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Protein

Malate dehydrogenase

Gene

mdh

Organism
Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NAD1
Binding sitei83Substrate1
Binding sitei89Substrate1
Binding sitei96NAD1
Binding sitei121Substrate1
Binding sitei152Substrate1
Active sitei176Proton acceptor1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NAD6
Nucleotide bindingi119 – 121NAD3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:Plav_1450
OrganismiParvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Taxonomic identifieri402881 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhodobiaceaeParvibaculum
Proteomesi
  • UP000006377 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000724191 – 333Malate dehydrogenaseAdd BLAST333

Interactioni

Protein-protein interaction databases

STRINGi402881.Plav_1450.

Structurei

3D structure databases

ProteinModelPortaliA7HT37.
SMRiA7HT37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000213794.
KOiK00024.
OMAiMDLMQTA.
OrthoDBiPOG091H02N6.

Family and domain databases

CDDicd01339. LDH-like_MDH. 1 hit.
Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

A7HT37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARKKIALIG GGQIGGTLAL LAGLKELGDV VIFDIAEGLP QGKALDLAQT
60 70 80 90 100
GPVEGYNTAL SGANDYKGIK GADVVIVTAG VPRKPGMSRD DLLGINLKVM
110 120 130 140 150
KQVGEGIAKY APNAFVVCIT NPLDAMVWAL RQFSGLPHNK VVGMAGVLDS
160 170 180 190 200
GRFRLFLAEE FGVSVEDVTA FVLGGHGDTM VPLPRYSTVA GIPLPDLVKM
210 220 230 240 250
GWTTKEKLDK IIQRTRDGGA EIVGLLKTGS AFYAPAASGI QMAEAYLKDQ
260 270 280 290 300
KRVLPCAAYI NGQYGVKDMY VGVPVVIGAG GVERIVEIDL NGSEKKQFMN
310 320 330
SVNAVKGLVD ACKKIDPAVA KGAAPAKKAA KKK
Length:333
Mass (Da):34,921
Last modified:September 11, 2007 - v1
Checksum:i518692C324191DB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000774 Genomic DNA. Translation: ABS63070.1.
RefSeqiWP_012110350.1. NC_009719.1.

Genome annotation databases

EnsemblBacteriaiABS63070; ABS63070; Plav_1450.
KEGGipla:Plav_1450.

Similar proteinsi

Entry informationi

Entry nameiMDH_PARL1
AccessioniPrimary (citable) accession number: A7HT37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 11, 2007
Last modified: October 25, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families