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A7HKC0

- UVRB_FERNB

UniProt

A7HKC0 - UVRB_FERNB

Protein

UvrABC system protein B

Gene

uvrB

Organism
Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi37 – 448ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: UniProtKB-HAMAP
    3. excinuclease ABC activity Source: UniProtKB-HAMAP
    4. helicase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. nucleotide-excision repair Source: UniProtKB-HAMAP
    2. SOS response Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Excision nuclease, Helicase, Hydrolase

    Keywords - Biological processi

    DNA damage, DNA excision, DNA repair, SOS response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciFNOD381764:GC5M-497-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UvrABC system protein BUniRule annotation
    Short name:
    Protein UvrBUniRule annotation
    Alternative name(s):
    Excinuclease ABC subunit BUniRule annotation
    Gene namesi
    Name:uvrBUniRule annotation
    Ordered Locus Names:Fnod_0489
    OrganismiFervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
    Taxonomic identifieri381764 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeFervidobacterium
    ProteomesiUP000002415: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 661661UvrABC system protein BPRO_1000099552Add
    BLAST

    Interactioni

    Subunit structurei

    Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi381764.Fnod_0489.

    Structurei

    3D structure databases

    ProteinModelPortaliA7HKC0.
    SMRiA7HKC0. Positions 2-590.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 209186Helicase ATP-bindingUniRule annotationAdd
    BLAST
    Domaini430 – 594165Helicase C-terminalUniRule annotationAdd
    BLAST
    Domaini622 – 65736UVRUniRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi90 – 11324Beta-hairpinAdd
    BLAST

    Domaini

    The beta-hairpin motif is involved in DNA binding.UniRule annotation

    Sequence similaritiesi

    Belongs to the UvrB family.UniRule annotation
    Contains 1 helicase ATP-binding domain.UniRule annotation
    Contains 1 helicase C-terminal domain.UniRule annotation
    Contains 1 UVR domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0556.
    HOGENOMiHOG000073580.
    KOiK03702.
    OMAiIDLVPAH.
    OrthoDBiEOG6B360R.

    Family and domain databases

    Gene3Di3.40.50.300. 4 hits.
    4.10.860.10. 1 hit.
    HAMAPiMF_00204. UvrB.
    InterProiIPR006935. Helicase/UvrB_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR001943. UVR_dom.
    IPR004807. UvrB.
    IPR024759. UvrB_YAD/RRR_dom.
    [Graphical view]
    PANTHERiPTHR24029. PTHR24029. 1 hit.
    PfamiPF00271. Helicase_C. 1 hit.
    PF04851. ResIII. 1 hit.
    PF02151. UVR. 1 hit.
    PF12344. UvrB. 1 hit.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view]
    SUPFAMiSSF46600. SSF46600. 1 hit.
    SSF52540. SSF52540. 3 hits.
    TIGRFAMsiTIGR00631. uvrb. 1 hit.
    PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50151. UVR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7HKC0-1 [UniParc]FASTAAdd to Basket

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    MPYELISDYE PMGDQPQAIE SLVNGLNKGY RFQTLLGVTG SGKTFTMANV    50
    IKEVNRPVLI ISPNKTLAAQ LYSEFKAFFP NNKVEFFISY YDYYQPEAYV 100
    PTKDLYIEKS ADINDVIARM RMSAIKSIMT RRDVIVVASV SAIYACGDPR 150
    DFDTLNIKLE VGQRINLSEF VKKLVKIGYE RKEDIGLTGS FRLRGDTLEI 200
    FPSYQDEGIR IELFGDEIDR MYTFDRMNRD VIERLDRLTI YPTKEYVTTE 250
    EKIERAVKSI RAELDEQVKK LRSEGKELEA QRLWQRTMND IELLSTLGYC 300
    TGIENYSRHF DGRQPGEPPY SLLDYYDEDF IVFIDESHIT IPQLRAMYHG 350
    EMSRKKSLVE YGFRLPCAYD NRPLKFDEFM QKVNQVIFVS ATPGPYELEV 400
    SEQVVEQIIR PTGLIDPQVE VRPTRYQVDD LVNEIVQVKK RGEKALVTVL 450
    TKKTAEMLAE YLVEFNIRAL YLHSELDAIK RVEVLKKLRA GEIDVVVGVN 500
    LLREGLDLPE VSLVAILDAD TEGFLRSETT LIQIIGRTAR NENGKVIMYA 550
    DRITPAMQRA IDETNRRRKI QMEYNEKHGI KPKTIIKPLM EDIFAPFRDK 600
    EEEMYKVYED SILQMKESLS LEEYAALLEE EMYKAASELR YEDAARLRDE 650
    LFKIKEELNR N 661
    Length:661
    Mass (Da):76,722
    Last modified:September 11, 2007 - v1
    Checksum:iADBDAB62C682D654
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000771 Genomic DNA. Translation: ABS60353.1.
    RefSeqiWP_011993673.1. NC_009718.1.
    YP_001410010.1. NC_009718.1.

    Genome annotation databases

    EnsemblBacteriaiABS60353; ABS60353; Fnod_0489.
    GeneIDi5453153.
    KEGGifno:Fnod_0489.
    PATRICi21882379. VBIFerNod12464_0510.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000771 Genomic DNA. Translation: ABS60353.1 .
    RefSeqi WP_011993673.1. NC_009718.1.
    YP_001410010.1. NC_009718.1.

    3D structure databases

    ProteinModelPortali A7HKC0.
    SMRi A7HKC0. Positions 2-590.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 381764.Fnod_0489.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS60353 ; ABS60353 ; Fnod_0489 .
    GeneIDi 5453153.
    KEGGi fno:Fnod_0489.
    PATRICi 21882379. VBIFerNod12464_0510.

    Phylogenomic databases

    eggNOGi COG0556.
    HOGENOMi HOG000073580.
    KOi K03702.
    OMAi IDLVPAH.
    OrthoDBi EOG6B360R.

    Enzyme and pathway databases

    BioCyci FNOD381764:GC5M-497-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 4 hits.
    4.10.860.10. 1 hit.
    HAMAPi MF_00204. UvrB.
    InterProi IPR006935. Helicase/UvrB_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR001943. UVR_dom.
    IPR004807. UvrB.
    IPR024759. UvrB_YAD/RRR_dom.
    [Graphical view ]
    PANTHERi PTHR24029. PTHR24029. 1 hit.
    Pfami PF00271. Helicase_C. 1 hit.
    PF04851. ResIII. 1 hit.
    PF02151. UVR. 1 hit.
    PF12344. UvrB. 1 hit.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46600. SSF46600. 1 hit.
    SSF52540. SSF52540. 3 hits.
    TIGRFAMsi TIGR00631. uvrb. 1 hit.
    PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50151. UVR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35602 / DSM 5306 / Rt17-B1.

    Entry informationi

    Entry nameiUVRB_FERNB
    AccessioniPrimary (citable) accession number: A7HKC0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3