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A7HVJ5 (A7HVJ5_PARL1) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Carbamoyl-phosphate synthase small chain HAMAP-Rule MF_01209
EC=6.3.5.5 HAMAP-Rule MF_01209
Alternative name(s):
Carbamoyl-phosphate synthetase glutamine chain HAMAP-Rule MF_01209
Gene names
Name:carA HAMAP-Rule MF_01209
Ordered Locus Names:Plav_2314
OrganismParvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966) [Complete proteome] [HAMAP] EMBL ABS63928.1
Taxonomic identifier402881 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Parvibaculum ›

Protein attributes

Sequence length402 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. HAMAP-Rule MF_01209

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1. HAMAP-Rule MF_01209

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3. HAMAP-Rule MF_01209 SAAS SAAS006274

Subunit structure

Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate By similarity. HAMAP-Rule MF_01209

Sequence similarities

Belongs to the CarA family. HAMAP-Rule MF_01209

Contains 1 glutamine amidotransferase type-1 domain. HAMAP-Rule MF_01209

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain216 – 402187Glutamine amidotransferase type-1 By similarity HAMAP-Rule MF_01209
Region1 – 212212CPSase By similarity HAMAP-Rule MF_01209

Sites

Active site2931Nucleophile By similarity HAMAP-Rule MF_01209
Active site3771 By similarity HAMAP-Rule MF_01209
Active site3791 By similarity HAMAP-Rule MF_01209

Sequences

Sequence LengthMass (Da)Tools
A7HVJ5 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 2112DC8E4841343D

FASTA40243,308
        10         20         30         40         50         60 
MSAPSSDKPI NATSSPMTAT ETPTALLVLK DGTVLPGRGI GAVGDAVGEV CFNTAITGYQ 

        70         80         90        100        110        120 
EILTDPSYAG QIITFTFPHI GNVGTNDEDI ETSNLASLSG VRGMVIRADI TSPSNYRSAK 

       130        140        150        160        170        180 
HLDQWLKTRG IIGLSGLDTR ALTRRIREKG SIDGLIAHDP SGKFDIPALI AKAREWPGMV 

       190        200        210        220        230        240 
GLDLVKDVTC GQSYTWNEAR WRWGCGYEPG HEMKHRVVAI DYGIKRNILR CLTSTGCEVT 

       250        260        270        280        290        300 
VVPAETKAED ILAMNPDGVF LSNGPGDPAA TGEYAVPEIK KLVASGKPVF GICLGHQMLA 

       310        320        330        340        350        360 
LALGAKTEKM HQGHHGANHP VKDYTTGKVE ITSMNHGFAV SRESLPGTVE ETHVSLFDGS 

       370        380        390        400 
NCGIRLKDRP VFSVQYHPEA SPGPMDSHYL FERFVKLIEE GK

« Hide

References

[1]"Complete genome sequence and annotation of Parvibaculum lavamentivorans DS-1."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DS-1 / DSM 13023 / NCIMB 13966.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000774 Genomic DNA. Translation: ABS63928.1.
RefSeqYP_001413585.1. NC_009719.1.

3D structure databases

ProteinModelPortalA7HVJ5.
SMRA7HVJ5. Positions 24-402.
ModBaseSearch...

Protein-protein interaction databases

STRING402881.Plav_2314.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS63928; ABS63928; Plav_2314.
GeneID5454561.
KEGGpla:Plav_2314.
PATRIC22866331. VBIParLav90819_2389.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0505.
HOGENOMHOG000038087.
KOK01956.
OMARDSHYLF.
ProtClustDBCLSK2793802.

Enzyme and pathway databases

BioCycPLAV402881:GHQA-2363-MONOMER.
UniPathwayUPA00068; UER00171.
UPA00070; UER00115.

Family and domain databases

Gene3D3.50.30.20. 1 hit.
HAMAPMF_01209. CPSase_S_chain.
InterProIPR006274. CarbamoylP_synth_ssu.
IPR002474. CarbamoylP_synth_ssu_N.
IPR017926. GATASE_1.
[Graphical view]
PfamPF00988. CPSase_sm_chain. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SMARTSM01097. CPSase_sm_chain. 1 hit.
[Graphical view]
SUPFAMSSF52021. CP_synthsmall. 1 hit.
TIGRFAMsTIGR01368. CPSaseIIsmall. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA7HVJ5_PARL1
AccessionPrimary (citable) accession number: A7HVJ5
Entry history
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: May 1, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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