A7HSR8 (ACSA_PARL1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase
EC=6.2.1.1

Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme

Gene names

Name:	acsA
Ordered Locus Names:	Plav_1331

Organism

Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966) [Complete proteome] [HAMAP]

Taxonomic identifier

402881 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Parvibaculum

Protein attributes

Sequence length	647 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 647	647	Acetyl-coenzyme A synthetase HAMAP MF_01123		PRO_1000073044
Sites
	Active site	514	1	By similarity
Amino acid modifications
	Modified residue	606	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7HSR8 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 43419A3302E5FBE3	FASTA	647	71,661
	10 20 30 40 50 60 MSDEIFPVPA EWKKRAIVDA EKYRHMYEAS INDPESFWRR EGLRIDWMKP YTKIKDTSFD 70 80 90 100 110 120 PHNVSIKWFE DGTLNASVNC IDRHLERRAG QVAIIWEGDD PSIDRKITYR ELHDEVCRFA 130 140 150 160 170 180 NVLKARGVKK GDRVTIYMPM IPEAAYAMLA CARIGAVHSV VFGGFSPDSL AGRIVDCASS 190 200 210 220 230 240 CVITADEGVR GGRKIPLKAN TDEALKKCPG VKSVIVVKHT GGAVAMEKGR DVWYAEEAAK 250 260 270 280 290 300 VSATCAPEEM NAEDPLFILY TSGSTGKPKG VLHTTGGYMV YASMTHQYVF DYHDGDIYWC 310 320 330 340 350 360 TADVGWVTGH SYILYGPLAN GATTLMFEGV PNYPDASRCW QVIDKHEVNI FYTAPTALRA 370 380 390 400 410 420 LMREGEEPVK KTSRKSLRLL GSVGEPINPE AWLWYHRVVG DGRCPIVDTW WQTETGGILI 430 440 450 460 470 480 SPLPGAIATK PGSATKPFFG VQPVIVDAEG NVQEGATTGN LCIDDSWPGQ MRTVYGDHQR 490 500 510 520 530 540 FVETYFIQYP GRYFTGDGCR RDEDGYYWIT GRVDDVLNVS GHRMGTAEVE SALVAHPKVA 550 560 570 580 590 600 EAAVVGYPHD IKGQGIYAYV TLIAGEAATE ELRKELVTWV RKEIGPIASP DLIQFAPGLP 610 620 630 640 KTRSGKIMRR ILRKIAEDDF SNLGDTSTLA DPSVVTDLVD NRQNKAG

References

[1]

"Complete genome sequence and annotation of Parvibaculum lavamentivorans DS-1." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DS-1 / DSM 13023 / NCIMB 13966.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000774 Genomic DNA. Translation: ABS62951.1.
RefSeq	YP_001412608.1. NC_009719.1.
3D structure databases
ProteinModelPortal	A7HSR8.
SMR	A7HSR8. Positions 8-643.
ModBase	Search...
Protein-protein interaction databases
STRING	A7HSR8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5454434.
GenomeReviews	Gene locus Plav_1331 in contig CP000774_GR.
KEGG	pla:Plav_1331.
PATRIC	22864268. VBIParLav90819_1372.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0365.
HOGENOM	HBG547964.
OMA	GVEHEVS.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACSA_PARL1

Accession

Primary (citable) accession number: A7HSR8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	September 11, 2007
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program