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A7HWM6

- NADK_PARL1

UniProt

A7HWM6 - NADK_PARL1

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Protein

NAD kinase

Gene

nadK

Organism
Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441Proton acceptorUniRule annotation
Binding sitei144 – 1441NADUniRule annotation
Binding sitei152 – 1521NAD; via carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi44 – 452NADUniRule annotation
Nucleotide bindingi114 – 1152NADUniRule annotation
Nucleotide bindingi155 – 1606NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciPLAV402881:GHQA-2731-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Plav_2701
OrganismiParvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Taxonomic identifieri402881 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhodobiaceaeParvibaculum
ProteomesiUP000006377: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255NAD kinasePRO_1000072085Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi402881.Plav_2701.

Structurei

3D structure databases

ProteinModelPortaliA7HWM6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000139847.
KOiK00858.
OMAiHESTVSI.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

A7HWM6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFEKIAFVA TEMPEAEAAR KALSRRYGDA KPEEADVIVA LGGDGLMLQT
60 70 80 90 100
MHQHMKRRIP IYGMNRGSVG FLMNEYRDDN LTERLAAAEC ATIHPLRMRA
110 120 130 140 150
SLADGSCHEA LAINEVALFR ETYQAAKIRI SIDGKTRMEE LVCDGVLVAT
160 170 180 190 200
PAGSTAYNLS AQGPIVPIDA ALLALTPISA FRPRRWRGAL LSHRAQLRFE
210 220 230 240 250
ILEAEKRPVS AVADHTEFRQ VREVEVEEDG SIDMLMLFDP DHGLEERIIT

EQFLY
Length:255
Mass (Da):28,512
Last modified:September 11, 2007 - v1
Checksum:iC233FFBEBDBB1BFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000774 Genomic DNA. Translation: ABS64309.1.
RefSeqiWP_012111624.1. NC_009719.1.
YP_001413966.1. NC_009719.1.

Genome annotation databases

EnsemblBacteriaiABS64309; ABS64309; Plav_2701.
GeneIDi5456914.
KEGGipla:Plav_2701.
PATRICi22867139. VBIParLav90819_2790.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000774 Genomic DNA. Translation: ABS64309.1 .
RefSeqi WP_012111624.1. NC_009719.1.
YP_001413966.1. NC_009719.1.

3D structure databases

ProteinModelPortali A7HWM6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 402881.Plav_2701.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS64309 ; ABS64309 ; Plav_2701 .
GeneIDi 5456914.
KEGGi pla:Plav_2701.
PATRICi 22867139. VBIParLav90819_2790.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000139847.
KOi K00858.
OMAi HESTVSI.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci PLAV402881:GHQA-2731-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence and annotation of Parvibaculum lavamentivorans DS-1."
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DS-1 / DSM 13023 / NCIMB 13966.

Entry informationi

Entry nameiNADK_PARL1
AccessioniPrimary (citable) accession number: A7HWM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 11, 2007
Last modified: November 26, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3