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Protein

RNA pyrophosphohydrolase

Gene

rppH

Organism
Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.UniRule annotationSAAS annotation

Cofactori

a divalent metal cationUniRule annotationSAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotationImported

Keywords - Ligandi

Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pyrophosphohydrolaseUniRule annotationSAAS annotation (EC:3.6.1.-UniRule annotation)
Alternative name(s):
(Di)nucleoside polyphosphate hydrolaseUniRule annotation
Gene namesi
Name:rppHUniRule annotation
Synonyms:nudHUniRule annotation
Ordered Locus Names:Plav_1470Imported
OrganismiParvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)Imported
Taxonomic identifieri402881 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhodobiaceaeParvibaculum
Proteomesi
  • UP000006377 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi402881.Plav_1470.

Structurei

3D structure databases

ProteinModelPortaliA7HT57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 164Nudix hydrolaseInterPro annotationAdd BLAST148

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi55 – 76Nudix boxUniRule annotationAdd BLAST22

Sequence similaritiesi

Belongs to the Nudix hydrolase family. RppH subfamily.UniRule annotationSAAS annotation
Contains 1 nudix hydrolase domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EJF. Bacteria.
COG0494. LUCA.
HOGENOMiHOG000066722.
KOiK08311.
OMAiQNAWQFP.
OrthoDBiPOG091H0392.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
HAMAPiMF_00298. Nudix_RppH. 1 hit.
InterProiIPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7HT57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRHSDKKEP VAPETLPYRP CVGIMLINRE GLVWVGNRIQ EVDTGSTLTW
60 70 80 90 100
QMPQGGIDEG ESPEEAARRE LMEETGTDKA QIVGETKDWL TYELPPHLVG
110 120 130 140 150
IALKGKYRGQ KQKWFAMRFT GEDSDIDIAA DDHQEFSEWT WVPIEELLEL
160 170
IVPFKRSVYE RLVREFAPFA VPQEG
Length:175
Mass (Da):20,056
Last modified:September 11, 2007 - v1
Checksum:iE025289E90F2D902
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000774 Genomic DNA. Translation: ABS63090.1.
RefSeqiWP_012110371.1. NC_009719.1.

Genome annotation databases

EnsemblBacteriaiABS63090; ABS63090; Plav_1470.
KEGGipla:Plav_1470.
PATRICi22864558. VBIParLav90819_1515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000774 Genomic DNA. Translation: ABS63090.1.
RefSeqiWP_012110371.1. NC_009719.1.

3D structure databases

ProteinModelPortaliA7HT57.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi402881.Plav_1470.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS63090; ABS63090; Plav_1470.
KEGGipla:Plav_1470.
PATRICi22864558. VBIParLav90819_1515.

Phylogenomic databases

eggNOGiENOG4105EJF. Bacteria.
COG0494. LUCA.
HOGENOMiHOG000066722.
KOiK08311.
OMAiQNAWQFP.
OrthoDBiPOG091H0392.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
HAMAPiMF_00298. Nudix_RppH. 1 hit.
InterProiIPR020476. Nudix_hydrolase.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR022927. RppH.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA7HT57_PARL1
AccessioniPrimary (citable) accession number: A7HT57
Entry historyi
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 30, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.