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A7HKP2

- GCH4_FERNB

UniProt

A7HKP2 - GCH4_FERNB

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei146 – 1461May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciFNOD381764:GC5M-628-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Fnod_0620
    OrganismiFervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
    Taxonomic identifieri381764 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeFervidobacterium
    ProteomesiUP000002415: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 261261GTP cyclohydrolase FolE2PRO_0000372029Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi381764.Fnod_0620.

    Structurei

    3D structure databases

    ProteinModelPortaliA7HKP2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiLIWFEDL.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7HKP2-1 [UniParc]FASTAAdd to Basket

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    MLKDVQNERD NRNIYLKRVG VKDLRYPIVV LDRTNVTQNT IATLNMFVDL    50
    PKDYRGTHMS RFIEVLNEYH LEINPKRIKE ILRSLKKVLN AKRSVIEITF 100
    PFFLLKKAPV TGSESYLEYT CSFEAEMNGD HLDFSTTVTA PIHTLCPCSK 150
    EISEYGAHNQ RAKCSVTFKS KEMVWIEDII EIIEESASAP IFTLLKRADE 200
    KYVTEHAYDN PKFVEDVARD VALRLKKYDK IEWYKVEVES FESIHAHNAY 250
    ACLTSDEIEK I 261
    Length:261
    Mass (Da):30,365
    Last modified:September 11, 2007 - v1
    Checksum:i5F9301E4A0C00D0C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000771 Genomic DNA. Translation: ABS60475.1.
    RefSeqiWP_011993794.1. NC_009718.1.
    YP_001410132.1. NC_009718.1.

    Genome annotation databases

    EnsemblBacteriaiABS60475; ABS60475; Fnod_0620.
    GeneIDi5451899.
    KEGGifno:Fnod_0620.
    PATRICi21882675. VBIFerNod12464_0658.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000771 Genomic DNA. Translation: ABS60475.1 .
    RefSeqi WP_011993794.1. NC_009718.1.
    YP_001410132.1. NC_009718.1.

    3D structure databases

    ProteinModelPortali A7HKP2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 381764.Fnod_0620.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS60475 ; ABS60475 ; Fnod_0620 .
    GeneIDi 5451899.
    KEGGi fno:Fnod_0620.
    PATRICi 21882675. VBIFerNod12464_0658.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi LIWFEDL.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci FNOD381764:GC5M-628-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35602 / DSM 5306 / Rt17-B1.

    Entry informationi

    Entry nameiGCH4_FERNB
    AccessioniPrimary (citable) accession number: A7HKP2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3