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A7HIJ4 (PURL_ANADF) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine synthase 2

EC=6.3.5.3
Alternative name(s):
Phosphoribosylformylglycinamidine synthase II
Short name=FGAM synthase II
Gene names
Name:purL
Ordered Locus Names:Anae109_4362
OrganismAnaeromyxobacter sp. (strain Fw109-5) [Complete proteome] [HAMAP]
Taxonomic identifier404589 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeAnaeromyxobacter

Protein attributes

Sequence length767 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP MF_00420

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP MF_00420

Subunit structure

Heterodimer of two subunits, PurQ and PurL.

Subcellular location

Cytoplasm By similarity HAMAP MF_00420.

Sequence similarities

Belongs to the FGAMS family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylformylglycinamidine synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 767767Phosphoribosylformylglycinamidine synthase 2 HAMAP MF_00420
PRO_1000050295

Regions

Nucleotide binding103 – 11412ATP Potential

Sequences

Sequence LengthMass (Da)Tools
A7HIJ4 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 7C671AE89BBB4255

FASTA76781,037
        10         20         30         40         50         60 
MTEKITPEVV AQHGLTQAEY DEVKRHLGRE PNLTELGVFS VMWSEHCSYK SSRVHLKTFP 

        70         80         90        100        110        120 
TSGPRVLQGP GENAGVVDLG DGLAAAFKME SHNHPSYIEP YQGAATGVGG ILRDVFTMGA 

       130        140        150        160        170        180 
RPIASANSLR FGDPSHPKTA YLLEGVVAGI GGYGNCMGVP TVAGEVMFHP SYNGNCLVNA 

       190        200        210        220        230        240 
FTLGILPADK IFLGTAAGVG NPVMYIGAKT GRDGIHGATM ASAEFDASTE EKRPTVQVGD 

       250        260        270        280        290        300 
PFMEKLLLEA CLELFKTDAV VGIQDMGAAG FTSSSVEMAG RAGNGLDLFL DQVPLREEGM 

       310        320        330        340        350        360 
TPYEILLSES QERMLLVAAE GKEDMVRKIC TKWDLDVAIV GRVTGTGRWR AHWHGKVVAD 

       370        380        390        400        410        420 
LPVDPLTEGA PKYQRPMTPH PALPALHAFD LSTVPEPADL GDTLLRLLAR PTIASKEWVY 

       430        440        450        460        470        480 
QQYDHMVRLV GAVRPGGDAA VVRIATGDER HAGKGIAISV GANGRYCFLD PHLGAQHAVA 

       490        500        510        520        530        540 
ECARNIACVG GEPIAVTDCL NFGNPEKPEI MWQFAECVRG IGDACRALGT PVVSGNVSLY 

       550        560        570        580        590        600 
NETEGQGILP TPTIGMVGLL PDVEKTCTSA FKNAGDVIAL VGTLQGEVGG SEYLSAEHGR 

       610        620        630        640        650        660 
EAGHPPALDL AKEKAVQETV RRAVREGLLS SAHDCSDGGL AVALAECCMM HGVPAGAEKA 

       670        680        690        700        710        720 
PWIGAAVRVP FPARKDFVLF GEDASRILVS MPKESAARFV ALAQECGAPV IRLGAVGGDT 

       730        740        750        760 
LEIQGALSVP VAELAKAWRD GVPAVLRRDV GHAAASGIAR EPQEPLP 

« Hide

References

[1]"Complete sequence of Anaeromyxobacter sp. Fw109-5."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Lykidis A., Fields M., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Fw109-5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000769 Genomic DNA. Translation: ABS28540.1.
RefSeqYP_001381524.1. NC_009675.1.

3D structure databases

ProteinModelPortalA7HIJ4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7HIJ4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5376534.
GenomeReviewsGene locus Anae109_4362 in contig CP000769_GR.
KEGGafw:Anae109_4362.
NMPDRfig|404589.4.peg.3734.
PATRIC20934251. VBIAnaSp113478_4561.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0046.
HOGENOMHBG311214.
OMAYGNSFGV.
ProtClustDBPRK01213.

Family and domain databases

HAMAPMF_00420. PurL_2.
[Tree]
InterProIPR000728. AIR_synth.
IPR010918. AIR_synth_C.
IPR010074. PRibForGlyAmidine_synth_II.
IPR016188. PurM_N-like.
[Graphical view]
KOK01952.
PfamPF00586. AIRS. 2 hits.
PF02769. AIRS_C. 2 hits.
[Graphical view]
SUPFAMSSF56042. AIR_synth_C. 2 hits.
SSF55326. PurM_N-like. 2 hits.
TIGRFAMsTIGR01736. FGAM_synth_II. 1 hit.
ProtoNetSearch...

Entry information

Entry namePURL_ANADF
AccessionPrimary (citable) accession number: A7HIJ4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 11, 2007
Last modified: January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families