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A7HJT4

- UPPP_FERNB

UniProt

A7HJT4 - UPPP_FERNB

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciFNOD381764:GC5M-305-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:Fnod_0302
    OrganismiFervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
    Taxonomic identifieri381764 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeFervidobacterium
    ProteomesiUP000002415: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 248248Undecaprenyl-diphosphatasePRO_1000072893Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi381764.Fnod_0302.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalUniRule annotationAdd
    BLAST
    Transmembranei37 – 5721HelicalUniRule annotationAdd
    BLAST
    Transmembranei74 – 9421HelicalUniRule annotationAdd
    BLAST
    Transmembranei101 – 12121HelicalUniRule annotationAdd
    BLAST
    Transmembranei134 – 15421HelicalUniRule annotationAdd
    BLAST
    Transmembranei174 – 19421HelicalUniRule annotationAdd
    BLAST
    Transmembranei201 – 22121HelicalUniRule annotationAdd
    BLAST
    Transmembranei223 – 24321HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiNIAFAAM.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7HJT4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKEFFLGIIQ GLTEFLPVSS SGHLALFSKI ISFPSDLALF AFFHIATFFA    50
    VFILLFNDIW NILYGLVRSD KNMWNLALKI IISSIPAGIV GLFFESKVEA 100
    AFSSQKLIGV FFLVTAAALW LSDKYSGNKT LNDITYLDAL IVGLFQAIAV 150
    LPGISRSGFT LIGALLIGMT RVDAFKYSFL LSLPITLAAG LLELKNVDLT 200
    TATLSGFAGA FISGLVALIL VRFVTISAHL KYFSIYLLIP AIVSFFMK 248
    Length:248
    Mass (Da):27,105
    Last modified:September 11, 2007 - v1
    Checksum:iC4EDAFFC5CA9E9FE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000771 Genomic DNA. Translation: ABS60167.1.
    RefSeqiYP_001409824.1. NC_009718.1.

    Genome annotation databases

    EnsemblBacteriaiABS60167; ABS60167; Fnod_0302.
    GeneIDi5451553.
    KEGGifno:Fnod_0302.
    PATRICi21881977. VBIFerNod12464_0314.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000771 Genomic DNA. Translation: ABS60167.1 .
    RefSeqi YP_001409824.1. NC_009718.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 381764.Fnod_0302.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS60167 ; ABS60167 ; Fnod_0302 .
    GeneIDi 5451553.
    KEGGi fno:Fnod_0302.
    PATRICi 21881977. VBIFerNod12464_0314.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi NIAFAAM.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci FNOD381764:GC5M-305-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35602 / DSM 5306 / Rt17-B1.

    Entry informationi

    Entry nameiUPPP_FERNB
    AccessioniPrimary (citable) accession number: A7HJT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3