Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A7HLZ4

- FTHS_FERNB

UniProt

A7HLZ4 - FTHS_FERNB

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciFNOD381764:GC5M-1121-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Fnod_1079
    OrganismiFervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
    Taxonomic identifieri381764 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeFervidobacterium
    ProteomesiUP000002415: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 552552Formate--tetrahydrofolate ligasePRO_1000073555Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi381764.Fnod_1079.

    Structurei

    3D structure databases

    ProteinModelPortaliA7HLZ4.
    SMRiA7HLZ4. Positions 4-550.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiDPKKINA.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7HLZ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSDIEIAKQ ARLKDIRDIA KFLDIPEDML KPYGRYIAKV DHRYLNTLNA    50
    KPNGKLILVT AITPTPAGEG KTTTSIGLSM ALNRIGKKSI VTLREPSLGP 100
    VFGVKGGAAG GGYSQVLPME DINLHFTGDI HAVTTAHNLI AAMIDAHINH 150
    GNELGIDLRK IYWKRAMDMN DRALREIVIA LGGSANGYPR EDGFLITAAS 200
    EIMAVLCLAK DLTDLKRRIG EIVIAQGKNG LVRVKDIQAE GAAAALLKDA 250
    INPNLVQTIE NTPAFVHGGP FANIAHGTNT LIATKLALKL SDYVVTEAGF 300
    AADLGAQKFL DFVAPTGGLF VDAVVIVASI RAMKYHGGVS KDNLNEENVD 350
    AVIKGLENLK VHIENMKKYG VPVVVALNRF STDTEKEIEA VLKNSPAKCV 400
    LNEAYAKGSE GAIELAKAVV ETIENVPSNY KPLVPSDLPV EQKIELIAKE 450
    IYRAGKVIYT DTAKSKLSML KKNGFGNYPV IIAKTQNSIS DDPKKINAPS 500
    GYEFTVRDFQ ISAGAGFVVA LAGEIMLMPG LPKAPAAVNI DIDENGEITG 550
    LF 552
    Length:552
    Mass (Da):59,243
    Last modified:September 11, 2007 - v1
    Checksum:iC92C5736F192B44D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000771 Genomic DNA. Translation: ABS60927.1.
    RefSeqiWP_011994240.1. NC_009718.1.
    YP_001410584.1. NC_009718.1.

    Genome annotation databases

    EnsemblBacteriaiABS60927; ABS60927; Fnod_1079.
    GeneIDi5452644.
    KEGGifno:Fnod_1079.
    PATRICi21883675. VBIFerNod12464_1128.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000771 Genomic DNA. Translation: ABS60927.1 .
    RefSeqi WP_011994240.1. NC_009718.1.
    YP_001410584.1. NC_009718.1.

    3D structure databases

    ProteinModelPortali A7HLZ4.
    SMRi A7HLZ4. Positions 4-550.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 381764.Fnod_1079.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS60927 ; ABS60927 ; Fnod_1079 .
    GeneIDi 5452644.
    KEGGi fno:Fnod_1079.
    PATRICi 21883675. VBIFerNod12464_1128.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi DPKKINA.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci FNOD381764:GC5M-1121-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35602 / DSM 5306 / Rt17-B1.

    Entry informationi

    Entry nameiFTHS_FERNB
    AccessioniPrimary (citable) accession number: A7HLZ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3