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A7HID3

- DNLI_ANADF

UniProt

A7HID3 - DNLI_ANADF

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Protein

Probable DNA ligase

Gene
lig, Anae109_4301
Organism
Anaeromyxobacter sp. (strain Fw109-5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei211 – 2111ATP By similarity
Active sitei213 – 2131N6-AMP-lysine intermediate By similarity
Binding sitei218 – 2181ATP By similarity
Binding sitei233 – 2331ATP By similarity
Binding sitei262 – 2621ATP By similarity
Binding sitei302 – 3021ATP By similarity
Binding sitei374 – 3741ATP By similarity
Binding sitei380 – 3801ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciASP404589:GHMT-4355-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligase (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig
Ordered Locus Names:Anae109_4301
OrganismiAnaeromyxobacter sp. (strain Fw109-5)
Taxonomic identifieri404589 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeAnaeromyxobacter
ProteomesiUP000006382: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519Probable DNA ligaseUniRule annotationPRO_0000365217Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi404589.Anae109_4301.

Structurei

3D structure databases

ProteinModelPortaliA7HID3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK01971.
OMAiARVQVHK.
OrthoDBiEOG6Q8HXT.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7HID3-1 [UniParc]FASTAAdd to Basket

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MQLAELVQTS DVVARTAGRL EKIARLADAL RGLAPEERLA GASWLAGELR    50
QGRIGLGPAA VRAALEATAP ADAPALAVRE VDASLDRLAA ARGAGSGRER 100
AALLAALLAR ASADERDFLA RLVLGELRQG ALEGVLVEAV ARAAAVPAGE 150
VRRAVMMAGA LPPVAEAALA EGAAGLSRFR LRLLEPVQPM LAQPAAGVDE 200
ALAALGEAAL EWKLDGARVQ VHKDGGEVRV FSRALRDVTP AVPEVVEAVR 250
RLPASSLVLD GEAIALRGDG APEPFQVTMR RFGRKLDVAG LREGVPLSVL 300
FFDALHTAGE DLIARPASER HLALAAAVPD ALRVPRLVTS DGAAAAAFLE 350
GALARGHEGL LAKSLTAPYE AGRRGASWLK VKRAHTLDLV VLAAEWGSGR 400
REGFLSNLHL GARDPEGGGF VMLGKTFKGM TDAMLAWQTE RFRALALGST 450
DGYVVHLRPE LVVEVAFDGL QESSRYPGGL ALRFARVKRY REDKRPEEAD 500
TIATVRALHA RQVAAERGT 519
Length:519
Mass (Da):54,767
Last modified:September 11, 2007 - v1
Checksum:iB7FAE8869DBF7AE2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000769 Genomic DNA. Translation: ABS28479.1.
RefSeqiWP_012099123.1. NC_009675.1.
YP_001381463.1. NC_009675.1.

Genome annotation databases

EnsemblBacteriaiABS28479; ABS28479; Anae109_4301.
GeneIDi5375153.
KEGGiafw:Anae109_4301.
PATRICi20934133. VBIAnaSp113478_4502.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000769 Genomic DNA. Translation: ABS28479.1 .
RefSeqi WP_012099123.1. NC_009675.1.
YP_001381463.1. NC_009675.1.

3D structure databases

ProteinModelPortali A7HID3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 404589.Anae109_4301.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABS28479 ; ABS28479 ; Anae109_4301 .
GeneIDi 5375153.
KEGGi afw:Anae109_4301.
PATRICi 20934133. VBIAnaSp113478_4502.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K01971.
OMAi ARVQVHK.
OrthoDBi EOG6Q8HXT.

Enzyme and pathway databases

BioCyci ASP404589:GHMT-4355-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Fw109-5.

Entry informationi

Entry nameiDNLI_ANADF
AccessioniPrimary (citable) accession number: A7HID3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: September 11, 2007
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi