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A7HSL7 (SYL_PARL1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:Plav_1280
OrganismParvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966) [Complete proteome] [HAMAP]
Taxonomic identifier402881 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhodobiaceaeParvibaculum

Protein attributes

Sequence length870 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 870870Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000334788

Regions

Motif43 – 5311"HIGH" region HAMAP-Rule MF_00049
Motif630 – 6345"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6331ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A7HSL7 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 45E0A439AAE78404

FASTA87097,257
        10         20         30         40         50         60 
MSTRYNARAA EPKWQKIWEE RGDFLMRDDA DGKPKYYVLE MFPYPSGRIH MGHVRNYTMG 

        70         80         90        100        110        120 
DVIARYKKAR GFNVLHPMGW DAFGMPAENA AMEKNVHPKG WTYDNIAAMR EQLKAIGLAI 

       130        140        150        160        170        180 
DWSREFATCD PEYYGHEQAL FLDMLEAGLV SRKKSMVNWD PVDNTVLANE QVIDGRGWRS 

       190        200        210        220        230        240 
GALVERRELT QWFLKISDFA DELLEGLDTL DRWPEKVRLM QKNWIGRSEG ARVFFELENA 

       250        260        270        280        290        300 
PDGNTKLEIF TTRPDTLYGA SFCALSPHHP LTQSLAKDNP ALTDFIRECD RIGTSEEAIE 

       310        320        330        340        350        360 
TADKMGFDTG LKARHPFIEG KTLPVYVANF VLMDYGTGAI FACPAHDQRD LDFARKYNLP 

       370        380        390        400        410        420 
VIPVVAPKDK QGAELDAFAS GLAETGTDAY TGDGVAINSD FLNGLDVQSA KRAAIDRLEA 

       430        440        450        460        470        480 
KGIGEGTVNY RLRDWGISRQ RYWGCPIPVI HCASCGTLPV PRDQLPVVLP DDVNFSEPGN 

       490        500        510        520        530        540 
PLDRHPSWKH VDCPKCGKPA SRETDTFDTF VDSSWYFVRF TAPDAPTPTD KALADHWLPV 

       550        560        570        580        590        600 
DQYIGGIEHA ILHLLYSRFF TRAMKATGHV SLDEPFAGLF TQGMVNHETY RDAEGRWVPP 

       610        620        630        640        650        660 
AEVDIETVSG KRVAKRIADG EPVIIGSVEK MSKSKKNTVD PEDIIAKYGA DTARWFMLSD 

       670        680        690        700        710        720 
SPPERDVQWT DQGAEGAWRF TQRLWRMVTE RQEDLAPTGT PMPTAFSEDE LTLRRAAHQA 

       730        740        750        760        770        780 
LAAATEDFEN LRFNRAVARV YELANAVSGF TPGTPEGAFA KREALEILVQ IVGPMMPHIA 

       790        800        810        820        830        840 
EECWEALGHG EPLTAAEWPV ADKALLVEDS VTIAVQVNGK RRDELTIARD ADRETVERAA 

       850        860        870 
LALEKVGKAI DGKPVRKVIV VPGKIVNIVV 

« Hide

References

[1]"Complete genome sequence and annotation of Parvibaculum lavamentivorans DS-1."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DS-1 / DSM 13023 / NCIMB 13966.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000774 Genomic DNA. Translation: ABS62900.1.
RefSeqYP_001412557.1. NC_009719.1.

3D structure databases

ProteinModelPortalA7HSL7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING402881.Plav_1280.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS62900; ABS62900; Plav_1280.
GeneID5456455.
KEGGpla:Plav_1280.
PATRIC22864158. VBIParLav90819_1318.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAREKNDWE.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycPLAV402881:GHQA-1294-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_PARL1
AccessionPrimary (citable) accession number: A7HSL7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: April 16, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries