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Protein

Alanine racemase

Gene

Anae109_3487

Organism
Anaeromyxobacter sp. (strain Fw109-5)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Anae109_3487)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei43Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei141SubstrateUniRule annotation1
Active sitei266Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei314Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciASP404589:G1G9J-3602-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Anae109_3487Imported
OrganismiAnaeromyxobacter sp. (strain Fw109-5)Imported
Taxonomic identifieri404589 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
Proteomesi
  • UP000006382 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi404589.Anae109_3487

Structurei

3D structure databases

ProteinModelPortaliA7HG24
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini245 – 373Ala_racemase_CInterPro annotationAdd BLAST129

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OMAiWRGPILL
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

A7HG24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTDPSQWGG RPVWAEIDLD ALAHNVRLLA ARAAPSKLYA VVKANAYGHG
60 70 80 90 100
AIAVGRAALA AGASALAVVC VDEAEELRRG GVDAPILVIG YTPPADAARV
110 120 130 140 150
VALDLRPTVA SADVAEALAV AAKRRGVPVA VHLELETGLN RHGLTPDALV
160 170 180 190 200
ALATRLRAMP ELRVEGLFTH FAAAEEGDQR FTRRQFDVLR DVSARLSWIP
210 220 230 240 250
ERHCAASASL LLDHEMALEV VRAGLSMYGY RPAPWCGTDA DLRPVLSLRA
260 270 280 290 300
RVARVLEVER GATVGYGRTW AAARPSRVAL VMCGYADGYR RSLGNRAHLL
310 320 330 340 350
VRGRRAPVVG RVAMDMCMVD VTAVPEVRAG DVATLLGRDG EERVDADELA
360 370 380 390
SLADTISWEI LAGITARVPR LYLRGGVVES VSTLAERVPL APG
Length:393
Mass (Da):41,909
Last modified:September 11, 2007 - v1
Checksum:i3C5E82913AE41A73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000769 Genomic DNA Translation: ABS27670.1
RefSeqiWP_012098292.1, NC_009675.1

Genome annotation databases

EnsemblBacteriaiABS27670; ABS27670; Anae109_3487
KEGGiafw:Anae109_3487

Similar proteinsi

Entry informationi

Entry nameiA7HG24_ANADF
AccessioniPrimary (citable) accession number: A7HG24
Entry historyiIntegrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: February 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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