Skip Header

Contribute Send feedback
Read comments (?) or add your own

A7HVC1 (A7HVC1_PARL1) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Coproporphyrinogen-III oxidase, aerobic HAMAP MF_00333
Short name=Coprogen oxidase HAMAP MF_00333
Short name=Coproporphyrinogenase HAMAP MF_00333
EC=1.3.3.3 HAMAP MF_00333
Gene names
Name:hemF HAMAP MF_00333
Ordered Locus Names:Plav_2240
OrganismParvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966) [Complete proteome] [HAMAP]
Taxonomic identifier402881 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Parvibaculum

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. HAMAP MF_00333 SAAS SAAS018375

Catalytic activity

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. HAMAP MF_00333 SAAS SAAS018375

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. HAMAP MF_00333 SAAS SAAS018375

Subunit structure

Homodimer By similarity. HAMAP MF_00333 SAAS SAAS018375

Subcellular location

Cytoplasm By similarity HAMAP MF_00333.

Sequence similarities

Belongs to the aerobic coproporphyrinogen-III oxidase family. HAMAP MF_00333

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region78 – 8710Important for dimerization By similarity HAMAP MF_00333
Region138 – 1403Substrate binding By similarity HAMAP MF_00333
Region269 – 30436Important for dimerization By similarity HAMAP MF_00333
Region287 – 2926Substrate binding By similarity HAMAP MF_00333

Sites

Active site1361Proton donor By similarity HAMAP MF_00333
Binding site1221Substrate By similarity HAMAP MF_00333
Site2041Important for dimerization By similarity HAMAP MF_00333

Sequences

Sequence LengthMass (Da)Tools
A7HVC1 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: E52AC76ED82FBEDD

FASTA30435,242
        10         20         30         40         50         60 
MTMLQRNVPA MDKTDGTTER KARAESWFRE LRDLICAEFE KLEDELTGTF ADRPAGRFER 

        70         80         90        100        110        120 
TPWKRGDGSR DEGGGEMSVM HGRVFEKVGV HISTVHGEFS EDFRKQMQGA EEDPRFWASG 

       130        140        150        160        170        180 
ISLIAHMQNP RVPAVHMNTR HVYTTKSWFG GGGDLTPVLD VQRRDDHPDT VDFHAAYKRA 

       190        200        210        220        230        240 
CDRHDADYYP KFKKWCDEYF FLPHRNEPRG TGGIFYDHHN SGDWEKDFAF TQDVGRAFLE 

       250        260        270        280        290        300 
IYPELVRRHM NEAWTEAERE EQLVRRGRYV EFNLLYDRGT VFGLKTGGNV NSILSSMPPA 


VKWP

« Hide

References

[1]"Complete genome sequence and annotation of Parvibaculum lavamentivorans DS-1."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DS-1 / DSM 13023 / NCIMB 13966.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000774 Genomic DNA. Translation: ABS63854.1.
RefSeqYP_001413511.1. NC_009719.1.

3D structure databases

ProteinModelPortalA7HVC1.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7HVC1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5454791.
GenomeReviewsGene locus Plav_2240 in contig CP000774_GR.
KEGGpla:Plav_2240.
PATRIC22866179. VBIParLav90819_2313.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0408.
HOGENOMHBG631180.
OMAVKAYLLD.
ProtClustDBPRK05330.

Family and domain databases

HAMAPMF_00333. Coprogen_oxidas.
[Tree]
InterProIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
Gene3DG3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
KOK00228.
PANTHERPTHR10755. Coprogen_oxidas. 1 hit.
PfamPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PIRSFPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSPR00073. COPRGNOXDASE.
SUPFAMSSF102886. Coprogen_oxidas. 1 hit.
PROSITEPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA7HVC1_PARL1
AccessionPrimary (citable) accession number: A7HVC1
Entry history
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info