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Protein

Probable nicotinate-nucleotide adenylyltransferase

Gene

nadD

Organism
Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).UniRule annotation

Catalytic activityi

ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable nicotinate-nucleotide adenylyltransferase (nadD)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, NAD, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00332.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable nicotinate-nucleotide adenylyltransferaseUniRule annotation (EC:2.7.7.18UniRule annotation)
Alternative name(s):
Deamido-NAD(+) diphosphorylaseUniRule annotation
Deamido-NAD(+) pyrophosphorylaseUniRule annotation
Nicotinate mononucleotide adenylyltransferaseUniRule annotation
Short name:
NaMN adenylyltransferaseUniRule annotation
Gene namesi
Name:nadDUniRule annotation
Ordered Locus Names:Fnod_0367
OrganismiFervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Taxonomic identifieri381764 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesFervidobacteriaceaeFervidobacterium
Proteomesi
  • UP000002415 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003366891 – 215Probable nicotinate-nucleotide adenylyltransferaseAdd BLAST215

Interactioni

Protein-protein interaction databases

STRINGi381764.Fnod_0367.

Structurei

3D structure databases

ProteinModelPortaliA7HJZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NadD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z1W. Bacteria.
COG1057. LUCA.
HOGENOMiHOG000262780.
KOiK00969.
OMAiNGERTSE.
OrthoDBiPOG091H028Y.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00244. NaMN_adenylyltr. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR005248. NAMN_adtrnsfrase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7HJZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSFSKSDTC VIFGGSFNPP HIGHTVILSY ALDYFNADFY IIPTKTPPHK
60 70 80 90 100
VVDIDFDKRF EWVMKSFKCF DTYKKNQIFL WDLEKHIFGV NYAIKNVEYF
110 120 130 140 150
RKYYSNTIIL VGEDALGNIE KWYKYEELLN ITTFAIYPRT RDGSLYKRGQ
160 170 180 190 200
QILGNLYSNV IELRDFPLIE ISSSDIRKRI VEGKSIIGFV DGEILEDVTN
210
TYLMHHKSHG GNWNE
Length:215
Mass (Da):25,157
Last modified:September 11, 2007 - v1
Checksum:iE3832D4A6C8B9D44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000771 Genomic DNA. Translation: ABS60232.1.
RefSeqiWP_011993552.1. NC_009718.1.

Genome annotation databases

EnsemblBacteriaiABS60232; ABS60232; Fnod_0367.
KEGGifno:Fnod_0367.
PATRICi21882119. VBIFerNod12464_0381.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000771 Genomic DNA. Translation: ABS60232.1.
RefSeqiWP_011993552.1. NC_009718.1.

3D structure databases

ProteinModelPortaliA7HJZ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi381764.Fnod_0367.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS60232; ABS60232; Fnod_0367.
KEGGifno:Fnod_0367.
PATRICi21882119. VBIFerNod12464_0381.

Phylogenomic databases

eggNOGiENOG4108Z1W. Bacteria.
COG1057. LUCA.
HOGENOMiHOG000262780.
KOiK00969.
OMAiNGERTSE.
OrthoDBiPOG091H028Y.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00332.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00244. NaMN_adenylyltr. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR005248. NAMN_adtrnsfrase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNADD_FERNB
AccessioniPrimary (citable) accession number: A7HJZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: November 2, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.