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Protein

RNA pyrophosphohydrolase

Gene

rppH

Organism
Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.UniRule annotationSAAS annotation

Cofactori

a divalent metal cationUniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

BioCyciPLAV402881:G1G9L-1494-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pyrophosphohydrolaseUniRule annotationSAAS annotation (EC:3.6.1.-UniRule annotation)
Alternative name(s):
(Di)nucleoside polyphosphate hydrolaseUniRule annotation
Gene namesi
Name:rppHUniRule annotation
Synonyms:nudHUniRule annotation
Ordered Locus Names:Plav_1470Imported
OrganismiParvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)Imported
Taxonomic identifieri402881 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhodobiaceaeParvibaculum
Proteomesi
  • UP000006377 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi402881.Plav_1470

Structurei

3D structure databases

ProteinModelPortaliA7HT57
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 164Nudix hydrolaseInterPro annotationAdd BLAST148

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi55 – 76Nudix boxUniRule annotationAdd BLAST22

Sequence similaritiesi

Belongs to the Nudix hydrolase family. RppH subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105EJF Bacteria
COG0494 LUCA
HOGENOMiHOG000066722
KOiK08311
OMAiRPCVGIM
OrthoDBiPOG091H0392

Family and domain databases

CDDicd03671 Ap4A_hydrolase_plant_like, 1 hit
HAMAPiMF_00298 Nudix_RppH, 1 hit
InterProiView protein in InterPro
IPR020476 Nudix_hydrolase
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR020084 NUDIX_hydrolase_CS
IPR000086 NUDIX_hydrolase_dom
IPR022927 RppH
PfamiView protein in Pfam
PF00293 NUDIX, 1 hit
PRINTSiPR00502 NUDIXFAMILY
SUPFAMiSSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit
PS00893 NUDIX_BOX, 1 hit

Sequencei

Sequence statusi: Complete.

A7HT57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRHSDKKEP VAPETLPYRP CVGIMLINRE GLVWVGNRIQ EVDTGSTLTW
60 70 80 90 100
QMPQGGIDEG ESPEEAARRE LMEETGTDKA QIVGETKDWL TYELPPHLVG
110 120 130 140 150
IALKGKYRGQ KQKWFAMRFT GEDSDIDIAA DDHQEFSEWT WVPIEELLEL
160 170
IVPFKRSVYE RLVREFAPFA VPQEG
Length:175
Mass (Da):20,056
Last modified:September 11, 2007 - v1
Checksum:iE025289E90F2D902
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000774 Genomic DNA Translation: ABS63090.1
RefSeqiWP_012110371.1, NC_009719.1

Genome annotation databases

EnsemblBacteriaiABS63090; ABS63090; Plav_1470
KEGGipla:Plav_1470

Similar proteinsi

Entry informationi

Entry nameiA7HT57_PARL1
AccessioniPrimary (citable) accession number: A7HT57
Entry historyiIntegrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health