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Protein

Catalase-peroxidase

Gene

katG

Organism
Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei92 – 921Transition state stabilizerUniRule annotation
Active sitei96 – 961Proton acceptorUniRule annotation
Metal bindingi264 – 2641Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciPLAV402881:GHQA-1526-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Plav_1508
OrganismiParvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Taxonomic identifieri402881 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhodobiaceaeParvibaculum
Proteomesi
  • UP000006377 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 721721Catalase-peroxidasePRO_0000354854Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki95 ↔ 223Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-249)UniRule annotation
Cross-linki223 ↔ 249Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-95)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiA7HT94.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi402881.Plav_1508.

Structurei

3D structure databases

ProteinModelPortaliA7HT94.
SMRiA7HT94. Positions 22-719.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7HT94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTSTSGKCP VMHGSMTTAE RSVTEWWPNA LNLDILHQHD TKPNPMGKDF
60 70 80 90 100
DYREELKKLD VAALKKDLQA LMTDSQDWWP ADWGHYGGLM IRMAWHSAGS
110 120 130 140 150
YRLFDGRGGG GTGNQRFAPL NSWPDNGNLD KARRLLWPIK KKYGNKLSWA
160 170 180 190 200
DLYILAGNVA YESMGLKTFG FAFGREDIWH PEKDVYWGSE KEWLAESVLR
210 220 230 240 250
YANEEDPESL EAPLGAVHMG LIYVNPQGRD GKPDPLKSAH DVRVTFKRMA
260 270 280 290 300
MNDEETAALT AGGHTVGKAH GNGLESNLSA PPEAADIEEQ GFGWVNHKTR
310 320 330 340 350
GVGRDTVTSG LEGAWTSKPT TFDMGYFDML FGHEWELKKS PAGAWQWQPI
360 370 380 390 400
DIKEEDMPVD VEDPSIRRMP IMTDADMAMK VDPIYREICE RFRKDPEYFK
410 420 430 440 450
DTFARAWFKL THRDMGPKVR YVGPEVPAED LIWQDPIPAG NTSYDVGAVK
460 470 480 490 500
AKIAASGLSV SELVSTAWDS ARTYRGSDMR GGANGARIRL APQKDWVGNE
510 520 530 540 550
PERLKKVLSM LEPIAKATGA SLADVIVLAG NVGVEQAAKA AGFDIAVPFA
560 570 580 590 600
PGRGDASAEQ TDAESFEALE PLADAYRNFL KRDYELPPEE LMLDRTQLMG
610 620 630 640 650
LTGPEMTVLV GGMRVMGTNH GGTRHGVFTD REGALTNDFF VNLTDMGNSW
660 670 680 690 700
VKNGGHYDVR DRKTGKTKWT ATRVDLVFGS NSILRAYSEV YAQDDAKEKF
710 720
VKDFVAAWTK VMNADRFDLK K
Length:721
Mass (Da):80,298
Last modified:September 11, 2007 - v1
Checksum:i15AFA66AD7B670A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000774 Genomic DNA. Translation: ABS63127.1.
RefSeqiWP_012110413.1. NC_009719.1.

Genome annotation databases

EnsemblBacteriaiABS63127; ABS63127; Plav_1508.
KEGGipla:Plav_1508.
PATRICi22864638. VBIParLav90819_1554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000774 Genomic DNA. Translation: ABS63127.1.
RefSeqiWP_012110413.1. NC_009719.1.

3D structure databases

ProteinModelPortaliA7HT94.
SMRiA7HT94. Positions 22-719.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi402881.Plav_1508.

Proteomic databases

PRIDEiA7HT94.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS63127; ABS63127; Plav_1508.
KEGGipla:Plav_1508.
PATRICi22864638. VBIParLav90819_1554.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Enzyme and pathway databases

BioCyciPLAV402881:GHQA-1526-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_PARL1
AccessioniPrimary (citable) accession number: A7HT94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: September 11, 2007
Last modified: September 7, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.