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Protein

NAD(P)H dehydrogenase (quinone)

Gene

Plav_2222

Organism
Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

NAD(P)H + a quinone = NAD(P)+ + a hydroquinone.UniRule annotation

Cofactori

FMNUniRule annotationNote: Binds 1 FMN per monomer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151NAD(P)UniRule annotation
Binding sitei54 – 541NAD(P); via carbonyl oxygenUniRule annotation
Binding sitei102 – 1021SubstrateUniRule annotation
Binding sitei137 – 1371FMNUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 175FMNUniRule annotation
Nucleotide bindingi114 – 16653FMNUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciPLAV402881:GHQA-2250-MONOMER.

Protein family/group databases

CAZyiAA6. Auxiliary Activities 6.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD(P)H dehydrogenase (quinone)UniRule annotation (EC:1.6.5.2UniRule annotation)
Alternative name(s):
Flavoprotein WrbA
NAD(P)H:quinone oxidoreductaseUniRule annotation
Short name:
NQOUniRule annotation
Gene namesi
Ordered Locus Names:Plav_2222
OrganismiParvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Taxonomic identifieri402881 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhodobiaceaeParvibaculum
Proteomesi
  • UP000006377 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203NAD(P)H dehydrogenase (quinone)PRO_1000084144Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi402881.Plav_2222.

Structurei

3D structure databases

ProteinModelPortaliA7HVA3.
SMRiA7HVA3. Positions 6-201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 195189Flavodoxin-likeUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the WrbA family.UniRule annotation
Contains 1 flavodoxin-like domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CS1. Bacteria.
COG0655. LUCA.
HOGENOMiHOG000030539.
KOiK03809.
OMAiDTAGPLW.
OrthoDBiPOG091H03V0.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
HAMAPiMF_01017. NQOR. 1 hit.
InterProiIPR008254. Flavodoxin/NO_synth.
IPR029039. Flavoprotein-like_dom.
IPR010089. Flavoprotein_WrbA.
IPR005025. FMN_Rdtase-like.
[Graphical view]
PfamiPF03358. FMN_red. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
TIGRFAMsiTIGR01755. flav_wrbA. 1 hit.
PROSITEiPS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7HVA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGKTKVLVL YHSSYGHIET LAKAVAEGAA SQAGTEVLLK RVPETMPADA
60 70 80 90 100
MANAGMKVEQ EAPVATPQEL GDYDAVIFGT PTRFGNMTGQ MRTFLDQTGG
110 120 130 140 150
LWAKGALVGK VGSVFTSTGT GGGNETTITS FHTNLFHHGM VVVGLPYSVG
160 170 180 190 200
TELFDISEVR GGSPYGASTL AGGDGKRQPT EKELSLARKQ GAHVASIAAK

LKA
Length:203
Mass (Da):21,099
Last modified:September 11, 2007 - v1
Checksum:iC52BC1A0963C9B21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000774 Genomic DNA. Translation: ABS63836.1.
RefSeqiWP_012111141.1. NC_009719.1.

Genome annotation databases

EnsemblBacteriaiABS63836; ABS63836; Plav_2222.
KEGGipla:Plav_2222.
PATRICi22866139. VBIParLav90819_2293.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000774 Genomic DNA. Translation: ABS63836.1.
RefSeqiWP_012111141.1. NC_009719.1.

3D structure databases

ProteinModelPortaliA7HVA3.
SMRiA7HVA3. Positions 6-201.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi402881.Plav_2222.

Protein family/group databases

CAZyiAA6. Auxiliary Activities 6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS63836; ABS63836; Plav_2222.
KEGGipla:Plav_2222.
PATRICi22866139. VBIParLav90819_2293.

Phylogenomic databases

eggNOGiENOG4105CS1. Bacteria.
COG0655. LUCA.
HOGENOMiHOG000030539.
KOiK03809.
OMAiDTAGPLW.
OrthoDBiPOG091H03V0.

Enzyme and pathway databases

BioCyciPLAV402881:GHQA-2250-MONOMER.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
HAMAPiMF_01017. NQOR. 1 hit.
InterProiIPR008254. Flavodoxin/NO_synth.
IPR029039. Flavoprotein-like_dom.
IPR010089. Flavoprotein_WrbA.
IPR005025. FMN_Rdtase-like.
[Graphical view]
PfamiPF03358. FMN_red. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
TIGRFAMsiTIGR01755. flav_wrbA. 1 hit.
PROSITEiPS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNQOR_PARL1
AccessioniPrimary (citable) accession number: A7HVA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: September 7, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.