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A7HK24

- PNP_FERNB

UniProt

A7HK24 - PNP_FERNB

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi490 – 4901MagnesiumUniRule annotation
Metal bindingi496 – 4961MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciFNOD381764:GC5M-399-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Fnod_0392
OrganismiFervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Taxonomic identifieri381764 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeFervidobacterium
ProteomesiUP000002415: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 693693Polyribonucleotide nucleotidyltransferasePRO_0000329646Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi381764.Fnod_0392.

Structurei

3D structure databases

ProteinModelPortaliA7HK24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini557 – 61761KHUniRule annotationAdd
BLAST
Domaini627 – 69165S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiGTENTIC.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7HK24 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKEWRKNLFG REWLFQHGKV AKQSAGSIWA RFGDSVVLAT VNVSDNVVEG
60 70 80 90 100
IDFVPLTVEF MEKFYAAGKI PGGFVKREGK PSESGILSSR LIDRPIRPLF
110 120 130 140 150
PKNLRNEVQV IVTVLSVDPN CPTDVLGITA ASLALNISRV PFDGIVAGVQ
160 170 180 190 200
IGYVDGQFIV FPTAEQLERS KIDIVVAGTK DAITMVEGEA KEVTEEEMLQ
210 220 230 240 250
ALMTAHEAIK QIVAFQEEVI KEFNVEKMPL PEPKYNVELV EKFVEYIDMT
260 270 280 290 300
ELEKRIFARG KQERAEMADE YYESIVQKFF EDNNIPEEEQ EEYAIPLKEK
310 320 330 340 350
YDEISKKLMR KIIIERGLRA DGRGPKDIRP ITCEVGLLPR THGSSLFTRG
360 370 380 390 400
ETQSLGIVTL GSPAEEQIID TLIEEGTKRF ILHYNFPPFS TGEVKPLRGP
410 420 430 440 450
SRREIGHGHL AERAVKAIIP PEDEFPYVIR VVSEILESNG SSSMATVCSA
460 470 480 490 500
SLALMDAGVP TKKHVAGVAM GLILEEGKGV ILTDIIGLED HWGDMDFKVA
510 520 530 540 550
GTKDGITAFQ MDCKVSGVSE ELLRQALYQA KEARMFILDK LYETISEPRK
560 570 580 590 600
ELSPYAPRIS WFFIDPTRSG ELIGPGGKTI KSIIKMFDVE ISLDDSTGKV
610 620 630 640 650
TVSGVDAEKV QEAVEYIQNM FRDISIGDLY TGKVTRVENY GIFVEIMPGK
660 670 680 690
IGLVHSSKLG NVKPTSFKVG DKIKVEVINI DDAGRLQFRR LEE
Length:693
Mass (Da):77,260
Last modified:September 11, 2007 - v1
Checksum:i7AF154E51ECD6C01
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000771 Genomic DNA. Translation: ABS60257.1.
RefSeqiWP_011993577.1. NC_009718.1.
YP_001409914.1. NC_009718.1.

Genome annotation databases

EnsemblBacteriaiABS60257; ABS60257; Fnod_0392.
GeneIDi5452181.
KEGGifno:Fnod_0392.
PATRICi21882173. VBIFerNod12464_0408.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000771 Genomic DNA. Translation: ABS60257.1 .
RefSeqi WP_011993577.1. NC_009718.1.
YP_001409914.1. NC_009718.1.

3D structure databases

ProteinModelPortali A7HK24.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 381764.Fnod_0392.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS60257 ; ABS60257 ; Fnod_0392 .
GeneIDi 5452181.
KEGGi fno:Fnod_0392.
PATRICi 21882173. VBIFerNod12464_0408.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi GTENTIC.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci FNOD381764:GC5M-399-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35602 / DSM 5306 / Rt17-B1.

Entry informationi

Entry nameiPNP_FERNB
AccessioniPrimary (citable) accession number: A7HK24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 11, 2007
Last modified: October 29, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3