Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A7HQY0 (GCSPA_PARL1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:Plav_0690
OrganismParvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966) [Complete proteome] [HAMAP]
Taxonomic identifier402881 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhodobiaceaeParvibaculum

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000072770

Sequences

Sequence LengthMass (Da)Tools
A7HQY0 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 2327A643B776FF8B

FASTA44848,643
        10         20         30         40         50         60 
MRYLPLTEND RREMLGVIGA KSVDELFRDV PERARREGLV DLPRRQGELE VERMLGRMAA 

        70         80         90        100        110        120 
KNTPAASVPF FVGAGAYRHH VPAAVDHLIQ RSEFLTSYTP YQPEITQGTL QYLFEFQTQV 

       130        140        150        160        170        180 
AMITGMEVAN ASMYDGATGC GEAVLMAHRV TKRRKAVLSG TLHPQYAAVV QNLSDFADYE 

       190        200        210        220        230        240 
LEVMPPALPG QAEDILAHIH DDISCVVVQT PGFFGELHDL RPIAEAAHAK GALLIAVVPE 

       250        260        270        280        290        300 
ILSLGAVTPP GEMGADIVVG EGQSIGNGLN FGGPYVGLFA TREKYMRQMP GRLCGETVDA 

       310        320        330        340        350        360 
DGNRGFVLTL STREQHIRRE KATSNICTNS GLCCLAFTIH MSLLGEEGYK RLARINHAAA 

       370        380        390        400        410        420 
VKLAERLAKV PGVEILNQAF FNEFTMRLPK PAAEVVDALV DKGVIGGLPA SRLLPGVAEV 

       430        440 
EDLLIVASTE INTEADRAAY EAALKEVL 

« Hide

References

[1]"Complete genome sequence and annotation of Parvibaculum lavamentivorans DS-1."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DS-1 / DSM 13023 / NCIMB 13966.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000774 Genomic DNA. Translation: ABS62313.1.
RefSeqYP_001411970.1. NC_009719.1.

3D structure databases

ProteinModelPortalA7HQY0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING402881.Plav_0690.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS62313; ABS62313; Plav_0690.
GeneID5455940.
KEGGpla:Plav_0690.
PATRIC22862938. VBIParLav90819_0712.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMASMYDGST.
OrthoDBEOG6XWV3B.
ProtClustDBPRK00451.

Enzyme and pathway databases

BioCycPLAV402881:GHQA-700-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_PARL1
AccessionPrimary (citable) accession number: A7HQY0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 11, 2007
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families