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A7HKP2 (GCH4_FERNB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:Fnod_0620
OrganismFervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1) [Complete proteome] [HAMAP]
Taxonomic identifier381764 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeFervidobacterium

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000372029

Sites

Site1461May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
A7HKP2 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 5F9301E4A0C00D0C

FASTA26130,365
        10         20         30         40         50         60 
MLKDVQNERD NRNIYLKRVG VKDLRYPIVV LDRTNVTQNT IATLNMFVDL PKDYRGTHMS 

        70         80         90        100        110        120 
RFIEVLNEYH LEINPKRIKE ILRSLKKVLN AKRSVIEITF PFFLLKKAPV TGSESYLEYT 

       130        140        150        160        170        180 
CSFEAEMNGD HLDFSTTVTA PIHTLCPCSK EISEYGAHNQ RAKCSVTFKS KEMVWIEDII 

       190        200        210        220        230        240 
EIIEESASAP IFTLLKRADE KYVTEHAYDN PKFVEDVARD VALRLKKYDK IEWYKVEVES 

       250        260 
FESIHAHNAY ACLTSDEIEK I 

« Hide

References

[1]"Complete sequence of Fervidobacterium nodosum Rt17-B1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35602 / DSM 5306 / Rt17-B1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000771 Genomic DNA. Translation: ABS60475.1.
RefSeqYP_001410132.1. NC_009718.1.

3D structure databases

ProteinModelPortalA7HKP2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING381764.Fnod_0620.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS60475; ABS60475; Fnod_0620.
GeneID5451899.
KEGGfno:Fnod_0620.
PATRIC21882675. VBIFerNod12464_0658.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280679.
KOK09007.
OMALIWFEDL.
OrthoDBEOG6X6RBH.

Enzyme and pathway databases

BioCycFNOD381764:GC5M-628-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00294. TIGR00294. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCH4_FERNB
AccessionPrimary (citable) accession number: A7HKP2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: September 11, 2007
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways