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A7HSG7

- HIS2_PARL1

UniProt

A7HSG7 - HIS2_PARL1

Protein

Phosphoribosyl-ATP pyrophosphatase

Gene

hisE

Organism
Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-AMP + diphosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosyl-ATP diphosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPLAV402881:GHQA-1244-MONOMER.
    UniPathwayiUPA00031; UER00007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosyl-ATP pyrophosphataseUniRule annotation (EC:3.6.1.31UniRule annotation)
    Short name:
    PRA-PHUniRule annotation
    Gene namesi
    Name:hisEUniRule annotation
    Ordered Locus Names:Plav_1230
    OrganismiParvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
    Taxonomic identifieri402881 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhodobiaceaeParvibaculum
    ProteomesiUP000006377: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 109109Phosphoribosyl-ATP pyrophosphatasePRO_0000319657Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi402881.Plav_1230.

    Structurei

    3D structure databases

    ProteinModelPortaliA7HSG7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PRA-PH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0140.
    HOGENOMiHOG000220965.
    KOiK01523.
    OMAiPEKCAEK.
    OrthoDBiEOG6CGCMH.

    Family and domain databases

    HAMAPiMF_01020. HisE.
    InterProiIPR008179. PRib-ATP_PPHydrolase.
    IPR021130. PRib-ATP_PPHydrolase-like.
    [Graphical view]
    PfamiPF01503. PRA-PH. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03188. histidine_hisI. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7HSG7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAADASQLDR LFEVIAARKG ADAGSSYTAK LLAKGVPACA QKLGEEAVET    50
    VIAAVSGDGG GVVSESADLL YHWLVLMAAS NTDPADVYAE LERREGRSGL 100
    TEKAARGER 109
    Length:109
    Mass (Da):11,324
    Last modified:September 11, 2007 - v1
    Checksum:i672A22B94D104A93
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000774 Genomic DNA. Translation: ABS62850.1.
    RefSeqiYP_001412507.1. NC_009719.1.

    Genome annotation databases

    EnsemblBacteriaiABS62850; ABS62850; Plav_1230.
    GeneIDi5455010.
    KEGGipla:Plav_1230.
    PATRICi22864056. VBIParLav90819_1267.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000774 Genomic DNA. Translation: ABS62850.1 .
    RefSeqi YP_001412507.1. NC_009719.1.

    3D structure databases

    ProteinModelPortali A7HSG7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 402881.Plav_1230.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS62850 ; ABS62850 ; Plav_1230 .
    GeneIDi 5455010.
    KEGGi pla:Plav_1230.
    PATRICi 22864056. VBIParLav90819_1267.

    Phylogenomic databases

    eggNOGi COG0140.
    HOGENOMi HOG000220965.
    KOi K01523.
    OMAi PEKCAEK.
    OrthoDBi EOG6CGCMH.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00007 .
    BioCyci PLAV402881:GHQA-1244-MONOMER.

    Family and domain databases

    HAMAPi MF_01020. HisE.
    InterProi IPR008179. PRib-ATP_PPHydrolase.
    IPR021130. PRib-ATP_PPHydrolase-like.
    [Graphical view ]
    Pfami PF01503. PRA-PH. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03188. histidine_hisI. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence and annotation of Parvibaculum lavamentivorans DS-1."
      Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.
      Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DS-1 / DSM 13023 / NCIMB 13966.

    Entry informationi

    Entry nameiHIS2_PARL1
    AccessioniPrimary (citable) accession number: A7HSG7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3