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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (apgM)
  4. Enolase (eno)
  5. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36SubstrateUniRule annotation1
Binding sitei118SubstrateUniRule annotation1
Binding sitei151SubstrateUniRule annotation1
Binding sitei201ATPUniRule annotation1
Binding sitei293ATP; via carbonyl oxygenUniRule annotation1
Binding sitei324ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi353 – 356ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFNOD381764:G1G9K-751-MONOMER
UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:Fnod_0739
OrganismiFervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Taxonomic identifieri381764 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesFervidobacteriaceaeFervidobacterium
Proteomesi
  • UP000002415 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000714701 – 400Phosphoglycerate kinaseAdd BLAST400

Proteomic databases

PRIDEiA7HL11

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi381764.Fnod_0739

Structurei

3D structure databases

ProteinModelPortaliA7HL11
SMRiA7HL11
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 23Substrate bindingUniRule annotation3
Regioni59 – 62Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
HOGENOMiHOG000227108
KOiK00927
OMAiDMIFDIG
OrthoDBiPOG091H00YN

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 2 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

A7HL11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLTIRDVD LKGKRVIMRV DFNVPIKDGV VTDDTRIVEA LPTIKYVLEQ
60 70 80 90 100
GAKVILLTHL GRPKGGPDPK YTVKPAAERL AQLLGKEVKF VPALYGEEVE
110 120 130 140 150
KAVAELKEGE VLMLENTRFD PGEEKNDLEL AKKWASLADI HVNDAFGTAH
160 170 180 190 200
RAHSSNVGIA QYIPSVAGFL MEKEIKFLSK ATHNPDKPYV VVLGGAKVSD
210 220 230 240 250
KIGVITNLLN KADKIIIGGA MMFTFWRALG KQTGNSLVEE DKIDLAKQLL
260 270 280 290 300
EQAKEKGVEL VIPTDAVCAQ KMEAGVEKKV FTCEEGIPEG WAGYDIGPAS
310 320 330 340 350
IELIKSKLAD AKTIVWNGPL GVFEIEDFAN GTKAVAEFIA SLTDKGVTTV
360 370 380 390 400
VGGGDSAAAV SQFGLEKKFS HVSTGGGASL EFLEGKELPG IASIADKKKQ
Length:400
Mass (Da):43,110
Last modified:September 11, 2007 - v1
Checksum:i022289550D8EEB90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000771 Genomic DNA Translation: ABS60594.1
RefSeqiWP_011993912.1, NC_009718.1

Genome annotation databases

EnsemblBacteriaiABS60594; ABS60594; Fnod_0739
KEGGifno:Fnod_0739

Similar proteinsi

Entry informationi

Entry nameiPGK_FERNB
AccessioniPrimary (citable) accession number: A7HL11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 11, 2007
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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