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A7HN82

- SYL_FERNB

UniProt

A7HN82 - SYL_FERNB

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei581 – 5811ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciFNOD381764:GC5M-1574-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Fnod_1522
    OrganismiFervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
    Taxonomic identifieri381764 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeFervidobacterium
    ProteomesiUP000002415: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 819819Leucine--tRNA ligasePRO_1000071110Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi381764.Fnod_1522.

    Structurei

    3D structure databases

    ProteinModelPortaliA7HN82.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi41 – 5111"HIGH" regionAdd
    BLAST
    Motifi578 – 5825"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiERYWMNV.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7HN82-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKEYKPQEIE SKWQGVWSEK KVFETPQYSD KKKYYALVMF PYPSGTLHVG    50
    HVKNYVIGDI VARYKRMQGY NVLHPFGYDA FGLPAENAAI AHKIHPKKWT 100
    LDNINVIRGQ IKKIGISYDW NREVITCTED YYKWTQWVFL KLYEAGLAYK 150
    KPGAVNWCPS CQTVLANEQV KDGKCERCGT TVTMKYLEQW YFKITDYAEK 200
    LLEGLDRLPG WPEHVKTMQR NWIGKSTGAE VDFPVDGMDR KIRIFTTRPD 250
    TIYGVTFMAI APESPLVMEL VTEDKKKEVE EFLAKVALED RFKRTSVEAK 300
    KEGVFLGRYA INPLTNEKIP IYVANYILYE YGTGAIMAVP AHDQRDYDFA 350
    KTYNLPIKQV IKPKDGEWNI NERPYEEEGI MINSGPFDGL ESSKGIEEVT 400
    KYIEEKGFGK KSVQYKLRDW LISRQRYWGA PIPIVYCEKC GIVPVPEKDL 450
    PVRLPENVEF LPTGQSPLTL SEEFKHTTCP KCGGPAHREV ETMDTFVDSS 500
    WYFLRYVNPK LDDKPFESDD VNYWLPVDQY IGGVEHAVLH LLYSRFITKV 550
    LHDLGYLKFD EPFENLFTQG MIYKDGWKMS KSKGNVVSPD DMINKYGADT 600
    LRMYILFMAP PEKDAEWNDA GIDGVNRFIK RLWNNYYKIL DIINSNDTKN 650
    ENEFGKEEKN LRRKLHAMIK KIKEDIEGGF KFNTAIAGLM EFNNQLSDYL 700
    ENTKSPNKKL LREIAEKVVL ILSPFAPHMA EEMWHDLGKE TLIVEEKWPE 750
    YDPEALKEDE LTIVVQVNGK VRGKITVPAD ASEEEIKNRA VENAGKFLEG 800
    KTIVNTIYVK GKLVNIVIK 819
    Length:819
    Mass (Da):94,678
    Last modified:September 11, 2007 - v1
    Checksum:iFB35036960663EDB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000771 Genomic DNA. Translation: ABS61365.1.
    RefSeqiWP_011994670.1. NC_009718.1.
    YP_001411022.1. NC_009718.1.

    Genome annotation databases

    EnsemblBacteriaiABS61365; ABS61365; Fnod_1522.
    GeneIDi5451965.
    KEGGifno:Fnod_1522.
    PATRICi21884601. VBIFerNod12464_1582.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000771 Genomic DNA. Translation: ABS61365.1 .
    RefSeqi WP_011994670.1. NC_009718.1.
    YP_001411022.1. NC_009718.1.

    3D structure databases

    ProteinModelPortali A7HN82.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 381764.Fnod_1522.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS61365 ; ABS61365 ; Fnod_1522 .
    GeneIDi 5451965.
    KEGGi fno:Fnod_1522.
    PATRICi 21884601. VBIFerNod12464_1582.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi ERYWMNV.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci FNOD381764:GC5M-1574-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35602 / DSM 5306 / Rt17-B1.

    Entry informationi

    Entry nameiSYL_FERNB
    AccessioniPrimary (citable) accession number: A7HN82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3