Reviewed, UniProtKB/Swiss-Prot A7HGZ6 (GCP_ANADF)

Names and origin

Protein names

Recommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	Anae109_3813

Organism

Anaeromyxobacter sp. (strain Fw109-5) [Complete proteome] [HAMAP]

Taxonomic identifier

404589 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Anaeromyxobacter

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445
Cofactor	Zinc Probable.
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 333	333	Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445		PRO_1000024422
Sites
	Metal binding	111	1	Zinc Potential
	Metal binding	115	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	A7HGZ6-1 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 234AAEF99852EAF2	FASTA	333	35,198
	10 20 30 40 50 60 MRILAIETSC DETAAAIVED GRRALADVIS TQIDIHRRWG GVVPELASRN HVVQVMPVVD 70 80 90 100 110 120 EALSRAGVGP DGLDAIAVTS GPGLVGALLV GVQAAKALAL AWQKPLVRVN HLEGHLVAAF 130 140 150 160 170 180 LSETAPAFPY LGLVVSGGHT SLYAAHGFGD YRLLGQTRDD AAGEAFDKGA KLLGLPYPGG 190 200 210 220 230 240 VAIDRLAKEG DARAIRFPKA IVKGADLDFS FSGLKTALLH HVKKHGLPEG KGLADLCASY 250 260 270 280 290 300 QEAIVRALVE KAFRAARRLQ YDRLVLSGGV AANSRLRGAV AERAREYEGM EVFLPAPRLC 310 320 330 TDNAAMIAVA GTHAFLRGER AGADLNADPA WRL

References

[1]

"Complete sequence of Anaeromyxobacter sp. Fw109-5." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Lykidis A., Fields M., Richardson P. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000769 Genomic DNA. Translation: ABS27992.1.
RefSeq	YP_001380976.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A7HGZ6.
Protein family/group databases
MEROPS	M22.001.
Genome annotation databases
GeneID	5375599.
GenomeReviews	Gene locus Anae109_3813 in contig CP000769_GR.
KEGG	afw:Anae109_3813.
NMPDR	fig|404589.4.peg.3274.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	CKRALKQ.
Family and domain databases
HAMAP	MF_01445. [Tree]
InterPro	IPR009180. Pept_M22_Osialgl. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
ProDom	PD002367. Peptidase_M22. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00329. gcp. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_ANADF

Accession

Primary (citable) accession number: A7HGZ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 11, 2007
Last modified:	November 3, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)