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A7HJT4

- UPPP_FERNB

UniProt

A7HJT4 - UPPP_FERNB

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Protein
Undecaprenyl-diphosphatase
Gene
uppP, Fnod_0302
Organism
Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciFNOD381764:GC5M-305-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:Fnod_0302
OrganismiFervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Taxonomic identifieri381764 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeFervidobacterium
ProteomesiUP000002415: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421Helical; Reviewed prediction
Add
BLAST
Transmembranei37 – 5721Helical; Reviewed prediction
Add
BLAST
Transmembranei74 – 9421Helical; Reviewed prediction
Add
BLAST
Transmembranei101 – 12121Helical; Reviewed prediction
Add
BLAST
Transmembranei134 – 15421Helical; Reviewed prediction
Add
BLAST
Transmembranei174 – 19421Helical; Reviewed prediction
Add
BLAST
Transmembranei201 – 22121Helical; Reviewed prediction
Add
BLAST
Transmembranei223 – 24321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Undecaprenyl-diphosphataseUniRule annotation
PRO_1000072893Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi381764.Fnod_0302.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiNIAFAAM.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7HJT4-1 [UniParc]FASTAAdd to Basket

« Hide

MKEFFLGIIQ GLTEFLPVSS SGHLALFSKI ISFPSDLALF AFFHIATFFA    50
VFILLFNDIW NILYGLVRSD KNMWNLALKI IISSIPAGIV GLFFESKVEA 100
AFSSQKLIGV FFLVTAAALW LSDKYSGNKT LNDITYLDAL IVGLFQAIAV 150
LPGISRSGFT LIGALLIGMT RVDAFKYSFL LSLPITLAAG LLELKNVDLT 200
TATLSGFAGA FISGLVALIL VRFVTISAHL KYFSIYLLIP AIVSFFMK 248
Length:248
Mass (Da):27,105
Last modified:September 11, 2007 - v1
Checksum:iC4EDAFFC5CA9E9FE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000771 Genomic DNA. Translation: ABS60167.1.
RefSeqiYP_001409824.1. NC_009718.1.

Genome annotation databases

EnsemblBacteriaiABS60167; ABS60167; Fnod_0302.
GeneIDi5451553.
KEGGifno:Fnod_0302.
PATRICi21881977. VBIFerNod12464_0314.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000771 Genomic DNA. Translation: ABS60167.1 .
RefSeqi YP_001409824.1. NC_009718.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 381764.Fnod_0302.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS60167 ; ABS60167 ; Fnod_0302 .
GeneIDi 5451553.
KEGGi fno:Fnod_0302.
PATRICi 21881977. VBIFerNod12464_0314.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi NIAFAAM.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci FNOD381764:GC5M-305-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35602 / DSM 5306 / Rt17-B1.

Entry informationi

Entry nameiUPPP_FERNB
AccessioniPrimary (citable) accession number: A7HJT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 11, 2007
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi