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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciFNOD381764:G1G9K-936-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:Fnod_0907
OrganismiFervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Taxonomic identifieri381764 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesFervidobacteriaceaeFervidobacterium
Proteomesi
  • UP000002415 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000716611 – 310Methionyl-tRNA formyltransferaseAdd BLAST310

Interactioni

Protein-protein interaction databases

STRINGi381764.Fnod_0907

Structurei

3D structure databases

ProteinModelPortaliA7HLH4
SMRiA7HLH4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni106 – 109Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

A7HLH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRILFMGTPE FAASYLDFLI QKKFNVVAVI SQKDKPRGRG QKLLPTPVKE
60 70 80 90 100
VAQKYGIPVF QPSKLNEEGL EIIENYRPDI GIVVAYGRLL RKPFLDAIPL
110 120 130 140 150
YNVHTSLLPK YRGPAPMQRA IENGERVTGV TIFKISEGMD EGDIALQRAF
160 170 180 190 200
ELEECEPFGS VYEKFIKYGT ELLQEFLRNY PVTLTPQDHS KATYAPKIEK
210 220 230 240 250
KDLYVDFSKP AVEVRNKIRA YDPTPGVRTF LNDIEVKLYG ACEIESNSQE
260 270 280 290 300
NIEPGTVVRI EKQSGDGVIK TIDGLLHIKY IQFPGKNKIT FLSAKNGGLI
310
KEGMVFRNLD
Length:310
Mass (Da):35,065
Last modified:September 11, 2007 - v1
Checksum:iE2DF36A5F2D9BB04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000771 Genomic DNA Translation: ABS60757.1
RefSeqiWP_011994072.1, NC_009718.1

Genome annotation databases

EnsemblBacteriaiABS60757; ABS60757; Fnod_0907
KEGGifno:Fnod_0907

Similar proteinsi

Entry informationi

Entry nameiFMT_FERNB
AccessioniPrimary (citable) accession number: A7HLH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 11, 2007
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health