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A7HID3

- DNLI_ANADF

UniProt

A7HID3 - DNLI_ANADF

Protein

Probable DNA ligase

Gene

lig

Organism
Anaeromyxobacter sp. (strain Fw109-5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei211 – 2111ATPUniRule annotation
    Active sitei213 – 2131N6-AMP-lysine intermediateUniRule annotation
    Binding sitei218 – 2181ATPUniRule annotation
    Binding sitei233 – 2331ATPUniRule annotation
    Binding sitei262 – 2621ATPUniRule annotation
    Binding sitei302 – 3021ATPUniRule annotation
    Binding sitei374 – 3741ATPUniRule annotation
    Binding sitei380 – 3801ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciASP404589:GHMT-4355-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Anae109_4301
    OrganismiAnaeromyxobacter sp. (strain Fw109-5)
    Taxonomic identifieri404589 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
    ProteomesiUP000006382: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 519519Probable DNA ligasePRO_0000365217Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi404589.Anae109_4301.

    Structurei

    3D structure databases

    ProteinModelPortaliA7HID3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1793.
    HOGENOMiHOG000036008.
    KOiK01971.
    OMAiARVQVHK.
    OrthoDBiEOG6Q8HXT.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7HID3-1 [UniParc]FASTAAdd to Basket

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    MQLAELVQTS DVVARTAGRL EKIARLADAL RGLAPEERLA GASWLAGELR    50
    QGRIGLGPAA VRAALEATAP ADAPALAVRE VDASLDRLAA ARGAGSGRER 100
    AALLAALLAR ASADERDFLA RLVLGELRQG ALEGVLVEAV ARAAAVPAGE 150
    VRRAVMMAGA LPPVAEAALA EGAAGLSRFR LRLLEPVQPM LAQPAAGVDE 200
    ALAALGEAAL EWKLDGARVQ VHKDGGEVRV FSRALRDVTP AVPEVVEAVR 250
    RLPASSLVLD GEAIALRGDG APEPFQVTMR RFGRKLDVAG LREGVPLSVL 300
    FFDALHTAGE DLIARPASER HLALAAAVPD ALRVPRLVTS DGAAAAAFLE 350
    GALARGHEGL LAKSLTAPYE AGRRGASWLK VKRAHTLDLV VLAAEWGSGR 400
    REGFLSNLHL GARDPEGGGF VMLGKTFKGM TDAMLAWQTE RFRALALGST 450
    DGYVVHLRPE LVVEVAFDGL QESSRYPGGL ALRFARVKRY REDKRPEEAD 500
    TIATVRALHA RQVAAERGT 519
    Length:519
    Mass (Da):54,767
    Last modified:September 11, 2007 - v1
    Checksum:iB7FAE8869DBF7AE2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000769 Genomic DNA. Translation: ABS28479.1.
    RefSeqiWP_012099123.1. NC_009675.1.
    YP_001381463.1. NC_009675.1.

    Genome annotation databases

    EnsemblBacteriaiABS28479; ABS28479; Anae109_4301.
    GeneIDi5375153.
    KEGGiafw:Anae109_4301.
    PATRICi20934133. VBIAnaSp113478_4502.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000769 Genomic DNA. Translation: ABS28479.1 .
    RefSeqi WP_012099123.1. NC_009675.1.
    YP_001381463.1. NC_009675.1.

    3D structure databases

    ProteinModelPortali A7HID3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 404589.Anae109_4301.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABS28479 ; ABS28479 ; Anae109_4301 .
    GeneIDi 5375153.
    KEGGi afw:Anae109_4301.
    PATRICi 20934133. VBIAnaSp113478_4502.

    Phylogenomic databases

    eggNOGi COG1793.
    HOGENOMi HOG000036008.
    KOi K01971.
    OMAi ARVQVHK.
    OrthoDBi EOG6Q8HXT.

    Enzyme and pathway databases

    BioCyci ASP404589:GHMT-4355-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Fw109-5.

    Entry informationi

    Entry nameiDNLI_ANADF
    AccessioniPrimary (citable) accession number: A7HID3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 3, 2009
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3