Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A7HKP2

- GCH4_FERNB

UniProt

A7HKP2 - GCH4_FERNB

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei146 – 1461May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciFNOD381764:GC5M-628-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Fnod_0620
OrganismiFervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Taxonomic identifieri381764 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeFervidobacterium
ProteomesiUP000002415: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261GTP cyclohydrolase FolE2PRO_0000372029Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi381764.Fnod_0620.

Structurei

3D structure databases

ProteinModelPortaliA7HKP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiLIWFEDL.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

A7HKP2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKDVQNERD NRNIYLKRVG VKDLRYPIVV LDRTNVTQNT IATLNMFVDL
60 70 80 90 100
PKDYRGTHMS RFIEVLNEYH LEINPKRIKE ILRSLKKVLN AKRSVIEITF
110 120 130 140 150
PFFLLKKAPV TGSESYLEYT CSFEAEMNGD HLDFSTTVTA PIHTLCPCSK
160 170 180 190 200
EISEYGAHNQ RAKCSVTFKS KEMVWIEDII EIIEESASAP IFTLLKRADE
210 220 230 240 250
KYVTEHAYDN PKFVEDVARD VALRLKKYDK IEWYKVEVES FESIHAHNAY
260
ACLTSDEIEK I
Length:261
Mass (Da):30,365
Last modified:September 11, 2007 - v1
Checksum:i5F9301E4A0C00D0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000771 Genomic DNA. Translation: ABS60475.1.
RefSeqiYP_001410132.1. NC_009718.1.

Genome annotation databases

EnsemblBacteriaiABS60475; ABS60475; Fnod_0620.
GeneIDi5451899.
KEGGifno:Fnod_0620.
PATRICi21882675. VBIFerNod12464_0658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000771 Genomic DNA. Translation: ABS60475.1 .
RefSeqi YP_001410132.1. NC_009718.1.

3D structure databases

ProteinModelPortali A7HKP2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 381764.Fnod_0620.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS60475 ; ABS60475 ; Fnod_0620 .
GeneIDi 5451899.
KEGGi fno:Fnod_0620.
PATRICi 21882675. VBIFerNod12464_0658.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi LIWFEDL.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci FNOD381764:GC5M-628-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35602 / DSM 5306 / Rt17-B1.

Entry informationi

Entry nameiGCH4_FERNB
AccessioniPrimary (citable) accession number: A7HKP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: September 11, 2007
Last modified: November 26, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3