A7HQR4 (LPXK_PARL1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tetraacyldisaccharide 4'-kinase
EC=2.7.1.130

Alternative name(s):
Lipid A 4'-kinase

Gene names

Name:	lpxK
Ordered Locus Names:	Plav_0624

Organism

Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966) [Complete proteome] [HAMAP]

Taxonomic identifier

402881 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Parvibaculum

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) By similarity. HAMAP MF_00409
Catalytic activity	ATP + (2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate) = ADP + (2-N,3-O-bis(3-hydroxytetradecanoyl)-4-O-phosphono-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate). HAMAP MF_00409
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6. HAMAP MF_00409
Sequence similarities	Belongs to the LpxK family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW tetraacyldisaccharide 4'-kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 342	342	Tetraacyldisaccharide 4'-kinase HAMAP MF_00409		PRO_0000340844
Regions
	Nucleotide binding	56 – 63	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A7HQR4 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: EE0AD5DCB1151B60	FASTA	342	36,235
	10 20 30 40 50 60 MREPRFWYPA QRNSVPLAAR LLAPLGYVYG LAGRIRRGRA EPQRAAVPVI CVGNLTAGGA 70 80 90 100 110 120 GKTPVALTLA EGLIAKGEKV HFLTRGYGGR EQGPIRVDPL RHAAADVGDE PLLLAAAAPT 130 140 150 160 170 180 WVAANRSEGA AAAVRGGAGL IIMDDGFQNP GLAKDFSILV VDAASGVGNG RLVPAGPLRE 190 200 210 220 230 240 RVDDALSRAN ALILTGRGHA GDGIAARARA RGIPVFNSIV RPAVAPDFGA GPFLAFAGIG 250 260 270 280 290 300 RPEKFYRTLR ELGAELAETI SFPDHHMFSE SEALKLLVRA RELGARLITT EKDAARLSHA 310 320 330 340 PVSSARWRLD EAALRLPVRA LIGDFPSLMA QIDDAVSRAR RR

References

[1]

"Complete genome sequence and annotation of Parvibaculum lavamentivorans DS-1." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DS-1 / DSM 13023 / NCIMB 13966.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000774 Genomic DNA. Translation: ABS62247.1.
RefSeq	YP_001411904.1. NC_009719.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A7HQR4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5455748.
GenomeReviews	Gene locus Plav_0624 in contig CP000774_GR.
KEGG	pla:Plav_0624.
PATRIC	22862804. VBIParLav90819_0645.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1663.
HOGENOM	HBG663914.
OMA	VILMDDG.
Family and domain databases
HAMAP	MF_00409. LpxK. [Tree]
InterPro	IPR003758. Tetraacyldisaccharide_4-kinase. [Graphical view]
KO	K00912.
Pfam	PF02606. LpxK. 1 hit. [Graphical view]
TIGRFAMs	TIGR00682. LpxK. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXK_PARL1

Accession

Primary (citable) accession number: A7HQR4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	September 11, 2007
Last modified:	December 14, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program