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A7HU87

- MTND_PARL1

UniProt

A7HU87 - MTND_PARL1

Protein

Acireductone dioxygenase

Gene

mtnD

Organism
Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.UniRule annotation

    Catalytic activityi

    1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 3-(methylthio)propanoate + formate + CO.UniRule annotation
    1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 4-(methylthio)-2-oxobutanoate + formate.UniRule annotation

    Cofactori

    Binds 1 iron ion per monomer.UniRule annotation
    Binds 1 nickel ion per monomer.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei96 – 961May play a role in metal incorporation in vivoUniRule annotation
    Metal bindingi97 – 971Iron; alternateUniRule annotation
    Metal bindingi97 – 971Nickel; alternateUniRule annotation
    Metal bindingi99 – 991Iron; alternateUniRule annotation
    Metal bindingi99 – 991Nickel; alternateUniRule annotation
    Sitei102 – 1021May play a role in transmitting local conformational changesUniRule annotation
    Metal bindingi103 – 1031Iron; alternateUniRule annotation
    Metal bindingi103 – 1031Nickel; alternateUniRule annotation
    Sitei105 – 1051Important to generate the dianionUniRule annotation
    Metal bindingi141 – 1411Iron; alternateUniRule annotation
    Metal bindingi141 – 1411Nickel; alternateUniRule annotation

    GO - Molecular functioni

    1. acireductone dioxygenase (Ni2+-requiring) activity Source: UniProtKB-HAMAP
    2. acireductone dioxygenase [iron(II)-requiring] activity Source: UniProtKB-HAMAP
    3. iron ion binding Source: UniProtKB-HAMAP
    4. nickel cation binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-methionine biosynthetic process from methylthioadenosine Source: UniProtKB-UniPathway
    2. L-methionine biosynthetic process from S-adenosylmethionine Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Methionine biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding, Nickel

    Enzyme and pathway databases

    BioCyciPLAV402881:GHQA-1879-MONOMER.
    UniPathwayiUPA00904; UER00878.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acireductone dioxygenaseUniRule annotation
    Alternative name(s):
    1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenaseUniRule annotation
    Short name:
    DHK-MTPene dioxygenaseUniRule annotation
    Acireductone dioxygenase (Fe(2+)-requiring)UniRule annotation (EC:1.13.11.54UniRule annotation)
    Short name:
    ARD'UniRule annotation
    Short name:
    Fe-ARDUniRule annotation
    Acireductone dioxygenase (Ni(2+)-requiring)UniRule annotation (EC:1.13.11.53UniRule annotation)
    Short name:
    ARDUniRule annotation
    Short name:
    Ni-ARDUniRule annotation
    Gene namesi
    Name:mtnDUniRule annotation
    Ordered Locus Names:Plav_1853
    OrganismiParvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
    Taxonomic identifieri402881 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhodobiaceaeParvibaculum
    ProteomesiUP000006377: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 184184Acireductone dioxygenasePRO_0000359214Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi402881.Plav_1853.

    Structurei

    3D structure databases

    ProteinModelPortaliA7HU87.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acireductone dioxygenase (ARD) family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1791.
    HOGENOMiHOG000201072.
    KOiK08967.
    OMAiVLCEKND.
    OrthoDBiEOG6ZPT06.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    HAMAPiMF_01682. Salvage_MtnD.
    InterProiIPR023956. Acireductn_d0ase.
    IPR004313. Acireductn_dOase_family.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR23418. PTHR23418. 1 hit.
    PfamiPF03079. ARD. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7HU87-1 [UniParc]FASTAAdd to Basket

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    MTHLTVYPDT DPATVLLDTR DGAEIAASLS GIGVVFERWD APHALGEDAD    50
    QTAVLAAYEA DVKRLMDEGG YKSVDVVRVK PDNPNRAEMR QKFLAEHTHD 100
    DDEVRFFVEG AGAFYLRKDG RVYRVVCERN DLISVPAGTT HWFDTGAAPH 150
    FCAIRIFTSP EGWVGHFTGD DIATRFPKFE SEPQ 184
    Length:184
    Mass (Da):20,487
    Last modified:September 11, 2007 - v1
    Checksum:iDDCA09AEF14BD9AD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000774 Genomic DNA. Translation: ABS63470.1.
    RefSeqiWP_012110763.1. NC_009719.1.
    YP_001413127.1. NC_009719.1.

    Genome annotation databases

    EnsemblBacteriaiABS63470; ABS63470; Plav_1853.
    GeneIDi5456069.
    KEGGipla:Plav_1853.
    PATRICi22865357. VBIParLav90819_1905.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000774 Genomic DNA. Translation: ABS63470.1 .
    RefSeqi WP_012110763.1. NC_009719.1.
    YP_001413127.1. NC_009719.1.

    3D structure databases

    ProteinModelPortali A7HU87.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 402881.Plav_1853.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS63470 ; ABS63470 ; Plav_1853 .
    GeneIDi 5456069.
    KEGGi pla:Plav_1853.
    PATRICi 22865357. VBIParLav90819_1905.

    Phylogenomic databases

    eggNOGi COG1791.
    HOGENOMi HOG000201072.
    KOi K08967.
    OMAi VLCEKND.
    OrthoDBi EOG6ZPT06.

    Enzyme and pathway databases

    UniPathwayi UPA00904 ; UER00878 .
    BioCyci PLAV402881:GHQA-1879-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    HAMAPi MF_01682. Salvage_MtnD.
    InterProi IPR023956. Acireductn_d0ase.
    IPR004313. Acireductn_dOase_family.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR23418. PTHR23418. 1 hit.
    Pfami PF03079. ARD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence and annotation of Parvibaculum lavamentivorans DS-1."
      Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.
      Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DS-1 / DSM 13023 / NCIMB 13966.

    Entry informationi

    Entry nameiMTND_PARL1
    AccessioniPrimary (citable) accession number: A7HU87
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 20, 2009
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3