A7HQX5 (KHSE_PARL1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	Plav_0685

Organism

Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966) [Complete proteome] [HAMAP]

Taxonomic identifier

402881 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Parvibaculum

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Homoserine kinase HAMAP MF_00301		PRO_1000071979

Sequences

	Sequence		Length	Mass (Da)
	A7HQX5 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 9DEE382A2E49C451	FASTA	321	35,865
	10 20 30 40 50 60 MAVYTEVPDE ELEAFLATYD IGTLMSYKGI AEGVENSNFM LHTDAGTYFL TLYEKRVAES 70 80 90 100 110 120 ELPFFLGLMN HLVDRGISCP TPIRNRKGEM LGRLAERPAA IVSFLEGISV RRPQPRHCVE 130 140 150 160 170 180 LGRALAQLHM AGADFKLARK NALNVDGWGP LFDSCRDGID AYQPGLAQEL DKELAVLTRE 190 200 210 220 230 240 WPRDLPHGVI HADLFPDNVF FIGDRLSGLI DFYFACNDAF AYDLAICLNA WCFEADGSFN 250 260 270 280 290 300 ITKARALLQA YTQVRPLEPA EIHALPLLAR GSAMRFLLTR LYDLINHPPG AFVKPKDPKE 310 320 YLTRLRFHRG VASPAGYGLD A

References

[1]

"Complete genome sequence and annotation of Parvibaculum lavamentivorans DS-1." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DS-1 / DSM 13023 / NCIMB 13966.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000774 Genomic DNA. Translation: ABS62308.1.
RefSeq	YP_001411965.1. NC_009719.1.
3D structure databases
ProteinModelPortal	A7HQX5.
SMR	A7HQX5. Positions 5-319.
ModBase	Search...
Protein-protein interaction databases
STRING	A7HQX5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5456985.
GenomeReviews	Gene locus Plav_0685 in contig CP000774_GR.
KEGG	pla:Plav_0685.
PATRIC	22862928. VBIParLav90819_0707.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2334.
HOGENOM	HBG309377.
OMA	ICLNAWC.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_PARL1

Accession

Primary (citable) accession number: A7HQX5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	September 11, 2007
Last modified:	December 14, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program