A7HT94 (KATG_PARL1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Catalase-peroxidase
Short name=CP
EC=1.11.1.21

Alternative name(s):
Peroxidase/catalase

Gene names

Name:	katG
Ordered Locus Names:	Plav_1508

Organism

Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966) [Complete proteome] [HAMAP]

Taxonomic identifier

402881 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Parvibaculum

Protein attributes

Sequence length	721 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity By similarity. HAMAP MF_01961
Catalytic activity	Donor + H2O2 = oxidized donor + 2 H2O. HAMAP MF_01961 2 H2O2 = O2 + 2 H2O. HAMAP MF_01961
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per dimer By similarity.
Subunit structure	Homodimer or homotetramer By similarity. HAMAP MF_01961
Post-translational modification	The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme By similarity. HAMAP MF_01961
Sequence similarities	Belongs to the peroxidase family. Peroxidase/catalase subfamily.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	catalase activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 721	721	Catalase-peroxidase HAMAP MF_01961		PRO_0000354854
Sites
	Active site	96	1	Proton acceptor By similarity
	Metal binding	264	1	Iron (heme axial ligand) By similarity
	Site	92	1	Transition state stabilizer By similarity
Amino acid modifications
	Cross-link	95 ↔ 223		Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-249) By similarity
	Cross-link	223 ↔ 249		Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-95) By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7HT94 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 15AFA66AD7B670A1	FASTA	721	80,298
	10 20 30 40 50 60 MNTSTSGKCP VMHGSMTTAE RSVTEWWPNA LNLDILHQHD TKPNPMGKDF DYREELKKLD 70 80 90 100 110 120 VAALKKDLQA LMTDSQDWWP ADWGHYGGLM IRMAWHSAGS YRLFDGRGGG GTGNQRFAPL 130 140 150 160 170 180 NSWPDNGNLD KARRLLWPIK KKYGNKLSWA DLYILAGNVA YESMGLKTFG FAFGREDIWH 190 200 210 220 230 240 PEKDVYWGSE KEWLAESVLR YANEEDPESL EAPLGAVHMG LIYVNPQGRD GKPDPLKSAH 250 260 270 280 290 300 DVRVTFKRMA MNDEETAALT AGGHTVGKAH GNGLESNLSA PPEAADIEEQ GFGWVNHKTR 310 320 330 340 350 360 GVGRDTVTSG LEGAWTSKPT TFDMGYFDML FGHEWELKKS PAGAWQWQPI DIKEEDMPVD 370 380 390 400 410 420 VEDPSIRRMP IMTDADMAMK VDPIYREICE RFRKDPEYFK DTFARAWFKL THRDMGPKVR 430 440 450 460 470 480 YVGPEVPAED LIWQDPIPAG NTSYDVGAVK AKIAASGLSV SELVSTAWDS ARTYRGSDMR 490 500 510 520 530 540 GGANGARIRL APQKDWVGNE PERLKKVLSM LEPIAKATGA SLADVIVLAG NVGVEQAAKA 550 560 570 580 590 600 AGFDIAVPFA PGRGDASAEQ TDAESFEALE PLADAYRNFL KRDYELPPEE LMLDRTQLMG 610 620 630 640 650 660 LTGPEMTVLV GGMRVMGTNH GGTRHGVFTD REGALTNDFF VNLTDMGNSW VKNGGHYDVR 670 680 690 700 710 720 DRKTGKTKWT ATRVDLVFGS NSILRAYSEV YAQDDAKEKF VKDFVAAWTK VMNADRFDLK K

References

[1]

"Complete genome sequence and annotation of Parvibaculum lavamentivorans DS-1." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DS-1 / DSM 13023 / NCIMB 13966.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000774 Genomic DNA. Translation: ABS63127.1.
RefSeq	YP_001412784.1. NC_009719.1.
3D structure databases
ProteinModelPortal	A7HT94.
SMR	A7HT94. Positions 22-719.
ModBase	Search...
Protein-protein interaction databases
STRING	A7HT94.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5453652.
GenomeReviews	Gene locus Plav_1508 in contig CP000774_GR.
KEGG	pla:Plav_1508.
PATRIC	22864638. VBIParLav90819_1554.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0376.
HOGENOM	HBG285610.
OMA	WPNALNL.
ProtClustDB	PRK15061.
Family and domain databases
HAMAP	MF_01961. Catal-peroxid. [Tree]
InterPro	IPR000763. Catalase_peroxidase. IPR010255. Haem_peroxidase. IPR002016. Haem_peroxidase_pln/fun/bac. IPR019794. Peroxidases_AS. [Graphical view]
KO	K03782.
Pfam	PF00141. peroxidase. 2 hits. [Graphical view]
PRINTS	PR00460. BPEROXIDASE. PR00458. PEROXIDASE.
SUPFAM	SSF48113. Peroxidase_super. 2 hits.
TIGRFAMs	TIGR00198. Cat_per_HPI. 1 hit.
PROSITE	PS00435. PEROXIDASE_1. False negative. PS00436. PEROXIDASE_2. 1 hit. PS50873. PEROXIDASE_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KATG_PARL1

Accession

Primary (citable) accession number: A7HT94

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2008
Last sequence update:	September 11, 2007
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program