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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciPLAV402881:G1G9L-271-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:Plav_0262
OrganismiParvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Taxonomic identifieri402881 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhodobiaceaeParvibaculum
Proteomesi
  • UP000006377 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000716621 – 310Methionyl-tRNA formyltransferaseAdd BLAST310

Interactioni

Protein-protein interaction databases

STRINGi402881.Plav_0262

Structurei

3D structure databases

ProteinModelPortaliA7HPQ2
SMRiA7HPQ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 112Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
IPR001555 GART_AS
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit
PROSITEiView protein in PROSITE
PS00373 GART, 1 hit

Sequencei

Sequence statusi: Complete.

A7HPQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLAFMGTPD FSVPVLAEIL AAGHEVVAVY SQPPRKAGRG MAEQPSPVHR
60 70 80 90 100
FAEEHGIPVF TPVSLKGEAE QQAFASLDLD VAVVVAYGLI LPKPVLEAPR
110 120 130 140 150
LGCLNLHASL LPRWRGAAPI QRAIMAGDAE TGVMVMQMEE GLDTGPVLLA
160 170 180 190 200
ERVAIAPDET AGGLHDRLSH IGASLMVRAL AALSRGGLAA APQPEEGVTY
210 220 230 240 250
ARKIEKAEAR IDWRRPANEL DCHIRGLTPF PGAFFEIARG GETIRVKILR
260 270 280 290 300
AKPVAKSGEP GKVLDAGESI IIACGEGALE ISGLQRAGKA AVTARDFLRG
310
FALKPGESVA
Length:310
Mass (Da):32,716
Last modified:September 11, 2007 - v1
Checksum:iFCC32EF157EADFCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000774 Genomic DNA Translation: ABS61885.1
RefSeqiWP_011995176.1, NC_009719.1

Genome annotation databases

EnsemblBacteriaiABS61885; ABS61885; Plav_0262
KEGGipla:Plav_0262

Similar proteinsi

Entry informationi

Entry nameiFMT_PARL1
AccessioniPrimary (citable) accession number: A7HPQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 11, 2007
Last modified: March 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health