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A7HLZ4

- FTHS_FERNB

UniProt

A7HLZ4 - FTHS_FERNB

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFNOD381764:GC5M-1121-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Fnod_1079
OrganismiFervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Taxonomic identifieri381764 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeFervidobacterium
ProteomesiUP000002415: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 552552Formate--tetrahydrofolate ligasePRO_1000073555Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi381764.Fnod_1079.

Structurei

3D structure databases

ProteinModelPortaliA7HLZ4.
SMRiA7HLZ4. Positions 4-550.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiDPKKINA.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7HLZ4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSDIEIAKQ ARLKDIRDIA KFLDIPEDML KPYGRYIAKV DHRYLNTLNA
60 70 80 90 100
KPNGKLILVT AITPTPAGEG KTTTSIGLSM ALNRIGKKSI VTLREPSLGP
110 120 130 140 150
VFGVKGGAAG GGYSQVLPME DINLHFTGDI HAVTTAHNLI AAMIDAHINH
160 170 180 190 200
GNELGIDLRK IYWKRAMDMN DRALREIVIA LGGSANGYPR EDGFLITAAS
210 220 230 240 250
EIMAVLCLAK DLTDLKRRIG EIVIAQGKNG LVRVKDIQAE GAAAALLKDA
260 270 280 290 300
INPNLVQTIE NTPAFVHGGP FANIAHGTNT LIATKLALKL SDYVVTEAGF
310 320 330 340 350
AADLGAQKFL DFVAPTGGLF VDAVVIVASI RAMKYHGGVS KDNLNEENVD
360 370 380 390 400
AVIKGLENLK VHIENMKKYG VPVVVALNRF STDTEKEIEA VLKNSPAKCV
410 420 430 440 450
LNEAYAKGSE GAIELAKAVV ETIENVPSNY KPLVPSDLPV EQKIELIAKE
460 470 480 490 500
IYRAGKVIYT DTAKSKLSML KKNGFGNYPV IIAKTQNSIS DDPKKINAPS
510 520 530 540 550
GYEFTVRDFQ ISAGAGFVVA LAGEIMLMPG LPKAPAAVNI DIDENGEITG

LF
Length:552
Mass (Da):59,243
Last modified:September 11, 2007 - v1
Checksum:iC92C5736F192B44D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000771 Genomic DNA. Translation: ABS60927.1.
RefSeqiWP_011994240.1. NC_009718.1.
YP_001410584.1. NC_009718.1.

Genome annotation databases

EnsemblBacteriaiABS60927; ABS60927; Fnod_1079.
GeneIDi5452644.
KEGGifno:Fnod_1079.
PATRICi21883675. VBIFerNod12464_1128.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000771 Genomic DNA. Translation: ABS60927.1 .
RefSeqi WP_011994240.1. NC_009718.1.
YP_001410584.1. NC_009718.1.

3D structure databases

ProteinModelPortali A7HLZ4.
SMRi A7HLZ4. Positions 4-550.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 381764.Fnod_1079.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS60927 ; ABS60927 ; Fnod_1079 .
GeneIDi 5452644.
KEGGi fno:Fnod_1079.
PATRICi 21883675. VBIFerNod12464_1128.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi DPKKINA.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci FNOD381764:GC5M-1121-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35602 / DSM 5306 / Rt17-B1.

Entry informationi

Entry nameiFTHS_FERNB
AccessioniPrimary (citable) accession number: A7HLZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 11, 2007
Last modified: October 1, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3