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Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei245ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPLAV402881:G1G9L-1126-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Ordered Locus Names:Plav_1104
OrganismiParvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Taxonomic identifieri402881 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhodobiaceaeParvibaculum
Proteomesi
  • UP000006377 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003677301 – 449Glutamate--tRNA ligase 1Add BLAST449

Proteomic databases

PRIDEiA7HS42

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi402881.Plav_1104

Structurei

3D structure databases

ProteinModelPortaliA7HS42
SMRiA7HS42
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 21"HIGH" regionUniRule annotationAdd BLAST11
Motifi242 – 246"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252721
KOiK01885
OMAiLYPCYET
OrthoDBiPOG091H021W

Family and domain databases

Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A7HS42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGAPVVRFA PSPTGSLHVG NARAALFNFL FARKNSGKFM LRMDDTDDER
60 70 80 90 100
STVEFAAGIE EDLTWLGLRH DLFARQSDRL AAYEAAAAKL KADGRLYPAY
110 120 130 140 150
ETAAELDRKR KRQMARGLPP VYDRAALALT DEDRAKLEAE GRKPHWRFRL
160 170 180 190 200
DRVHTAFDDL VQGAVEVDGA SLSDPVLIRE DGRFLYTLPS VVDDIDFAVT
210 220 230 240 250
HVIRGSDHIT NTGVQIQIIR ALGAEPPVYA HYSLLNGPEG KPLSKRDDAA
260 270 280 290 300
RFSLRALRDA GFEPMALNSL LARLGTPDAV EPCLSLDELA ARFDISRLGR
310 320 330 340 350
ADIRFDPADL AKVNTACLHL MSYEEAKPRL AALGCDLGEA FWEAIKPNLI
360 370 380 390 400
LFSDAADWAR VVEGPVEPVI ENPDFAAAAA AALPPEPWDE STWALWTDAV
410 420 430 440
KQATGAKGKA LFMPLRLALT GLTHGPELKN LLPLIGRERA SARLGGLTR
Length:449
Mass (Da):49,180
Last modified:September 11, 2007 - v1
Checksum:i214F6D8EBB9C309F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000774 Genomic DNA Translation: ABS62725.1
RefSeqiWP_012109981.1, NC_009719.1

Genome annotation databases

EnsemblBacteriaiABS62725; ABS62725; Plav_1104
KEGGipla:Plav_1104

Similar proteinsi

Entry informationi

Entry nameiSYE1_PARL1
AccessioniPrimary (citable) accession number: A7HS42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 11, 2007
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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