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A7HMJ3

- A7HMJ3_FERNB

UniProt

A7HMJ3 - A7HMJ3_FERNB

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Protein

Methylenetetrahydrofolate reductase

Gene

Fnod_1279

Organism
Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Status
Unreviewed - Annotation score: 1 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H.UniRule annotation

Cofactori

Note: FAD.UniRule annotation

GO - Molecular functioni

  1. methylenetetrahydrofolate reductase (NAD(P)H) activity Source: UniProtKB-EC

GO - Biological processi

  1. methionine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein

Enzyme and pathway databases

BioCyciFNOD381764:GC5M-1330-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate reductaseUniRule annotation (EC:1.5.1.20UniRule annotation)
Gene namesi
Ordered Locus Names:Fnod_1279Imported
OrganismiFervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)Imported
Taxonomic identifieri381764 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeFervidobacterium
ProteomesiUP000002415: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi381764.Fnod_1279.

Structurei

3D structure databases

ProteinModelPortaliA7HMJ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methylenetetrahydrofolate reductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0685.
HOGENOMiHOG000246233.
KOiK00297.
OMAiAIKQCED.
OrthoDBiEOG6D2KVW.

Family and domain databases

Gene3Di3.20.20.220. 1 hit.
InterProiIPR029041. FAD-linked_oxidoreductase-like.
IPR003171. Mehydrof_redctse.
[Graphical view]
PfamiPF02219. MTHFR. 1 hit.
[Graphical view]
SUPFAMiSSF51730. SSF51730. 1 hit.

Sequencei

Sequence statusi: Complete.

A7HMJ3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIVEKLRNE KIVSIEIIPP KRGEDVEKIF ATLDKLMDYN ISFINITRHP
60 70 80 90 100
SEIDYLETEN GIIKVQKIKR PGTIGLTAAL MKRYNIDVVP HLVCKGMNKF
110 120 130 140 150
EMEDILIDLS IMGVENVFVV RGEEVKSVAK SDYKYASDLV KQISDMNNGR
160 170 180 190 200
YLYTEAKPTN FCIGVAGYPE KHFEAPNLDV DLRFLKQKVD NGADFIITQM
210 220 230 240 250
VFDAAIYEKF VEKSRSMGIN IPIIPGVKPV VSKKSIYSIP KKFFVNIPQK
260 270 280 290 300
FVEKMEEAKS ESEEFEIGVR FTVELIKNLL EKDAPGVHIF TMGRGEEVCK
310
VLKLLREGGI LNV
Length:313
Mass (Da):35,602
Last modified:September 11, 2007 - v1
Checksum:iB78F4416EC01F4FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000771 Genomic DNA. Translation: ABS61126.1.
RefSeqiWP_011994435.1. NC_009718.1.
YP_001410783.1. NC_009718.1.

Genome annotation databases

EnsemblBacteriaiABS61126; ABS61126; Fnod_1279.
GeneIDi5452562.
KEGGifno:Fnod_1279.
PATRICi21884099. VBIFerNod12464_1332.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000771 Genomic DNA. Translation: ABS61126.1 .
RefSeqi WP_011994435.1. NC_009718.1.
YP_001410783.1. NC_009718.1.

3D structure databases

ProteinModelPortali A7HMJ3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 381764.Fnod_1279.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS61126 ; ABS61126 ; Fnod_1279 .
GeneIDi 5452562.
KEGGi fno:Fnod_1279.
PATRICi 21884099. VBIFerNod12464_1332.

Phylogenomic databases

eggNOGi COG0685.
HOGENOMi HOG000246233.
KOi K00297.
OMAi AIKQCED.
OrthoDBi EOG6D2KVW.

Enzyme and pathway databases

BioCyci FNOD381764:GC5M-1330-MONOMER.

Family and domain databases

Gene3Di 3.20.20.220. 1 hit.
InterProi IPR029041. FAD-linked_oxidoreductase-like.
IPR003171. Mehydrof_redctse.
[Graphical view ]
Pfami PF02219. MTHFR. 1 hit.
[Graphical view ]
SUPFAMi SSF51730. SSF51730. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35602 / DSM 5306 / Rt17-B1Imported.

Entry informationi

Entry nameiA7HMJ3_FERNB
AccessioniPrimary (citable) accession number: A7HMJ3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 26, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3