Plav_3283.
PATRICi22868379. VBIParLav90819_3393.

Phylogenomic databases

eggNOGiCOG0158.
HOGENOMiHOG000191264.
KOiK03841.
OMAiYANDKFK.
OrthoDBiEOG6X10TR.

Enzyme and pathway databases

UniPathwayiUPA00138.
BioCyciPLAV402881:GHQA-3329-MONOMER.

Family and domain databases

HAMAPiMF_01855. FBPase_class1.
InterProiIPR000146. FBPase_class-1/SBPase.
IPR028343. FBPtase.
[Graphical view]
PANTHERiPTHR11556. PTHR11556. 1 hit.
PfamiPF00316. FBPase. 1 hit.
[Graphical view]
PIRSFiPIRSF500210. FBPtase. 1 hit.
PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTSiPR00115. F16BPHPHTASE.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence and annotation of Parvibaculum lavamentivorans DS-1."
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DS-1 / DSM 13023 / NCIMB 13966.

Entry informationi

Entry nameiF16PA_PARL1
AccessioniPrimary (citable) accession number: A7HYA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: September 11, 2007
Last modified: April 1, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.