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Protein

Glutamate--tRNA ligase 2

Gene

gltX2

Organism
Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei241ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFNOD381764:G1G9K-793-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 2UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 2UniRule annotation
Short name:
GluRS 2UniRule annotation
Gene namesi
Name:gltX2UniRule annotation
Ordered Locus Names:Fnod_0777
OrganismiFervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Taxonomic identifieri381764 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesFervidobacteriaceaeFervidobacterium
Proteomesi
  • UP000002415 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003676731 – 467Glutamate--tRNA ligase 2Add BLAST467

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi381764.Fnod_0777

Structurei

3D structure databases

ProteinModelPortaliA7HL47
SMRiA7HL47
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi18 – 28"HIGH" regionUniRule annotationAdd BLAST11
Motifi238 – 242"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252720
KOiK01885
OMAiHYINTLP
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
1.10.1160.10, 1 hit
3.40.50.620, 2 hits
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR020061 Glu_tRNA_lig_a-bdl
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 2 hits
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A7HL47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQEINQKSQ EVRVRFAPSP TGYLHVGGAR TALFNWLFAR KNNGKFVLRI
60 70 80 90 100
EDTDTERSTR ESEQMIMNDL KWLGLYWDEG PDIGGNYGPY RQSERLEIYK
110 120 130 140 150
KYAYELVEKG YAYFAIYDEN DPKKVIEKTT KEPKTKNPFT VVFKVPENKV
160 170 180 190 200
IAFDDMLKGR IEFSTEHMED FIILKSNGYS VYNYAVVIDD HFMNITHVLR
210 220 230 240 250
GEDHISNTPK QLLLYEAFGW EQPKFMHIPL ILGADKTPLS KRHGATAVEH
260 270 280 290 300
FRKEGYLPKA LVNYLAILGW SVDEEIFDYT QKVQSFMPEQ ISNKNVVFDY
310 320 330 340 350
QKLEWVNGKH MRTLSLDELM KYFKEWQEFT EKKFEIPEKV IEISREKVNT
360 370 380 390 400
LKQLYEFTLP FVDDNYEYSN DYIEKFLKKP EAIHILELGM KKFSDLNDYT
410 420 430 440 450
IENVEKVLRE IAIELNLGTN KVFQTIRGAV LGRLVTPGLF ESIAVLGKEK
460
TLSRIRRTIG MISTIGG
Length:467
Mass (Da):54,534
Last modified:September 11, 2007 - v1
Checksum:i28C88E563DEC020B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000771 Genomic DNA Translation: ABS60630.1
RefSeqiWP_011993947.1, NC_009718.1

Genome annotation databases

EnsemblBacteriaiABS60630; ABS60630; Fnod_0777
KEGGifno:Fnod_0777

Similar proteinsi

Entry informationi

Entry nameiSYE2_FERNB
AccessioniPrimary (citable) accession number: A7HL47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 11, 2007
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health