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Protein

Methylenetetrahydrofolate reductase

Gene

Fnod_1279

Organism
Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H.UniRule annotation

Cofactori

FADUniRule annotation

GO - Molecular functioni

  1. methylenetetrahydrofolate reductase (NAD(P)H) activity Source: UniProtKB-EC

GO - Biological processi

  1. methionine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein

Enzyme and pathway databases

BioCyciFNOD381764:GC5M-1330-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate reductaseUniRule annotation (EC:1.5.1.20UniRule annotation)
Gene namesi
Ordered Locus Names:Fnod_1279Imported
OrganismiFervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)Imported
Taxonomic identifieri381764 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeFervidobacterium
ProteomesiUP000002415 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi381764.Fnod_1279.

Structurei

3D structure databases

ProteinModelPortaliA7HMJ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methylenetetrahydrofolate reductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0685.
HOGENOMiHOG000246233.
KOiK00297.
OMAiQKYFEFV.
OrthoDBiEOG6D2KVW.

Family and domain databases

Gene3Di3.20.20.220. 1 hit.
InterProiIPR029041. FAD-linked_oxidoreductase-like.
IPR003171. Mehydrof_redctse.
[Graphical view]
PfamiPF02219. MTHFR. 1 hit.
[Graphical view]
SUPFAMiSSF51730. SSF51730. 1 hit.

Sequencei

Sequence statusi: Complete.

A7HMJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIVEKLRNE KIVSIEIIPP KRGEDVEKIF ATLDKLMDYN ISFINITRHP
60 70 80 90 100
SEIDYLETEN GIIKVQKIKR PGTIGLTAAL MKRYNIDVVP HLVCKGMNKF
110 120 130 140 150
EMEDILIDLS IMGVENVFVV RGEEVKSVAK SDYKYASDLV KQISDMNNGR
160 170 180 190 200
YLYTEAKPTN FCIGVAGYPE KHFEAPNLDV DLRFLKQKVD NGADFIITQM
210 220 230 240 250
VFDAAIYEKF VEKSRSMGIN IPIIPGVKPV VSKKSIYSIP KKFFVNIPQK
260 270 280 290 300
FVEKMEEAKS ESEEFEIGVR FTVELIKNLL EKDAPGVHIF TMGRGEEVCK
310
VLKLLREGGI LNV
Length:313
Mass (Da):35,602
Last modified:September 10, 2007 - v1
Checksum:iB78F4416EC01F4FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000771 Genomic DNA. Translation: ABS61126.1.
RefSeqiYP_001410783.1. NC_009718.1.

Genome annotation databases

EnsemblBacteriaiABS61126; ABS61126; Fnod_1279.
KEGGifno:Fnod_1279.
PATRICi21884099. VBIFerNod12464_1332.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000771 Genomic DNA. Translation: ABS61126.1.
RefSeqiYP_001410783.1. NC_009718.1.

3D structure databases

ProteinModelPortaliA7HMJ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi381764.Fnod_1279.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS61126; ABS61126; Fnod_1279.
KEGGifno:Fnod_1279.
PATRICi21884099. VBIFerNod12464_1332.

Phylogenomic databases

eggNOGiCOG0685.
HOGENOMiHOG000246233.
KOiK00297.
OMAiQKYFEFV.
OrthoDBiEOG6D2KVW.

Enzyme and pathway databases

BioCyciFNOD381764:GC5M-1330-MONOMER.

Family and domain databases

Gene3Di3.20.20.220. 1 hit.
InterProiIPR029041. FAD-linked_oxidoreductase-like.
IPR003171. Mehydrof_redctse.
[Graphical view]
PfamiPF02219. MTHFR. 1 hit.
[Graphical view]
SUPFAMiSSF51730. SSF51730. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35602 / DSM 5306 / Rt17-B1Imported.

Entry informationi

Entry nameiA7HMJ3_FERNB
AccessioniPrimary (citable) accession number: A7HMJ3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 10, 2007
Last sequence update: September 10, 2007
Last modified: March 31, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.