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A7HU87

- MTND_PARL1

UniProt

A7HU87 - MTND_PARL1

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Protein

Acireductone dioxygenase

Gene
mtnD, Plav_1853
Organism
Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway By similarity.UniRule annotation

Catalytic activityi

1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 3-(methylthio)propanoate + formate + CO.UniRule annotation
1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 4-(methylthio)-2-oxobutanoate + formate.

Cofactori

Binds 1 iron ion per monomer By similarity.UniRule annotation
Binds 1 nickel ion per monomer By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei96 – 961May play a role in metal incorporation in vivo By similarity
Metal bindingi97 – 971Iron; alternate By similarity
Metal bindingi97 – 971Nickel; alternate By similarity
Metal bindingi99 – 991Iron; alternate By similarity
Metal bindingi99 – 991Nickel; alternate By similarity
Sitei102 – 1021May play a role in transmitting local conformational changes By similarity
Metal bindingi103 – 1031Iron; alternate By similarity
Metal bindingi103 – 1031Nickel; alternate By similarity
Sitei105 – 1051Important to generate the dianion By similarity
Metal bindingi141 – 1411Iron; alternate By similarity
Metal bindingi141 – 1411Nickel; alternate By similarity

GO - Molecular functioni

  1. acireductone dioxygenase (Ni2+-requiring) activity Source: UniProtKB-HAMAP
  2. acireductone dioxygenase [iron(II)-requiring] activity Source: UniProtKB-HAMAP
  3. iron ion binding Source: UniProtKB-HAMAP
  4. nickel cation binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-methionine biosynthetic process from S-adenosylmethionine Source: UniProtKB-HAMAP
  2. L-methionine salvage from methylthioadenosine Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Keywords - Ligandi

Iron, Metal-binding, Nickel

Enzyme and pathway databases

BioCyciPLAV402881:GHQA-1879-MONOMER.
UniPathwayiUPA00904; UER00878.

Names & Taxonomyi

Protein namesi
Recommended name:
Acireductone dioxygenase
Alternative name(s):
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Short name:
DHK-MTPene dioxygenase
Acireductone dioxygenase (Fe(2+)-requiring) (EC:1.13.11.54)
Short name:
ARD'
Short name:
Fe-ARD
Acireductone dioxygenase (Ni(2+)-requiring) (EC:1.13.11.53)
Short name:
ARD
Short name:
Ni-ARD
Gene namesi
Name:mtnD
Ordered Locus Names:Plav_1853
OrganismiParvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Taxonomic identifieri402881 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhodobiaceaeParvibaculum
ProteomesiUP000006377: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 184184Acireductone dioxygenaseUniRule annotationPRO_0000359214Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi402881.Plav_1853.

Structurei

3D structure databases

ProteinModelPortaliA7HU87.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1791.
HOGENOMiHOG000201072.
KOiK08967.
OMAiVLCEKND.
OrthoDBiEOG6ZPT06.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_01682. Salvage_MtnD.
InterProiIPR023956. Acireductn_d0ase.
IPR004313. Acireductn_dOase_family.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR23418. PTHR23418. 1 hit.
PfamiPF03079. ARD. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

A7HU87-1 [UniParc]FASTAAdd to Basket

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MTHLTVYPDT DPATVLLDTR DGAEIAASLS GIGVVFERWD APHALGEDAD    50
QTAVLAAYEA DVKRLMDEGG YKSVDVVRVK PDNPNRAEMR QKFLAEHTHD 100
DDEVRFFVEG AGAFYLRKDG RVYRVVCERN DLISVPAGTT HWFDTGAAPH 150
FCAIRIFTSP EGWVGHFTGD DIATRFPKFE SEPQ 184
Length:184
Mass (Da):20,487
Last modified:September 11, 2007 - v1
Checksum:iDDCA09AEF14BD9AD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000774 Genomic DNA. Translation: ABS63470.1.
RefSeqiWP_012110763.1. NC_009719.1.
YP_001413127.1. NC_009719.1.

Genome annotation databases

EnsemblBacteriaiABS63470; ABS63470; Plav_1853.
GeneIDi5456069.
KEGGipla:Plav_1853.
PATRICi22865357. VBIParLav90819_1905.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000774 Genomic DNA. Translation: ABS63470.1 .
RefSeqi WP_012110763.1. NC_009719.1.
YP_001413127.1. NC_009719.1.

3D structure databases

ProteinModelPortali A7HU87.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 402881.Plav_1853.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS63470 ; ABS63470 ; Plav_1853 .
GeneIDi 5456069.
KEGGi pla:Plav_1853.
PATRICi 22865357. VBIParLav90819_1905.

Phylogenomic databases

eggNOGi COG1791.
HOGENOMi HOG000201072.
KOi K08967.
OMAi VLCEKND.
OrthoDBi EOG6ZPT06.

Enzyme and pathway databases

UniPathwayi UPA00904 ; UER00878 .
BioCyci PLAV402881:GHQA-1879-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
HAMAPi MF_01682. Salvage_MtnD.
InterProi IPR023956. Acireductn_d0ase.
IPR004313. Acireductn_dOase_family.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR23418. PTHR23418. 1 hit.
Pfami PF03079. ARD. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence and annotation of Parvibaculum lavamentivorans DS-1."
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DS-1 / DSM 13023 / NCIMB 13966.

Entry informationi

Entry nameiMTND_PARL1
AccessioniPrimary (citable) accession number: A7HU87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: September 11, 2007
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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