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A7HJT4 (UPPP_FERNB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Fnod_0302
OrganismFervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1) [Complete proteome] [HAMAP]
Taxonomic identifier381764 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeFervidobacterium

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 248248Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000072893

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane37 – 5721Helical; Potential
Transmembrane74 – 9421Helical; Potential
Transmembrane101 – 12121Helical; Potential
Transmembrane134 – 15421Helical; Potential
Transmembrane174 – 19421Helical; Potential
Transmembrane201 – 22121Helical; Potential
Transmembrane223 – 24321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A7HJT4 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: C4EDAFFC5CA9E9FE

FASTA24827,105
        10         20         30         40         50         60 
MKEFFLGIIQ GLTEFLPVSS SGHLALFSKI ISFPSDLALF AFFHIATFFA VFILLFNDIW 

        70         80         90        100        110        120 
NILYGLVRSD KNMWNLALKI IISSIPAGIV GLFFESKVEA AFSSQKLIGV FFLVTAAALW 

       130        140        150        160        170        180 
LSDKYSGNKT LNDITYLDAL IVGLFQAIAV LPGISRSGFT LIGALLIGMT RVDAFKYSFL 

       190        200        210        220        230        240 
LSLPITLAAG LLELKNVDLT TATLSGFAGA FISGLVALIL VRFVTISAHL KYFSIYLLIP 


AIVSFFMK 

« Hide

References

[1]"Complete sequence of Fervidobacterium nodosum Rt17-B1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35602 / DSM 5306 / Rt17-B1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000771 Genomic DNA. Translation: ABS60167.1.
RefSeqYP_001409824.1. NC_009718.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING381764.Fnod_0302.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS60167; ABS60167; Fnod_0302.
GeneID5451553.
KEGGfno:Fnod_0302.
PATRIC21881977. VBIFerNod12464_0314.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMANIAFAAM.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycFNOD381764:GC5M-305-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_FERNB
AccessionPrimary (citable) accession number: A7HJT4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 11, 2007
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families