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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciPLAV402881:G1G9L-708-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Plav_0690
OrganismiParvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Taxonomic identifieri402881 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhodobiaceaeParvibaculum
Proteomesi
  • UP000006377 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000727701 – 448Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST448

Proteomic databases

PRIDEiA7HQY0

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi402881.Plav_0690

Structurei

3D structure databases

ProteinModelPortaliA7HQY0
SMRiA7HQY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

A7HQY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYLPLTEND RREMLGVIGA KSVDELFRDV PERARREGLV DLPRRQGELE
60 70 80 90 100
VERMLGRMAA KNTPAASVPF FVGAGAYRHH VPAAVDHLIQ RSEFLTSYTP
110 120 130 140 150
YQPEITQGTL QYLFEFQTQV AMITGMEVAN ASMYDGATGC GEAVLMAHRV
160 170 180 190 200
TKRRKAVLSG TLHPQYAAVV QNLSDFADYE LEVMPPALPG QAEDILAHIH
210 220 230 240 250
DDISCVVVQT PGFFGELHDL RPIAEAAHAK GALLIAVVPE ILSLGAVTPP
260 270 280 290 300
GEMGADIVVG EGQSIGNGLN FGGPYVGLFA TREKYMRQMP GRLCGETVDA
310 320 330 340 350
DGNRGFVLTL STREQHIRRE KATSNICTNS GLCCLAFTIH MSLLGEEGYK
360 370 380 390 400
RLARINHAAA VKLAERLAKV PGVEILNQAF FNEFTMRLPK PAAEVVDALV
410 420 430 440
DKGVIGGLPA SRLLPGVAEV EDLLIVASTE INTEADRAAY EAALKEVL
Length:448
Mass (Da):48,643
Last modified:September 11, 2007 - v1
Checksum:i2327A643B776FF8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000774 Genomic DNA Translation: ABS62313.1
RefSeqiWP_011995604.1, NC_009719.1

Genome annotation databases

EnsemblBacteriaiABS62313; ABS62313; Plav_0690
KEGGipla:Plav_0690

Similar proteinsi

Entry informationi

Entry nameiGCSPA_PARL1
AccessioniPrimary (citable) accession number: A7HQY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 11, 2007
Last modified: April 25, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health