A7HW57 (A7HW57_PARL1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Error-prone DNA polymerase HAMAP MF_01902
EC=2.7.7.7 HAMAP MF_01902

Gene names

Name:	dnaE2 HAMAP MF_01902
Ordered Locus Names:	Plav_2531

Organism

Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966) [Complete proteome] [HAMAP]

Taxonomic identifier

402881 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Parvibaculum

Protein attributes

Sequence length	1085 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase By similarity. HAMAP MF_01902
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP MF_01902 SAAS SAAS004013
Subcellular location	Cytoplasm By similarity HAMAP MF_01902 SAAS SAAS004013.
Sequence similarities	Belongs to the DNA polymerase type-C family. DnaE2 subfamily. HAMAP MF_01902

Ontologies

Keywords
Biological process	DNA damage DNA repair HAMAP MF_01902 SAAS SAAS004013 DNA replication HAMAP MF_01902 SAAS SAAS004013
Cellular component	Cytoplasm HAMAP MF_01902 SAAS SAAS004013
Domain	Signal EMBL ABS64140.1
Molecular function	DNA-directed DNA polymerase HAMAP MF_01902 SAAS SAAS004013 Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: HAMAP DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential EMBL ABS64140.1
	Chain	25 – 1085	1061	Potential EMBL ABS64140.1		PRO_5000267706

Sequences

	Sequence		Length	Mass (Da)
	A7HW57 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 80D37A6439110199	FASTA	1,085	121,091
	10 20 30 40 50 60 MSASFAELAV ATNFSFLRGA SHAEELVLAA KAQGLSAIGI ADRNTLAGIV RAHAAAKEEK 70 80 90 100 110 120 IRLLVGARLV LQDGFEVIAY PQDRAAYGRL TRLLTLGNRR APKGECFLAM SDLLEHGEGH 130 140 150 160 170 180 CFIAMPPPVP DEDFEAKLRL IAETFPDSIW LGLTPFYRAD DVRRHHVLEL LARKTQVPLV 190 200 210 220 230 240 ATNDVLYHSP DRKPLHDVVT CVREHCTLKE AGFRLAANAE RHVKSPEEMS RLLAHVPKAL 250 260 270 280 290 300 SATFDIVERC SFSLEELRYE YPADNFSEHE TPQELLVRLT WEGARDFFSQ GVDDKIRKAI 310 320 330 340 350 360 DHELKLIEEM AYAPYFLTVH DIVRYARSQN ILCQGRGSAA NSTVCFCLGI TSVNPSEIDL 370 380 390 400 410 420 LFERFISKDR NEPPDIDVDF EHERREEVIQ YIYEKYGRHR AGIAATVISY RSRSAIRDVG 430 440 450 460 470 480 KVFGLSEDVI SALSRSTWGW SSSGVSQKDA REIGLDPSDR RLRLALKLAG ELIGFPRHLS 490 500 510 520 530 540 QHVGGFVITK GPLDEVVPIQ NAAMDDRTFV EWDKDDLDTL GILKIDVLAL GMLTCIRKAF 550 560 570 580 590 600 EFIEKHYARP MTLAGVPQGD KAVYDMLCEA DAIGVFQVES RAQMSMLPRL KPRNFYDLVV 610 620 630 640 650 660 EVAIVRPGPI QGDMVHPYLR RRSGKEEITY PSSVLEEVLE RTYGVPLFQE QAMKIAIVAA 670 680 690 700 710 720 GFTPGESDQL RRAMATFRKS GTIGMYRDKF IAGMLKNGYK QDFAERCFKQ IEGFADYGFP 730 740 750 760 770 780 ESHAASFARL AYISAWLKYH YPDAFCAALL NSQPMGFYAP AQLVRDASEH GVEVRPVDVN 790 800 810 820 830 840 HSDWDCTLEK TTGGKCAVRL GLRQVKGVQI ATGETIEGKR GKGFDSIRHL WLKTGLGPRV 850 860 870 880 890 900 IEKLADADAF RSIGFDRREA LWAVRGLGGY GNGQNGTTPA ALPLFATLEE GGLQVEEDVS 910 920 930 940 950 960 LPAMPPGEHV VLDYAMLRLS LKAHPISFLR PRFAACGAIS SRQLKETEAG KRISIAGLVL 970 980 990 1000 1010 1020 VRQRPGTASG VIFATLEDET GIANIIIWPK LYEKRRRIVL TSRLLFVRGR IQKEGIVIHI 1030 1040 1050 1060 1070 1080 VADDLEDWTH ELAHLSSEAD IGEALISPAD GVKHPGQDPR DGNHTREEQK RMRAARFVPK SRDFH

References

[1]

"Complete genome sequence and annotation of Parvibaculum lavamentivorans DS-1." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DS-1 / DSM 13023 / NCIMB 13966.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000774 Genomic DNA. Translation: ABS64140.1.
RefSeq	YP_001413797.1. NC_009719.1.
3D structure databases
ProteinModelPortal	A7HW57.
ModBase	Search...
Protein-protein interaction databases
STRING	A7HW57.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5456012.
GenomeReviews	Gene locus Plav_2531 in contig CP000774_GR.
KEGG	pla:Plav_2531.
PATRIC	22866785. VBIParLav90819_2614.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0587.
HOGENOM	HBG734490.
OMA	EQPAIRL.
Family and domain databases
HAMAP	MF_01902. DNApol_error_prone. [Tree]
InterPro	IPR011708. DNA_pol3_alpha. IPR023073. DNA_pol_error_prone. IPR004365. NA-bd_OB_tRNA-helicase. IPR004013. PHP_C. IPR003141. Pol/His_phosphatase_N. IPR016195. Pol/histidinol_Pase-like. IPR004805. PolC_alpha. [Graphical view]
KO	K14162.
Pfam	PF07733. DNA_pol3_alpha. 1 hit. PF02811. PHP. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
SMART	SM00481. POLIIIAc. 1 hit. [Graphical view]
SUPFAM	SSF89550. PHP-like. 1 hit.
TIGRFAMs	TIGR00594. Polc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A7HW57_PARL1

Accession

Primary (citable) accession number: A7HW57

Entry history

Integrated into UniProtKB/TrEMBL:	September 11, 2007
Last sequence update:	September 11, 2007
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)