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A7HLZ4 (FTHS_FERNB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Fnod_1079
OrganismFervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1) [Complete proteome] [HAMAP]
Taxonomic identifier381764 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeFervidobacterium

Protein attributes

Sequence length552 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 552552Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000073555

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A7HLZ4 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: C92C5736F192B44D

FASTA55259,243
        10         20         30         40         50         60 
MLSDIEIAKQ ARLKDIRDIA KFLDIPEDML KPYGRYIAKV DHRYLNTLNA KPNGKLILVT 

        70         80         90        100        110        120 
AITPTPAGEG KTTTSIGLSM ALNRIGKKSI VTLREPSLGP VFGVKGGAAG GGYSQVLPME 

       130        140        150        160        170        180 
DINLHFTGDI HAVTTAHNLI AAMIDAHINH GNELGIDLRK IYWKRAMDMN DRALREIVIA 

       190        200        210        220        230        240 
LGGSANGYPR EDGFLITAAS EIMAVLCLAK DLTDLKRRIG EIVIAQGKNG LVRVKDIQAE 

       250        260        270        280        290        300 
GAAAALLKDA INPNLVQTIE NTPAFVHGGP FANIAHGTNT LIATKLALKL SDYVVTEAGF 

       310        320        330        340        350        360 
AADLGAQKFL DFVAPTGGLF VDAVVIVASI RAMKYHGGVS KDNLNEENVD AVIKGLENLK 

       370        380        390        400        410        420 
VHIENMKKYG VPVVVALNRF STDTEKEIEA VLKNSPAKCV LNEAYAKGSE GAIELAKAVV 

       430        440        450        460        470        480 
ETIENVPSNY KPLVPSDLPV EQKIELIAKE IYRAGKVIYT DTAKSKLSML KKNGFGNYPV 

       490        500        510        520        530        540 
IIAKTQNSIS DDPKKINAPS GYEFTVRDFQ ISAGAGFVVA LAGEIMLMPG LPKAPAAVNI 

       550 
DIDENGEITG LF 

« Hide

References

[1]"Complete sequence of Fervidobacterium nodosum Rt17-B1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35602 / DSM 5306 / Rt17-B1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000771 Genomic DNA. Translation: ABS60927.1.
RefSeqYP_001410584.1. NC_009718.1.

3D structure databases

ProteinModelPortalA7HLZ4.
SMRA7HLZ4. Positions 4-550.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING381764.Fnod_1079.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS60927; ABS60927; Fnod_1079.
GeneID5452644.
KEGGfno:Fnod_1079.
PATRIC21883675. VBIFerNod12464_1128.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13505.

Enzyme and pathway databases

BioCycFNOD381764:GC5M-1121-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_FERNB
AccessionPrimary (citable) accession number: A7HLZ4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 11, 2007
Last modified: April 16, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways