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A7HKC0

- UVRB_FERNB

UniProt

A7HKC0 - UVRB_FERNB

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Protein
UvrABC system protein B
Gene
uvrB, Fnod_0489
Organism
Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 448ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: UniProtKB-HAMAP
  3. excinuclease ABC activity Source: UniProtKB-HAMAP
  4. helicase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. SOS response Source: UniProtKB-HAMAP
  2. nucleotide-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease, Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFNOD381764:GC5M-497-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein B
Short name:
Protein UvrB
Alternative name(s):
Excinuclease ABC subunit B
Gene namesi
Name:uvrB
Ordered Locus Names:Fnod_0489
OrganismiFervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Taxonomic identifieri381764 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeFervidobacterium
ProteomesiUP000002415: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 661661UvrABC system protein BUniRule annotation
PRO_1000099552Add
BLAST

Interactioni

Subunit structurei

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex By similarity.

Protein-protein interaction databases

STRINGi381764.Fnod_0489.

Structurei

3D structure databases

ProteinModelPortaliA7HKC0.
SMRiA7HKC0. Positions 2-590.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 209186Helicase ATP-binding
Add
BLAST
Domaini430 – 594165Helicase C-terminal
Add
BLAST
Domaini622 – 65736UVR
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi90 – 11324Beta-hairpinUniRule annotation
Add
BLAST

Domaini

The beta-hairpin motif is involved in DNA binding By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the UvrB family.
Contains 1 UVR domain.

Phylogenomic databases

eggNOGiCOG0556.
HOGENOMiHOG000073580.
KOiK03702.
OMAiIDLVPAH.
OrthoDBiEOG6B360R.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
4.10.860.10. 1 hit.
HAMAPiMF_00204. UvrB.
InterProiIPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
[Graphical view]
PANTHERiPTHR24029. PTHR24029. 1 hit.
PfamiPF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00631. uvrb. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7HKC0-1 [UniParc]FASTAAdd to Basket

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MPYELISDYE PMGDQPQAIE SLVNGLNKGY RFQTLLGVTG SGKTFTMANV    50
IKEVNRPVLI ISPNKTLAAQ LYSEFKAFFP NNKVEFFISY YDYYQPEAYV 100
PTKDLYIEKS ADINDVIARM RMSAIKSIMT RRDVIVVASV SAIYACGDPR 150
DFDTLNIKLE VGQRINLSEF VKKLVKIGYE RKEDIGLTGS FRLRGDTLEI 200
FPSYQDEGIR IELFGDEIDR MYTFDRMNRD VIERLDRLTI YPTKEYVTTE 250
EKIERAVKSI RAELDEQVKK LRSEGKELEA QRLWQRTMND IELLSTLGYC 300
TGIENYSRHF DGRQPGEPPY SLLDYYDEDF IVFIDESHIT IPQLRAMYHG 350
EMSRKKSLVE YGFRLPCAYD NRPLKFDEFM QKVNQVIFVS ATPGPYELEV 400
SEQVVEQIIR PTGLIDPQVE VRPTRYQVDD LVNEIVQVKK RGEKALVTVL 450
TKKTAEMLAE YLVEFNIRAL YLHSELDAIK RVEVLKKLRA GEIDVVVGVN 500
LLREGLDLPE VSLVAILDAD TEGFLRSETT LIQIIGRTAR NENGKVIMYA 550
DRITPAMQRA IDETNRRRKI QMEYNEKHGI KPKTIIKPLM EDIFAPFRDK 600
EEEMYKVYED SILQMKESLS LEEYAALLEE EMYKAASELR YEDAARLRDE 650
LFKIKEELNR N 661
Length:661
Mass (Da):76,722
Last modified:September 11, 2007 - v1
Checksum:iADBDAB62C682D654
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000771 Genomic DNA. Translation: ABS60353.1.
RefSeqiWP_011993673.1. NC_009718.1.
YP_001410010.1. NC_009718.1.

Genome annotation databases

EnsemblBacteriaiABS60353; ABS60353; Fnod_0489.
GeneIDi5453153.
KEGGifno:Fnod_0489.
PATRICi21882379. VBIFerNod12464_0510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000771 Genomic DNA. Translation: ABS60353.1 .
RefSeqi WP_011993673.1. NC_009718.1.
YP_001410010.1. NC_009718.1.

3D structure databases

ProteinModelPortali A7HKC0.
SMRi A7HKC0. Positions 2-590.
ModBasei Search...

Protein-protein interaction databases

STRINGi 381764.Fnod_0489.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS60353 ; ABS60353 ; Fnod_0489 .
GeneIDi 5453153.
KEGGi fno:Fnod_0489.
PATRICi 21882379. VBIFerNod12464_0510.

Phylogenomic databases

eggNOGi COG0556.
HOGENOMi HOG000073580.
KOi K03702.
OMAi IDLVPAH.
OrthoDBi EOG6B360R.

Enzyme and pathway databases

BioCyci FNOD381764:GC5M-497-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 4 hits.
4.10.860.10. 1 hit.
HAMAPi MF_00204. UvrB.
InterProi IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
[Graphical view ]
PANTHERi PTHR24029. PTHR24029. 1 hit.
Pfami PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF46600. SSF46600. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsi TIGR00631. uvrb. 1 hit.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35602 / DSM 5306 / Rt17-B1.

Entry informationi

Entry nameiUVRB_FERNB
AccessioniPrimary (citable) accession number: A7HKC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 11, 2007
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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