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A7HID3 (DNLI_ANADF) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:Anae109_4301
OrganismAnaeromyxobacter sp. (strain Fw109-5) [Complete proteome] [HAMAP]
Taxonomic identifier404589 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeAnaeromyxobacter

Protein attributes

Sequence length519 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 519519Probable DNA ligase HAMAP-Rule MF_00407
PRO_0000365217

Sites

Active site2131N6-AMP-lysine intermediate By similarity
Binding site2111ATP By similarity
Binding site2181ATP By similarity
Binding site2331ATP By similarity
Binding site2621ATP By similarity
Binding site3021ATP By similarity
Binding site3741ATP By similarity
Binding site3801ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A7HID3 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: B7FAE8869DBF7AE2

FASTA51954,767
        10         20         30         40         50         60 
MQLAELVQTS DVVARTAGRL EKIARLADAL RGLAPEERLA GASWLAGELR QGRIGLGPAA 

        70         80         90        100        110        120 
VRAALEATAP ADAPALAVRE VDASLDRLAA ARGAGSGRER AALLAALLAR ASADERDFLA 

       130        140        150        160        170        180 
RLVLGELRQG ALEGVLVEAV ARAAAVPAGE VRRAVMMAGA LPPVAEAALA EGAAGLSRFR 

       190        200        210        220        230        240 
LRLLEPVQPM LAQPAAGVDE ALAALGEAAL EWKLDGARVQ VHKDGGEVRV FSRALRDVTP 

       250        260        270        280        290        300 
AVPEVVEAVR RLPASSLVLD GEAIALRGDG APEPFQVTMR RFGRKLDVAG LREGVPLSVL 

       310        320        330        340        350        360 
FFDALHTAGE DLIARPASER HLALAAAVPD ALRVPRLVTS DGAAAAAFLE GALARGHEGL 

       370        380        390        400        410        420 
LAKSLTAPYE AGRRGASWLK VKRAHTLDLV VLAAEWGSGR REGFLSNLHL GARDPEGGGF 

       430        440        450        460        470        480 
VMLGKTFKGM TDAMLAWQTE RFRALALGST DGYVVHLRPE LVVEVAFDGL QESSRYPGGL 

       490        500        510 
ALRFARVKRY REDKRPEEAD TIATVRALHA RQVAAERGT 

« Hide

References

[1]"Complete sequence of Anaeromyxobacter sp. Fw109-5."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Lykidis A., Fields M., Richardson P.
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Fw109-5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000769 Genomic DNA. Translation: ABS28479.1.
RefSeqYP_001381463.1. NC_009675.1.

3D structure databases

ProteinModelPortalA7HID3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING404589.Anae109_4301.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABS28479; ABS28479; Anae109_4301.
GeneID5375153.
KEGGafw:Anae109_4301.
PATRIC20934133. VBIAnaSp113478_4502.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK01971.
OMAARVQVHK.
OrthoDBEOG6Q8HXT.

Enzyme and pathway databases

BioCycASP404589:GHMT-4355-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_ANADF
AccessionPrimary (citable) accession number: A7HID3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: September 11, 2007
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families