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A7HMJ3

- A7HMJ3_FERNB

UniProt

A7HMJ3 - A7HMJ3_FERNB

Protein

Methylenetetrahydrofolate reductase

Gene

Fnod_1279

Organism
Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    GO - Molecular functioni

    1. methylenetetrahydrofolate reductase (NAD(P)H) activity Source: UniProtKB-EC

    GO - Biological processi

    1. methionine metabolic process Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Ligandi

    FADUniRule annotation, Flavoprotein

    Enzyme and pathway databases

    BioCyciFNOD381764:GC5M-1330-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methylenetetrahydrofolate reductaseUniRule annotation (EC:1.5.1.20UniRule annotation)
    Gene namesi
    Ordered Locus Names:Fnod_1279Imported
    OrganismiFervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)Imported
    Taxonomic identifieri381764 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeFervidobacterium
    ProteomesiUP000002415: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi381764.Fnod_1279.

    Structurei

    3D structure databases

    ProteinModelPortaliA7HMJ3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the methylenetetrahydrofolate reductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0685.
    HOGENOMiHOG000246233.
    KOiK00297.
    OMAiAIKQCED.
    OrthoDBiEOG6D2KVW.

    Family and domain databases

    Gene3Di3.20.20.220. 1 hit.
    InterProiIPR029041. FAD-linked_oxidoreductase-like.
    IPR003171. Mehydrof_redctse.
    [Graphical view]
    PfamiPF02219. MTHFR. 1 hit.
    [Graphical view]
    SUPFAMiSSF51730. SSF51730. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7HMJ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIVEKLRNE KIVSIEIIPP KRGEDVEKIF ATLDKLMDYN ISFINITRHP    50
    SEIDYLETEN GIIKVQKIKR PGTIGLTAAL MKRYNIDVVP HLVCKGMNKF 100
    EMEDILIDLS IMGVENVFVV RGEEVKSVAK SDYKYASDLV KQISDMNNGR 150
    YLYTEAKPTN FCIGVAGYPE KHFEAPNLDV DLRFLKQKVD NGADFIITQM 200
    VFDAAIYEKF VEKSRSMGIN IPIIPGVKPV VSKKSIYSIP KKFFVNIPQK 250
    FVEKMEEAKS ESEEFEIGVR FTVELIKNLL EKDAPGVHIF TMGRGEEVCK 300
    VLKLLREGGI LNV 313
    Length:313
    Mass (Da):35,602
    Last modified:September 11, 2007 - v1
    Checksum:iB78F4416EC01F4FD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000771 Genomic DNA. Translation: ABS61126.1.
    RefSeqiYP_001410783.1. NC_009718.1.

    Genome annotation databases

    EnsemblBacteriaiABS61126; ABS61126; Fnod_1279.
    GeneIDi5452562.
    KEGGifno:Fnod_1279.
    PATRICi21884099. VBIFerNod12464_1332.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000771 Genomic DNA. Translation: ABS61126.1 .
    RefSeqi YP_001410783.1. NC_009718.1.

    3D structure databases

    ProteinModelPortali A7HMJ3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 381764.Fnod_1279.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS61126 ; ABS61126 ; Fnod_1279 .
    GeneIDi 5452562.
    KEGGi fno:Fnod_1279.
    PATRICi 21884099. VBIFerNod12464_1332.

    Phylogenomic databases

    eggNOGi COG0685.
    HOGENOMi HOG000246233.
    KOi K00297.
    OMAi AIKQCED.
    OrthoDBi EOG6D2KVW.

    Enzyme and pathway databases

    BioCyci FNOD381764:GC5M-1330-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.220. 1 hit.
    InterProi IPR029041. FAD-linked_oxidoreductase-like.
    IPR003171. Mehydrof_redctse.
    [Graphical view ]
    Pfami PF02219. MTHFR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51730. SSF51730. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35602 / DSM 5306 / Rt17-B1Imported.

    Entry informationi

    Entry nameiA7HMJ3_FERNB
    AccessioniPrimary (citable) accession number: A7HMJ3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 11, 2007
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3