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A7HLP1

- GCSPB_FERNB

UniProt

A7HLP1 - GCSPB_FERNB

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciFNOD381764:GC5M-1008-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 2UniRule annotation
    Glycine decarboxylase subunit 2UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
    Gene namesi
    Name:gcvPBUniRule annotation
    Ordered Locus Names:Fnod_0974
    OrganismiFervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
    Taxonomic identifieri381764 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeFervidobacterium
    ProteomesiUP000002415: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 477477Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000072772Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei264 – 2641N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi381764.Fnod_0974.

    Structurei

    3D structure databases

    ProteinModelPortaliA7HLP1.
    SMRiA7HLP1. Positions 2-476.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239368.
    KOiK00283.
    OMAiIFERRIK.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00713. GcvPB.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7HLP1-1 [UniParc]FASTAAdd to Basket

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    MTIFEKSTSG RKGYELPEYE LPSVDCGIPE HLVRKEKPLL PEVSEVDVVR    50
    HYTELASKNY SVDKGFYPLG SCTMKYNPKI NEDMAMLFTQ LHPMQPRETI 100
    QGAIDLMGHL KEMLCEITGT DDMTLQPAAG AHGELTGLLV ARAYFEDKGE 150
    LDKRRKVLVP DSAHGTNPAS AAMAGFEVVE LKSGKDGCVN LEELKAHLDE 200
    NVAVIMLTNP NTLGLFEKDI LTIAKMAHEV GALLYYDGAN LNAIMGRTRP 250
    GDMGFDIVHL NLHKTFSTPH GMGGPGSGPI GVKKHLAPYL PVPVIRKAGE 300
    KYDLDYNLPK SIGMVRSFYG NFTVMVKAYT YILTMGNKGL KHVSDMAVLN 350
    ANYLRAKLSK IYKVAYDRIC MHEFVIDNEE FVKKTGVKTL DIAKRLLDYG 400
    LHAPTVYFPL IVHEAMMIEP TETESKRTLD EFIDAMEKIY NEAIENPELV 450
    KKAPYKTPIR RLDDVNATKY PVFRYKK 477
    Length:477
    Mass (Da):53,430
    Last modified:September 11, 2007 - v1
    Checksum:iD570DF44D8D4FD3B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000771 Genomic DNA. Translation: ABS60824.1.
    RefSeqiYP_001410481.1. NC_009718.1.

    Genome annotation databases

    EnsemblBacteriaiABS60824; ABS60824; Fnod_0974.
    GeneIDi5453161.
    KEGGifno:Fnod_0974.
    PATRICi21883443. VBIFerNod12464_1020.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000771 Genomic DNA. Translation: ABS60824.1 .
    RefSeqi YP_001410481.1. NC_009718.1.

    3D structure databases

    ProteinModelPortali A7HLP1.
    SMRi A7HLP1. Positions 2-476.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 381764.Fnod_0974.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS60824 ; ABS60824 ; Fnod_0974 .
    GeneIDi 5453161.
    KEGGi fno:Fnod_0974.
    PATRICi 21883443. VBIFerNod12464_1020.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239368.
    KOi K00283.
    OMAi IFERRIK.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci FNOD381764:GC5M-1008-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00713. GcvPB.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35602 / DSM 5306 / Rt17-B1.

    Entry informationi

    Entry nameiGCSPB_FERNB
    AccessioniPrimary (citable) accession number: A7HLP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3