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A7HIX3

- GSA_ANADF

UniProt

A7HIX3 - GSA_ANADF

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Anaeromyxobacter sp. (strain Fw109-5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciASP404589:GHMT-4545-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:Anae109_4491
    OrganismiAnaeromyxobacter sp. (strain Fw109-5)
    Taxonomic identifieri404589 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
    ProteomesiUP000006382: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 429429Glutamate-1-semialdehyde 2,1-aminomutasePRO_1000059976Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei267 – 2671N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi404589.Anae109_4491.

    Structurei

    3D structure databases

    ProteinModelPortaliA7HIX3.
    SMRiA7HIX3. Positions 1-422.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiHYPSIDM.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7HIX3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTELSEKLF AKAQTLFPGG VNSPVRAFRG VGGTPRFIAR GKGSHLFDVD    50
    GNDYVDYVLS WGPMIVGHAH PEVMREVQDA MKEGASFGAP SPREITLAEL 100
    VRERMPWIEK MRFCSSGTEA TTAAIRVARG FTSRDDILKF EGCYHGAGDP 150
    LLVKAGSGVE TLGLPDSPGV PADLAKHTLT LPYNDLAAVE RLFAERGGSI 200
    ACVIIEPVVG NMGVLVPKDG YLQGLLALCR KHGALFIVDE VMTGFRVSSG 250
    GACGLFGVRP DLVTFGKVIG GGLPVGAFGG RADVMDRVAP AGPIYQAGTL 300
    SGNPMAMAAG HATLRLMTGA AYEKLERLSA KLADGLRERA AAAKVPVQVN 350
    RVGSMLTVFF AEQPVFDAAS ARAASTKRFG AFFHRMLEGG AYLPPSQFEA 400
    AFLSTAHSEG DVEQTLHASE AAFAEAAKV 429
    Length:429
    Mass (Da):45,315
    Last modified:September 11, 2007 - v1
    Checksum:iC29FB9E1E38D9778
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000769 Genomic DNA. Translation: ABS28669.1.
    RefSeqiWP_012099319.1. NC_009675.1.
    YP_001381653.1. NC_009675.1.

    Genome annotation databases

    EnsemblBacteriaiABS28669; ABS28669; Anae109_4491.
    GeneIDi5375556.
    KEGGiafw:Anae109_4491.
    PATRICi20934517. VBIAnaSp113478_4694.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000769 Genomic DNA. Translation: ABS28669.1 .
    RefSeqi WP_012099319.1. NC_009675.1.
    YP_001381653.1. NC_009675.1.

    3D structure databases

    ProteinModelPortali A7HIX3.
    SMRi A7HIX3. Positions 1-422.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 404589.Anae109_4491.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS28669 ; ABS28669 ; Anae109_4491 .
    GeneIDi 5375556.
    KEGGi afw:Anae109_4491.
    PATRICi 20934517. VBIAnaSp113478_4694.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi HYPSIDM.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci ASP404589:GHMT-4545-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Fw109-5.

    Entry informationi

    Entry nameiGSA_ANADF
    AccessioniPrimary (citable) accession number: A7HIX3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3