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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciFNOD381764:G1G9K-449-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Fnod_0443
OrganismiFervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Taxonomic identifieri381764 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesFervidobacteriaceaeFervidobacterium
Proteomesi
  • UP000002415 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalUniRule annotationAdd BLAST21
Transmembranei49 – 69HelicalUniRule annotationAdd BLAST21
Transmembranei75 – 95HelicalUniRule annotationAdd BLAST21
Transmembranei104 – 124HelicalUniRule annotationAdd BLAST21
Transmembranei130 – 150HelicalUniRule annotationAdd BLAST21
Transmembranei160 – 180HelicalUniRule annotationAdd BLAST21
Transmembranei182 – 202HelicalUniRule annotationAdd BLAST21
Transmembranei209 – 229HelicalUniRule annotationAdd BLAST21
Transmembranei234 – 254HelicalUniRule annotationAdd BLAST21
Transmembranei284 – 304HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003325351 – 306Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST306

Proteomic databases

PRIDEiA7HK75

Interactioni

Protein-protein interaction databases

STRINGi381764.Fnod_0443

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
HOGENOMiHOG000275124
KOiK01000
OMAiLMSPLHH
OrthoDBiPOG091H00VH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

A7HK75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIYSAATLL AEFVLGIIIF PKFIDYMKKL KLGQYIRQEG PDLHNYKEGT
60 70 80 90 100
PTAGGIVFIS LTVIAGLILK LPKELIFTLL FYGFIGFLDD FVSIVKKRSL
110 120 130 140 150
GLRAWQKLAL QFLFSIWIAY TILQYRTSSI FGITVPSWLF YLFTMLLVSG
160 170 180 190 200
YSNATNLTDG IDGLAGWVFV TSMIPFMFFS KSSMEYKAIF VIIMPLLSFL
210 220 230 240 250
VYNTRPAKVF MGDTGSLALG AYISTYALMT NNELSLLFFT PIFLLETISV
260 270 280 290 300
ILQVSSYKLR GKRLFKMAPI HHHFELLGWK EEKIVGVFSA WNLAIAIFYI

AFFLNR
Length:306
Mass (Da):34,822
Last modified:September 11, 2007 - v1
Checksum:iB3C7F85E40D67431
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000771 Genomic DNA Translation: ABS60308.1
RefSeqiWP_011993628.1, NC_009718.1

Genome annotation databases

EnsemblBacteriaiABS60308; ABS60308; Fnod_0443
KEGGifno:Fnod_0443

Similar proteinsi

Entry informationi

Entry nameiMRAY_FERNB
AccessioniPrimary (citable) accession number: A7HK75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 11, 2007
Last modified: February 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health