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Protein

Phosphoribosyl-ATP pyrophosphatase

Gene

hisE

Organism
Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-AMP + diphosphate.UniRule annotation

Pathway: L-histidine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (Plav_0600)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPLAV402881:GHQA-1244-MONOMER.
UniPathwayiUPA00031; UER00007.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosyl-ATP pyrophosphataseUniRule annotation (EC:3.6.1.31UniRule annotation)
Short name:
PRA-PHUniRule annotation
Gene namesi
Name:hisEUniRule annotation
Ordered Locus Names:Plav_1230
OrganismiParvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Taxonomic identifieri402881 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhodobiaceaeParvibaculum
ProteomesiUP000006377 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 109109Phosphoribosyl-ATP pyrophosphatasePRO_0000319657Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi402881.Plav_1230.

Structurei

3D structure databases

ProteinModelPortaliA7HSG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PRA-PH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0140.
HOGENOMiHOG000220965.
KOiK01523.
OMAiLWFHSMV.
OrthoDBiEOG6CGCMH.

Family and domain databases

HAMAPiMF_01020. HisE.
InterProiIPR008179. PRib-ATP_PPHydrolase.
IPR021130. PRib-ATP_PPHydrolase-like.
[Graphical view]
PfamiPF01503. PRA-PH. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03188. histidine_hisI. 1 hit.

Sequencei

Sequence statusi: Complete.

A7HSG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAADASQLDR LFEVIAARKG ADAGSSYTAK LLAKGVPACA QKLGEEAVET
60 70 80 90 100
VIAAVSGDGG GVVSESADLL YHWLVLMAAS NTDPADVYAE LERREGRSGL

TEKAARGER
Length:109
Mass (Da):11,324
Last modified:September 11, 2007 - v1
Checksum:i672A22B94D104A93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000774 Genomic DNA. Translation: ABS62850.1.
RefSeqiWP_012110118.1. NC_009719.1.
YP_001412507.1. NC_009719.1.

Genome annotation databases

EnsemblBacteriaiABS62850; ABS62850; Plav_1230.
KEGGipla:Plav_1230.
PATRICi22864056. VBIParLav90819_1267.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000774 Genomic DNA. Translation: ABS62850.1.
RefSeqiWP_012110118.1. NC_009719.1.
YP_001412507.1. NC_009719.1.

3D structure databases

ProteinModelPortaliA7HSG7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi402881.Plav_1230.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS62850; ABS62850; Plav_1230.
KEGGipla:Plav_1230.
PATRICi22864056. VBIParLav90819_1267.

Phylogenomic databases

eggNOGiCOG0140.
HOGENOMiHOG000220965.
KOiK01523.
OMAiLWFHSMV.
OrthoDBiEOG6CGCMH.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00007.
BioCyciPLAV402881:GHQA-1244-MONOMER.

Family and domain databases

HAMAPiMF_01020. HisE.
InterProiIPR008179. PRib-ATP_PPHydrolase.
IPR021130. PRib-ATP_PPHydrolase-like.
[Graphical view]
PfamiPF01503. PRA-PH. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03188. histidine_hisI. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence and annotation of Parvibaculum lavamentivorans DS-1."
    Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DS-1 / DSM 13023 / NCIMB 13966.

Entry informationi

Entry nameiHIS2_PARL1
AccessioniPrimary (citable) accession number: A7HSG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 11, 2007
Last modified: April 1, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.