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Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (Plav_2597)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPLAV402881:G1G9L-2633-MONOMER
UniPathwayiUPA00074; UER00131

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthaseUniRule annotation (EC:6.3.2.6UniRule annotation)
Alternative name(s):
SAICAR synthetaseUniRule annotation
Gene namesi
Name:purCUniRule annotation
Ordered Locus Names:Plav_2589
OrganismiParvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Taxonomic identifieri402881 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhodobiaceaeParvibaculum
Proteomesi
  • UP000006377 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000714481 – 253Phosphoribosylaminoimidazole-succinocarboxamide synthaseAdd BLAST253

Proteomic databases

PRIDEiA7HWB4

Interactioni

Protein-protein interaction databases

STRINGi402881.Plav_2589

Structurei

3D structure databases

ProteinModelPortaliA7HWB4
SMRiA7HWB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAICAR synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QPR Bacteria
COG0152 LUCA
HOGENOMiHOG000082629
KOiK01923
OMAiFNAQKRG
OrthoDBiPOG091H02H7

Family and domain databases

CDDicd01415 SAICAR_synt_PurC, 1 hit
HAMAPiMF_00137 SAICAR_synth, 1 hit
InterProiView protein in InterPro
IPR028923 SAICAR_synt/ADE2_N
IPR033934 SAICAR_synt_PurC
IPR001636 SAICAR_synth
PfamiView protein in Pfam
PF01259 SAICAR_synt, 1 hit
TIGRFAMsiTIGR00081 purC, 1 hit

Sequencei

Sequence statusi: Complete.

A7HWB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRRRVYEG KAKVLYEGPE PGTLIQHFKD DATAFDAQKR ATIEGKGVLN
60 70 80 90 100
NRISEFIFTR LNEIGVPTHF IRALNMREQL IREVEIIPCE VVVRNVAAGS
110 120 130 140 150
LSKRLGIDEG TVLPRSIIEF YYKNDELHDP MVSEEHITAF GWATPQEIDD
160 170 180 190 200
MMALALRIND FLTGLFLGIG IRLVDFKVEF GRLYEGEMVR VVLADEISPD
210 220 230 240 250
CCRLWDTRTN DKMDKDRFRR DMGGLIEAYS EVARRLGILF ENEPKRSGPK

LVK
Length:253
Mass (Da):29,023
Last modified:September 11, 2007 - v1
Checksum:i468E444FFAD24FD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000774 Genomic DNA Translation: ABS64197.1
RefSeqiWP_012111509.1, NC_009719.1

Genome annotation databases

EnsemblBacteriaiABS64197; ABS64197; Plav_2589
KEGGipla:Plav_2589

Entry informationi

Entry nameiPUR7_PARL1
AccessioniPrimary (citable) accession number: A7HWB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 11, 2007
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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