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A7HLP1

- GCSPB_FERNB

UniProt

A7HLP1 - GCSPB_FERNB

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 2
Gene
gcvPB, Fnod_0974
Organism
Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciFNOD381764:GC5M-1008-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:Fnod_0974
OrganismiFervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Taxonomic identifieri381764 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeFervidobacterium
ProteomesiUP000002415: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation
PRO_1000072772Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei264 – 2641N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi381764.Fnod_0974.

Structurei

3D structure databases

ProteinModelPortaliA7HLP1.
SMRiA7HLP1. Positions 2-476.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiIFERRIK.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A7HLP1-1 [UniParc]FASTAAdd to Basket

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MTIFEKSTSG RKGYELPEYE LPSVDCGIPE HLVRKEKPLL PEVSEVDVVR    50
HYTELASKNY SVDKGFYPLG SCTMKYNPKI NEDMAMLFTQ LHPMQPRETI 100
QGAIDLMGHL KEMLCEITGT DDMTLQPAAG AHGELTGLLV ARAYFEDKGE 150
LDKRRKVLVP DSAHGTNPAS AAMAGFEVVE LKSGKDGCVN LEELKAHLDE 200
NVAVIMLTNP NTLGLFEKDI LTIAKMAHEV GALLYYDGAN LNAIMGRTRP 250
GDMGFDIVHL NLHKTFSTPH GMGGPGSGPI GVKKHLAPYL PVPVIRKAGE 300
KYDLDYNLPK SIGMVRSFYG NFTVMVKAYT YILTMGNKGL KHVSDMAVLN 350
ANYLRAKLSK IYKVAYDRIC MHEFVIDNEE FVKKTGVKTL DIAKRLLDYG 400
LHAPTVYFPL IVHEAMMIEP TETESKRTLD EFIDAMEKIY NEAIENPELV 450
KKAPYKTPIR RLDDVNATKY PVFRYKK 477
Length:477
Mass (Da):53,430
Last modified:September 11, 2007 - v1
Checksum:iD570DF44D8D4FD3B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000771 Genomic DNA. Translation: ABS60824.1.
RefSeqiYP_001410481.1. NC_009718.1.

Genome annotation databases

EnsemblBacteriaiABS60824; ABS60824; Fnod_0974.
GeneIDi5453161.
KEGGifno:Fnod_0974.
PATRICi21883443. VBIFerNod12464_1020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000771 Genomic DNA. Translation: ABS60824.1 .
RefSeqi YP_001410481.1. NC_009718.1.

3D structure databases

ProteinModelPortali A7HLP1.
SMRi A7HLP1. Positions 2-476.
ModBasei Search...

Protein-protein interaction databases

STRINGi 381764.Fnod_0974.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS60824 ; ABS60824 ; Fnod_0974 .
GeneIDi 5453161.
KEGGi fno:Fnod_0974.
PATRICi 21883443. VBIFerNod12464_1020.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi IFERRIK.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci FNOD381764:GC5M-1008-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35602 / DSM 5306 / Rt17-B1.

Entry informationi

Entry nameiGCSPB_FERNB
AccessioniPrimary (citable) accession number: A7HLP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 11, 2007
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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