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A7HSL7

- SYL_PARL1

UniProt

A7HSL7 - SYL_PARL1

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Protein

Leucine--tRNA ligase

Gene
leuS, Plav_1280
Organism
Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei633 – 6331ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPLAV402881:GHQA-1294-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Plav_1280
OrganismiParvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Taxonomic identifieri402881 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhodobiaceaeParvibaculum
ProteomesiUP000006377: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 870870Leucine--tRNA ligaseUniRule annotationPRO_0000334788Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi402881.Plav_1280.

Structurei

3D structure databases

ProteinModelPortaliA7HSL7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionUniRule annotationAdd
BLAST
Motifi630 – 6345"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiKGNPLES.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7HSL7-1 [UniParc]FASTAAdd to Basket

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MSTRYNARAA EPKWQKIWEE RGDFLMRDDA DGKPKYYVLE MFPYPSGRIH    50
MGHVRNYTMG DVIARYKKAR GFNVLHPMGW DAFGMPAENA AMEKNVHPKG 100
WTYDNIAAMR EQLKAIGLAI DWSREFATCD PEYYGHEQAL FLDMLEAGLV 150
SRKKSMVNWD PVDNTVLANE QVIDGRGWRS GALVERRELT QWFLKISDFA 200
DELLEGLDTL DRWPEKVRLM QKNWIGRSEG ARVFFELENA PDGNTKLEIF 250
TTRPDTLYGA SFCALSPHHP LTQSLAKDNP ALTDFIRECD RIGTSEEAIE 300
TADKMGFDTG LKARHPFIEG KTLPVYVANF VLMDYGTGAI FACPAHDQRD 350
LDFARKYNLP VIPVVAPKDK QGAELDAFAS GLAETGTDAY TGDGVAINSD 400
FLNGLDVQSA KRAAIDRLEA KGIGEGTVNY RLRDWGISRQ RYWGCPIPVI 450
HCASCGTLPV PRDQLPVVLP DDVNFSEPGN PLDRHPSWKH VDCPKCGKPA 500
SRETDTFDTF VDSSWYFVRF TAPDAPTPTD KALADHWLPV DQYIGGIEHA 550
ILHLLYSRFF TRAMKATGHV SLDEPFAGLF TQGMVNHETY RDAEGRWVPP 600
AEVDIETVSG KRVAKRIADG EPVIIGSVEK MSKSKKNTVD PEDIIAKYGA 650
DTARWFMLSD SPPERDVQWT DQGAEGAWRF TQRLWRMVTE RQEDLAPTGT 700
PMPTAFSEDE LTLRRAAHQA LAAATEDFEN LRFNRAVARV YELANAVSGF 750
TPGTPEGAFA KREALEILVQ IVGPMMPHIA EECWEALGHG EPLTAAEWPV 800
ADKALLVEDS VTIAVQVNGK RRDELTIARD ADRETVERAA LALEKVGKAI 850
DGKPVRKVIV VPGKIVNIVV 870
Length:870
Mass (Da):97,257
Last modified:September 11, 2007 - v1
Checksum:i45E0A439AAE78404
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000774 Genomic DNA. Translation: ABS62900.1.
RefSeqiYP_001412557.1. NC_009719.1.

Genome annotation databases

EnsemblBacteriaiABS62900; ABS62900; Plav_1280.
GeneIDi5456455.
KEGGipla:Plav_1280.
PATRICi22864158. VBIParLav90819_1318.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000774 Genomic DNA. Translation: ABS62900.1 .
RefSeqi YP_001412557.1. NC_009719.1.

3D structure databases

ProteinModelPortali A7HSL7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 402881.Plav_1280.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS62900 ; ABS62900 ; Plav_1280 .
GeneIDi 5456455.
KEGGi pla:Plav_1280.
PATRICi 22864158. VBIParLav90819_1318.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi KGNPLES.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PLAV402881:GHQA-1294-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence and annotation of Parvibaculum lavamentivorans DS-1."
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DS-1 / DSM 13023 / NCIMB 13966.

Entry informationi

Entry nameiSYL_PARL1
AccessioniPrimary (citable) accession number: A7HSL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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