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Protein

Urease subunit alpha

Gene

ureC

Organism
Anaeromyxobacter sp. (strain Fw109-5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Cofactori

Ni cationUniRule annotationNote: Binds 2 nickel ions per subunit.UniRule annotation

Pathwayi: urea degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from urea (urease route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Urease subunit alpha (ureC), Urease subunit beta (ureB)
This subpathway is part of the pathway urea degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from urea (urease route), the pathway urea degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi138Nickel 1; via tele nitrogenUniRule annotation1
Metal bindingi140Nickel 1; via tele nitrogenUniRule annotation1
Metal bindingi221Nickel 1; via carbamate groupUniRule annotation1
Metal bindingi221Nickel 2; via carbamate groupUniRule annotation1
Binding sitei223SubstrateUniRule annotation1
Metal bindingi250Nickel 2; via pros nitrogenUniRule annotation1
Metal bindingi276Nickel 2; via tele nitrogenUniRule annotation1
Active sitei324Proton donorUniRule annotation1
Metal bindingi364Nickel 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Nickel

Enzyme and pathway databases

BioCyciASP404589:G1G9J-4187-MONOMER
UniPathwayiUPA00258; UER00370

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit alphaUniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit alphaUniRule annotation
Gene namesi
Name:ureCUniRule annotation
Ordered Locus Names:Anae109_4049
OrganismiAnaeromyxobacter sp. (strain Fw109-5)
Taxonomic identifieri404589 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
Proteomesi
  • UP000006382 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000706441 – 571Urease subunit alphaAdd BLAST571

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei221N6-carboxylysineUniRule annotation1

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two nickel ions.UniRule annotation

Proteomic databases

PRIDEiA7HHN1

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Protein-protein interaction databases

STRINGi404589.Anae109_4049

Structurei

3D structure databases

ProteinModelPortaliA7HHN1
SMRiA7HHN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 571UreaseUniRule annotationAdd BLAST439

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CQM Bacteria
COG0804 LUCA
HOGENOMiHOG000075064
KOiK01428
OMAiGFDSHIH
OrthoDBiPOG091H0ARR

Family and domain databases

CDDicd00375 Urease_alpha, 1 hit
Gene3Di2.30.40.10, 2 hits
HAMAPiMF_01953 Urease_alpha, 1 hit
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
IPR011612 Urease_alpha_N_dom
IPR017950 Urease_AS
IPR005848 Urease_asu
IPR017951 Urease_asu_c
IPR029754 Urease_Ni-bd
PANTHERiPTHR43440 PTHR43440, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
PF00449 Urease_alpha, 1 hit
PRINTSiPR01752 UREASE
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 2 hits
TIGRFAMsiTIGR01792 urease_alph, 1 hit
PROSITEiView protein in PROSITE
PS01120 UREASE_1, 1 hit
PS00145 UREASE_2, 1 hit
PS51368 UREASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

A7HHN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRRMDRRQY AQVYGPTTGD RVRLGDTALV LEVDRDLTVY GDECVFGGGK
60 70 80 90 100
VLRDGMGQAA GAPPEEVLDL VITNALVLDQ GGVTKADVGI RGGRIAALGK
110 120 130 140 150
AGNPDAMAGV TPGMTIGPGT ECIAGEGLIL TAGGVDSHIH FISPQQAYEA
160 170 180 190 200
IASGVTTMLG GGTGPATGTN ATTCTPGARH VALLLQATDA LPVNIGLLGK
210 220 230 240 250
GNAASPEGLA EQVRAGAVGL KLHEDWGTTP AAIDTCLRVA DQLDVQVAIH
260 270 280 290 300
TDTLNESGCA EHSIAAFAGR TIHTFHTEGA GGGHAPDIIR VCGEPNVLPS
310 320 330 340 350
STNPTRPFTV NTVDEHLDML VVCHHLDPSL PEDLAFAESR IRRETIAAED
360 370 380 390 400
VLHDLGAISM MSSDSQAMGR VGEVVTRTWQ TADKMRRQRG RLPEERGDND
410 420 430 440 450
NLRIRRYLAK YTINPAVAHG LSHEVGSVEP GKLADLVLWR PALFGAKPEL
460 470 480 490 500
VLKGGLIAWA QMGDANASIP TPQPVVARPM FGALGRAVGA TSVAFVSRAS
510 520 530 540 550
LEGGAVQGYG LAKRLVAVHG CRGLGKKDMR LNDALPRMEV DPETYEVRAD
560 570
GVLLRCEPAA RLPLAQRYFL F
Length:571
Mass (Da):60,120
Last modified:September 11, 2007 - v1
Checksum:i92E85E08D8839140
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000769 Genomic DNA Translation: ABS28227.1
RefSeqiWP_012098865.1, NC_009675.1

Genome annotation databases

EnsemblBacteriaiABS28227; ABS28227; Anae109_4049
KEGGiafw:Anae109_4049

Similar proteinsi

Entry informationi

Entry nameiURE1_ANADF
AccessioniPrimary (citable) accession number: A7HHN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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